1,557,824 papers found

No effect of penicillamine upon intelligence was found in boys with Duchenne muscular dystrophy when compared to placebo administered in a double-blind fashion. All children, however, showed a significant progressive decline in intelligence quotient. An analysis of mental age showed no change over a 24-month period, su…

A double-blind controlled trial was conducted of emepronium bromide against placebo in elderly mentally ill patients in hospital with urinary incontinence. No significant difference was found between 200 mg emepronium bromide 3-times daily and placebo in treating day-time or nocturnal urinary incontinence for patients…

A double-blind study of oral metoprolol and propranolol in nine patients with chronic bronchitis (Medical Research Council definition) showed no appreciable deterioration in lung function or significant differences between the two drugs.

The purpose of this double blind study was to evaluate the efficiency and safety of a new analgesic drug meptazinol, compared to pentazocine and placebo, in patients suffering from postoperative pain. Subjective and objective parameters were controlled. It appeared clearly that meptazinol had a potent analgesic effect…

A double blind study is described in which 17 patients with intractable pruritus vulvae were treated by multiple intradermal injections of absolute alcohol. In each patient half the vulva was treated with alcohol whilst the other half was injected with water. Treatment with alcohol was significantly better than treatme…

A randomized prospective clinical trial has been performed to determine the effect of temporary immobilization of the shoulder on wound drainage following radical mastectomy. In 64 patients admitted to the trial the mean volume of drainage was reduced by 40 per cent in those who had shoulder movement restricted for the…

In a double-blind crossover trial on forty chronic bronchitics Phyllocontin Continus tablets were shown to produce a greater improvement in objective lung function tests than Ventolin tablets. A combination of Ventolin tablets and Phyllocontin tablets were found to produce a greater effect than either drug alone. Chang…

Fourteen patients with acute severe asthma necessitating hospital admission were all treated with a standard therapeutic regimen, and in addition received either bromhexine or placebo (initially intravenously and subsequently orally) double-blind. We were unable to show any significant improvement in the rate of recove…

Of 40 patients who underwent transurethral prostatectomy without receiving antimicrobial chemoprophylaxis 13 had significant bacteriuria at some time in the postoperative course. Of 47 patients given nitrofurantoin none of the 42 for whom culture results were available had bacteriuria. This difference between the 2 gro…

Carticaine and prilocaine (without adrenaline) in epidural anaesthesia were compared in a double blind study. Carticaine and prilocaine were used in 2 % concentration without adrenaline. The latency time was not significantly different, but carticaine was a shorter acting local anaesthetic. The motor block in both seri…

In a double-blind crossover trial of three days duration on each drug, trimebutine in a dose of 200 mg three times daily was significantly more effective than placebo in relieving the symptoms of mild to moderate degrees of spastic colon (p less than 0.001). The only side-effect necessitating discontinuation of treatme…

A double-blind comparison of meglumine iodamide and Renografin 60 (52% meglumine diatrizoate and 8% sodium diatrizoate) for bolus excretory urography was performed. Doses of 0.8 cc/kg. to a maximum of 55 cc were administered to fifty patients, twenty-five receiving each drug.There is a suggestion that iodamide may be s…

The results of a double-blind controlled study of the modified Makari skin test for the detection of cancer are described. The test identified malignant disease in 95% of 37 patients with primary cancer and in 74% of 81 with recurrent cancer after the exclusion of "anergic" patients. The study suggests that the test wi…

The authors tested the effects of 2-Br-ergocriptine (bromocriptine, CB-154), a drug which exerts a mixed agonist-antagonist activity on the dopaminergic receptors, in 12 patients with Huntington Chorea in a double-blind crossover trial. This treatment significantly reduced the abnormal involuntary movements and the dis…

The clinical effect of disodium cromoglycate was compared with placebo in patients with perennial allergic rhinitis. The results of a double-blind cross-over trial in 17 patients suggest that insufflation with 10 mg disodium cromoglycate four times a day has no better effect than placebo. No significant differences bet…