42,210 papers found

INTRODUCTION: Art therapy (AT) is a non-pharmacological complementary intervention that integrates biological, psychological, and cultural dimensions of healing through creative expression. This narrative review aims to synthesize the historical evolution, theoretical foundations, and clinical applications of AT, propo…

BACKGROUND: Research and academic publications are crucial for Indian physicians' professional growth, evidence generation, and academic advancement. It often contributes to the "publish or perish" culture. This study aims to assess Indian physicians' perceptions and self-appraisal on academic publications, for those p…

There has been an increase in the number of older populations globally leading to a higher likelihood of multi-morbidities necessitating the use of multiple medications. This often poses the risk of potentially inappropriate medications (PIMs) and polypharmacy among older adults, but their data in the Nepalese context…

INTRODUCTION: Cognitive impairment is a prevalent but underrecognized comorbidity in Heart Failure (HF). This review aimed to synthesize recent evidence on the heart-brain axis, focusing on cerebral perfusion, brain structural changes, and their impact on cognition. METHODS: We systematically searched PubMed, Scopus,…

INTRODUCTION: Medulloblastoma is the predominant malignant neuroepithelial tumor in the central nervous system among children and is recognized as one of the most aggressive tumor types. Despite advances in multimodal therapy, prognosis for certain subgroups remains poor, and survivors often face severe long-term seque…

Empty sella (ES) involves herniation of the pituitary fossa, leading to pituitary flattening. While typically associated with central hypothyroidism, its co-occurrence with hyperthyroidism is rarely reported and often overlooked. We report a rare case of hyperthyroidism in a patient with ES. The patient was diagnosed w…

INTRODUCTION: Prostate cancer is typically diagnosed following prostate biopsy. In low-risk and selected favourable intermediate-risk disease, active surveillance is the treatment strategy of choice. In these men, a confirmatory biopsy performed. We report on the rates of risk upgrading at biopsy confirmatory that may…

BACKGROUND: Ameloblastic carcinoma (AC) is a rare malignant odontogenic tumor with limited knowledge surrounding its pathogenesis, molecular pathways, clinical behavior, treatment, and prognosis. This 40-year literature scoping review aims to enhance the comprehension of this complex condition, looking closely at how A…

INTRODUCTION: Extracorporeal membrane oxygenation (ECMO) remains a mainstay for refractory respiratory failure in select pediatric patients. Clinical practice surrounding its use continues to evolve, reflecting advances in technology, management strategies, and patient selection. Ongoing research and innovation are act…

Multiple sclerosis (MS) is an autoimmune disease that involves the central nervous system. MS is prevalent among young adults and progressively destroys axons and myelin. Individuals with MS often experience complications, such as lower urinary tract dysfunction, urinary tract infections (UTIs) and sexual dysfunction.…

BACKGROUND AND OBJECTIVES: Local and systemic inflammation is common after surgery and is associated with morbidity and mortality. Inflammatory cytokines have been implicated in cancer metastasis following cancer surgery. The present study aimed to analyze inflammatory cytokines levels after surgery under combined epid…

INTRODUCTION: Chronic cough is a persistent condition that significantly affects patients' quality of life and poses diagnostic and therapeutic challenges. Traditional anatomical diagnostic approaches often fail to address the underlying mechanisms, leading to suboptimal treatment outcomes. AREA COVERED: This review a…

OBJECTIVE: To summarize significant research contributions published in 2023 in the field of clinical decision support (CDS) systems and to select the best papers for the Decision Support section of the International Medical Informatics Association (IMIA) Yearbook 2024. METHODS: We refreshed a previous search query fo…

OBJECTIVES: To compare the accuracy rates of the detection and staging of oesophago and gastric carcinomas between PET/MRI and PET/CT. METHODS: An extensive librarian-led literature search of PubMed, Embase, Web of Science, the Cochrane Central Library, and CNKI was performed and a meta-analysis was done. RESULTS: Si…

The social determinants of tuberculosis (TB) are well established. However, evidence indicates that genetic variants may also significantly influence an individual's susceptibility to or resistance to TB. The risk of TB is connected to polymorphisms in genes related to immunity and inflammation. While there is a growin…

This systematic review and meta-analysis examined the interplay among neural, physiological, and behavioral interpersonal synchrony. We included studies written in English, comprising human dyads, and reporting data that could be translated to correlation estimates between at least two modalities of synchrony, sourced…

Metformin is recommended as the first-line agent for the management of type 2 diabetes following lifestyle and dietary changes. The long-term use of metformin has been associated with vitamin B12 deficiency. The aim of this review is to investigate the effect of metformin on vitamin B12 levels and identify any risk fac…

OBJECTIVE: To review the current literature describing corneal changes observed with orthokeratology (ortho-k) use and to formulate preliminary recommendations for these patients seeking corneal refractive surgery. METHODS: The literature search was conducted through the PubMed, Scopus, and Ovid databases through June…

BACKGROUND: Pyridostigmine is hypothesized to improve neurogenic orthostatic hypotension (nOH) symptoms without causing or exacerbating supine hypertension. The objective of this review was to evaluate the safety and efficacy of pyridostigmine for management of nOH. METHODS: A literature search of PubMed, Embase, and…

In 15-30% of couples with infertility, no abnormalities are found after the initial diagnostic work-up. The aim of this study was to investigate the prevalence of endometriosis in patients with unexplained infertility undergoing diagnostic laparoscopy in the current era of improved imaging and assisted reproductive tec…