41,031 papers found

CONTEXT: These guidelines were prepared on behalf of the European Association of Urology (EAU) to help urologists assess the evidence-based management of chronic pelvic pain (CPP) and to incorporate the recommendations into their clinical practice. OBJECTIVE: To revise guidelines for the diagnosis, therapy, and follow…

BACKGROUND: Studies evaluating the association of economic variables with mortality have produced mixed findings. OBJECTIVE: We sought to evaluate whether economic crises confer increase in mortality. METHODS: We reviewed studies analysing mortality in the general population in periods of economic crisis compared wit…

An estimated 182,640 women and 1,990 men were diagnosed with breast cancer in 2008, and approximately 40,480 women and 450 men died from the disease. Thus, continued mechanistic studies are needed to understand the causes and develop additional therapeutics for this complicated disease. The MCF-7 cell system is one of…

BACKGROUND: The objective of this study was to systematically review the evidence on the effectiveness of laser therapy as an adjunct to non-surgical periodontal treatment in adults with chronic periodontitis. METHODS: A search was conducted for randomized controlled trials comparing the outcome of periodontitis with…

BACKGROUND: Open access is making a noticeable impact on access to information. In 2005, many major research funders, including the Wellcome Trust, National Institutes for Health (NIH), and the Research Councils UK (RCUK), set out their position in a number of statements. Of particular note was the stipulation that aut…

OBJECTIVES: To assess how trial information reported in conference abstracts differs to their subsequent full publication. METHODS: Randomized trials reported at the American Society of Clinical Oncology conference (1992) were identified. CENTRAL and PubMed (December 2002) were searched to identify corresponding full…

AIM: To evaluate the evidence on the formation of a hard tissue barrier after pulp capping in humans. METHODOLOGY: A PubMed and CENTRAL literature search with specific indexing terms and a hand search were made. The authors assessed the level of evidence of each publication as high, moderate or low. Based on this, the…

BACKGROUND: Paracoccidioidomycosis is a fungal infection found in particular geographic localities in Latin America. Treatment can last for up to two years is often associated with complications, including relapse, but people may die without it. OBJECTIVES: To evaluate drugs used for treating paracoccidioidomycosis.…

Atrial fibrillation remains a common and challenging problem following cardiac surgery. The American College of Chest Physicians, through the Health and Science Policy Committee, established a panel to develop a set of clinical practice guidelines for the management or prophylaxis of atrial fibrillation or flutter in p…

Intracranial involvement by Hodgkin's disease is rare. We report a patient with Hodgkin's disease who had intracranial disease at presentation. We also review the literature pertaining to intracranial Hodgkin's disease. Using the key words "Hodgkin's disease" and "central nervous system (CNS) disease", we searched the…

BACKGROUND: Dance is increasingly recognized as a resource for promoting health and well-being. However, research has historically prioritized structured interventions, leaving creative-based dance, emphasizing participant agency and movement generation, comparatively underexplored. This narrative review addresses the…

INTRODUCTION: Empowerment is a central concept in public health used to reduce social inequalities in health. However, its multiple conceptualizations reflect divergent theoretical perspectives, raising epistemological tensions and practical challenges. AIM: This critical literature review aims to analyze the main the…

Knee osteoarthritis (OA) is a chronic, multifactorial joint disorder involving cartilage degeneration, subchondral bone changes, synovial inflammation, and neuromuscular dysfunction. Exercise is first-line therapy, yet heterogeneity in modalities, dosing, and delivery limits practical guidance. A narrative review was c…

INTRODUCTION: Thoracic and lumbar vertebral fractures are rare causes of hemothorax, and data on the clinical characteristics of patients with massive hemothorax caused by blunt vertebral fractures are limited. METHODS: We conducted a literature search using PubMed, Embase, CENTRAL, Web of Science, and Google Scholar…

BACKGROUND: Ghrelin, a brain-intestinal hormone, is a growth hormone (GH) secretagogue. Because it regulates appetite and is secreted most prominently before meals, it is often described as a "hunger hormone". It consists of 28 amino acids. Given the connection between nutritional status and energy metabolism, it sugge…

Social determinants of health (SDH) account for 50% of the variance in health outcomes and significantly contribute to health disparities. Proven strategies to address SDH in practice require interprofessional collaboration and community partnerships. Health professions students need to understand how to work in an int…

: Postoperative thrombocytopenia is a frequent finding after cardiac surgery, affecting approximately 10-40% of patients. The early decline in platelet count, typically observed within the first 48-72 h, is usually explained by hemodilution, perioperative platelet consumption, and the inflammatory or mechanical impact…

This review synthesizes in silico evidence on the toxicological effects of microplastics (MPs) and nanoplastics (NPs) in zebrafish (). With the increasing prevalence of these pollutants in aquatic ecosystems, evaluating their molecular impacts is essential for risk assessment. We systematically mined toxicogenomic stud…

Chronic wounds are a growing healthcare challenge, with infections being major complications that delay healing. Biofilms are structured microbial communities encased in extracellular polymeric substances. Biofilms confer antimicrobial resistance, promote inflammation, and protect pathogens from host defenses. These me…

Cranial neuropathy is a commonly encountered condition with various underlying etiologies. While carotid artery dissection (CAD) is a well-recognized cause of ischemic stroke, CAD-related cranial neuropathy is rare and poorly characterized. We have conducted a comprehensive review of the published literature to better…