44,629 papers found

BACKGROUND: Iron overload syndromes encompass a wide range of hereditary and acquired conditions. Major developments in the field of genetics and the discovery of hepcidin as a central regulator of iron homeostasis have greatly increased our understanding of the pathophysiology of iron overload syndromes. AIM: To revi…

To review the current status of sacral neuromodulation (SNM) in the treatment of intractable overactive bladder symptoms, the PubMed English-language literature was used to address efficacy, technical issues, alternative techniques, the mechanism of action, adverse events, the cost-effectiveness, and current considerat…

PURPOSE: To identify worksite practices that show promise for promoting employee weight loss. DATA SOURCE: The following electronic databases were searched from January 1, 1966, through December 31, 2005: CARL Uncover (via Ingenta), CDP, CINAHL, Cochrane Central Register of Controlled Trials, Cochrane Library, CRISP,…

Drug interactions are commonly seen in the treatment of cancer patients. Psychotropics are often indicated for these patients since they may also suffer from pre-existing psychological disorders or experience insomnia and anxiety associated with cancer therapy. Thus, the risk of anticancer drug (ACD)-psychotropic drug-…

DATA SOURCES: The National Library of Medicine (Washington DC; to access Medline-PubMed) and the Cochrane Central Register of Controlled Trials were searched for articles dated from 1965 up to November 2007. STUDY SELECTION: Two independent reviewers assessed studies for inclusion, aiming to identify appropriate rando…

CONTEXT: These guidelines were prepared on behalf of the European Association of Urology (EAU) to help urologists assess the evidence-based management of chronic pelvic pain (CPP) and to incorporate the recommendations into their clinical practice. OBJECTIVE: To revise guidelines for the diagnosis, therapy, and follow…

An estimated 182,640 women and 1,990 men were diagnosed with breast cancer in 2008, and approximately 40,480 women and 450 men died from the disease. Thus, continued mechanistic studies are needed to understand the causes and develop additional therapeutics for this complicated disease. The MCF-7 cell system is one of…

BACKGROUND: The objective of this study was to systematically review the evidence on the effectiveness of laser therapy as an adjunct to non-surgical periodontal treatment in adults with chronic periodontitis. METHODS: A search was conducted for randomized controlled trials comparing the outcome of periodontitis with…

BACKGROUND: Open access is making a noticeable impact on access to information. In 2005, many major research funders, including the Wellcome Trust, National Institutes for Health (NIH), and the Research Councils UK (RCUK), set out their position in a number of statements. Of particular note was the stipulation that aut…

OBJECTIVES: To assess how trial information reported in conference abstracts differs to their subsequent full publication. METHODS: Randomized trials reported at the American Society of Clinical Oncology conference (1992) were identified. CENTRAL and PubMed (December 2002) were searched to identify corresponding full…

AIM: To evaluate the evidence on the formation of a hard tissue barrier after pulp capping in humans. METHODOLOGY: A PubMed and CENTRAL literature search with specific indexing terms and a hand search were made. The authors assessed the level of evidence of each publication as high, moderate or low. Based on this, the…

BACKGROUND: Paracoccidioidomycosis is a fungal infection found in particular geographic localities in Latin America. Treatment can last for up to two years is often associated with complications, including relapse, but people may die without it. OBJECTIVES: To evaluate drugs used for treating paracoccidioidomycosis.…

Atrial fibrillation remains a common and challenging problem following cardiac surgery. The American College of Chest Physicians, through the Health and Science Policy Committee, established a panel to develop a set of clinical practice guidelines for the management or prophylaxis of atrial fibrillation or flutter in p…

Intracranial involvement by Hodgkin's disease is rare. We report a patient with Hodgkin's disease who had intracranial disease at presentation. We also review the literature pertaining to intracranial Hodgkin's disease. Using the key words "Hodgkin's disease" and "central nervous system (CNS) disease", we searched the…

BACKGROUND: Vestibular and oculomotor dysfunction after concussion may cause persistent dizziness, imbalance, visual motion sensitivity, and functional limitation. Virtual reality (VR) and technologies are used for assessment and rehabilitation, but applications, devices, and outcomes remain heterogeneous. This review…

This systematic review and single-arm meta-analysis synthesized evidence on the safety and efficacy of prostatic artery embolization with cyanoacrylate glue for benign prostatic hyperplasia. PubMed, Embase, and Cochrane Central Register of Controlled Trials were systematically searched, and eight studies comprising 723…

OBJECTIVE: To generate comparative evidence on outcomes of hysteroscopic (HS) vs vacuum aspiration (VA) for retained products of conception (RPOC). METHODOLOGY: We included all study designs comparing HS with VA for RPOC and available on PubMed, CENTRAL, Scopus, Embase, and Web of Science up to 15January 2025. Surgica…

: The aims of this study were to explore the genetic variants identified by Next-Generation Sequencing (NGS) in patients presenting syndromic/non-syndromic cleft palate (CP) associated with tooth agenesis (TA) and to describe the observed phenotype-genotype correlations.: A systematic review exploring PubMed, Scopus an…

BACKGROUND: Orbital reconstruction materials and implants are central to restoring orbital anatomy and function after trauma and related defects. Although research has expanded steadily, the global landscape, thematic evolution, and intellectual structure of this field have not been systematically characterized. This s…

BACKGROUND: Tourette syndrome (TS) has traditionally been conceptualized as a movement disorder characterized by involuntary motor and vocal tics. However, growing evidence suggests that tic generation involves complex interactions between neural, physiological, and psychological processes, particularly the role of pre…