96,749 papers found

In recent years there has been a marked increase in the number of reported cases of vaginal intraepithelial neoplasia (VAIN) after hysterectomy. Until about 10 years ago radiation or surgery had been the therapeutic modality mostly used for this disease. More recently, topical drugs, such as bleomycin and 5-fluorouraci…

A study of the mortality due to leukaemias in Spain between 1951 and 1983 was performed. A clearly increasing trend was appreciated, with progressive higher affectation of males in the last four years, the mortality rates being constantly higher for this sex. When cytological types of the leukaemias, sex, and the diffe…

In 1984, four climatic sequences combined to produce what may be a major anoxic catastrophe in the northern Chesapeake Bay, sufficient to severely threaten the major benthic species. These sequences are (i) the highest late-winter streamflow on record from the Susquehanna River watershed; (ii) streamflows from the Susq…

This descriptive epidemiologic study of diabetes mellitus among Indians in northwestern Ontario and northeastern Manitoba provided estimates of the prevalence of diagnosed cases: 28/1000 overall, 46/1000 for those aged 15 to 64 years and 96/1000 for those aged 65 years and over. Diabetes was more prevalent among women…

Background Drug abuse has been on the increase over the last few years, contributing to the healthcare cost. An understanding of the overall impact of drug abuse hospitalizations is essential in combatting the drug abuse epidemic. Objective To evaluate inpatient outcomes of total charges and length of stay for pat…

AIM: The purpose of this retrospective study was to analyze the patency and complications of Gore-Tex grafts used in hemodialysis (HD) access. METHODS: In the last 16 years, 1649 surgical procedures were performed on 655 patients to ensure and maintain permanent HD access. The study group consisted of 64 HD patients o…

Neural damage leads to a transient or persistent alteration, depending on the severity or type of injury sustained. During the last decade, many investigators reported on paresthesia related to dental implants. In this case report, the patient had presented repeatedly with swelling and suppuration, showing typical sign…

PURPOSE: The aim of this study was to review our experience with sigmoid volvulus and to compare the various surgical procedures performed for treatment of sigmoid volvulus. METHODS: A retrospective study of 111 patients with sigmoid volvulus treated at University Hospital in northern India during last six years was p…

PURPOSE: We present our management algorithm for patients with anterior urethral valves seen in the last 2 decades with and without the benefit of prenatal sonography. MATERIALS AND METHODS: A case series design was used to study 17 cases of anterior urethral valves. Five patients presented with prenatal hydronephrosi…

To evaluate the relationship between use of oral contraceptives and risk of invasive cervical cancer, a case-control study involving 479 patients and 789 population controls was undertaken in 5 geographic regions of the US. Initially, the relationship was obscured by confounding variables, particularly the interval sin…

Natural killer (NK) cell therapy began decades ago with administration of small doses of minimally-characterized cells known as cytokine-induced or lymphokine-activated killer cells (CIK or LAK, respectively). Methods and conditions that enabled the broad adoption of T cell therapies have often been less effective for…

Central Sahel is affected by a reinforcement of rainfall since the beginning of 1990s. This increase in rainfall is affected by high inter-annual variability and is characterized by extreme rain events causing floods of unprecedented magnitude. However, few studies have been carried out on these extreme events. Moreove…

The management of anti-neutrophil cytoplasmic antibody-associated vasculitis has substantially improved in the last decade. For the induction of remission, rituximab is increasingly used in place of cyclophosphamide, particularly for patients with proteinase 3 (PR3)-associated vasculitis or relapsing disease, and those…

PURPOSE OF REVIEW: Surgical training has dramatically changed over the last decade. It has become not only the way to prepare surgeons for their everyday work, but also a way to certify their skills thus increasing patient safety. This article reviews advances in the use of machine learning and artificial intelligence…

Induced pluripotent stem cells (iPSCs) represent today an invaluable tool to create disease cell models for modeling and drug screening. Several lines of iPSCs have been generated in the last 7 years that changed the paradigm for studying diseases and the discovery of new drugs to treat them. In this article we focus o…

Polycyclic aromatic hydrocarbons (PAHs) are a family of contaminants that consist of two or more aromatic rings fused together. Soils contaminated with PAHs pose significant risk to human and ecological health. Over the last 50 years, significant research has been directed towards the cleanup of PAH-contaminated soils…

INTRODUCTION AND OBJECTIVES: Genomic medicine investigates groups of genetic markers that determine susceptibility for complex diseases. The aim of this review was to introduce genomics to the clinical otorhinolaryngologist. Technological advances in genotyping and sequencing that have facilitated genome-wide associati…

INTRODUCTION: The key to heal primary hyperparathyroidism is to find the hyper functioning parathyroid gland(s). Promoting this the perioperative isotope guided localization technique is worldwide used in the last years. AIM: Authors use this method since February, 2000. They present their experiences. METHODS: At 12…

PURPOSE: During the last 10 years there has been controversy in the approach to severe hypospadias. Many pediatric urologists have elected to perform a 2-staged procedure to minimize complication rates and improve cosmesis. We continued to perform a single staged repair using the Hodgson XX or Koyanagi technique for ev…

Over the last 6 years there has been a decline in the incidence of measles in Cape Town. However, during August 1992 an outbreak occurred, with cases reported at many schools in children presumably immunised. The objectives of this study were to characterise the epidemic in Cape Town and to determine possible reasons f…