97,291 papers found

Among 257 patients with clinical diagnosis of Down's syndrome, 56.4% of male gender, in whom cytogenetic studies were performed, 14 (5.4%) had normal karyotypes and 243 (94.6%) had 21 trisomy. Of these last, 225 (92.6%) had free 21 trisomy, 10 (4.1%) showed mosaics, 8 (3.3%) had translocations. Average maternal age of…

Hycanthone at a dose of 2.5 mg kg body weight was given in 1973 and 1974 to persons found by a sedimentation concentration technique to be excreting Schistosoma mansoni eggs. In a further two campaigns oxamniquine was used (15 mg/kg body weight). The last treatment was given after the 1976 survey and stools of children…

PURPOSE: To evaluate the role of intravitreal anti-VEGF with moxifloxacin in intraocular tubercular granuloma. METHOD: This retrospective interventional study was conducted at a referral uveitis clinic between January 2022 and 2025. All patients who had received intravitreal anti-VEGF with moxifloxacin along with syst…

BACKGROUND: Endovascular embolization represents the method of choice for the treatment of carotid-cavernous fistulas (CCFs). METHODS: We report our experience using the endovascular technique in 24 patients harboring 25 CCFs treated between October 1994 and April 2010, with an emphasis on the role of detachable ballo…

OBJECTIVE: The aim of this study was to evaluate, in runners participating in the 2019 Rome Marathon, the interaction between resilience and coping and how they are influenced by sex, age, body weight, height, number of weekly training sessions, and the time of the last marathon. DESIGN: Cross-sectional study. SETTIN…

OBJECTIVE: To identify factors associated with the neurological outcome of HSVE in children. MATERIALS AND METHODS: In this retrospective multicentric observational study, clinical, paraclinical data at onset and neurological outcomes at last follow-up of children (&#x2265;28 days and <18 years old) with HSVE, were st…

IMPORTANCE: Rhinoplasty is a common operation in which shape and function are intimately related, whether the procedure is cosmetic, functional, or combined in nature. There is currently no properly developed and validated patient-reported outcome measure (PROM) to evaluate both functional and cosmetic components of rh…

OBJECTIVE: To explore the effectiveness of minimally invasive transforaminal lumbar interbody fusion (MI-TLIF) for degenerative lumbar scoliosis stenosis by expandable tubular retractor. METHODS: Between April 2009 and October 2010, 39 patients with degenerative lumbar scoliosis stenosis were treated. Of 39 patients,…

&#x2003;The present systematic review aimed to investigate the influence of high physical demand on the increase in muscle and ligament injuries in professional soccer athletes.&#x2003;We analyzed scientific publications to determine the incidences of the main injuries, their causes and mechanisms, and their associatio…

Enhanced signaling through RAS and the mitogen-associated protein kinase (MAPK) cascade underlies the RASopathies, a family of clinically related disorders affecting development and growth. In RASopathies, increased RAS-MAPK signaling can result from the upregulated activity of various RAS GTPases, enhanced function of…

BACKGROUND: In the last few years, quality of life (QoL) has become an outcome measure in patients with pituitary diseases. OBJECTIVE: To describe the available data on QoL impairment evaluated with questionnaires in patients with pituitary diseases. DESIGN: Critical review of the pertinent literature and pragmatic d…

Endoscopic disc surgery (EDS) for lumbar spine disc herniation is a well-known but developing field, which is increasingly spreading in the last few years. Rate of recurrence/residual, complications, and outcomes, in comparison with standard microdiscectomy (MD), is still debated and need further data. We performed an…

Peptides have unique properties that make them useful drug candidates for diverse indications, including allergy, infectious disease and cancer. Some peptides are intrinsically bioactive, while others can be used to induce precise immune responses by defining a minimal immunogenic region. The limitations of peptides, s…

The objective of this study was to analyze in detail the time trend in prostate cancer mortality in the population of Tyrol, Austria. In Tyrol, prostate-specific antigen tests were introduced in 1988-1989 and, since 1993, have been offered to all men aged 45-74 years free of charge. More than three quarters of all men…

OBJECTIVE: To determine whether recent immigration to Canada constitutes a risk factor for excessive gestational weight gain (GWG) in our patient population. METHODS: We performed a retrospective chart review of all deliveries performed by five obstetricians at the McGill University Health Centre in Montreal between 1…

A major factor attributed to the problem and consequences of underage alcohol use is binge drinking. The objective of this study was to examine binge drinking and other alcohol-related problem behaviour among high-risk male and female adolescents who were from alternative schools and programs because of learning and/or…

Neonatal surgical mortality has steadily fallen over the last five decades. Improved survival does not appear to be related to the introduction of new operative procedures. Most of the basic procedures were developed by 1960. Eight developments appear to be responsible: (1) The growth of pediatric surgery resulted in w…

Fundoplication and gastrostomy are among the more common operative procedures performed in infants and children. This article reviews the techniques, results, and complications of the surgical treatment of gastroesophageal reflux in 389 consecutive pediatric patients over the last 5 years. Chronic unremitting vomiting,…

Background Drug abuse has been on the increase over the last few years, contributing to the healthcare cost. An understanding of the overall impact of drug abuse hospitalizations is essential in combatting the drug abuse epidemic. Objective To evaluate inpatient outcomes of total charges&#xa0;and length of stay for pat…

AIM: The purpose of this retrospective study was to analyze the patency and complications of Gore-Tex grafts used in hemodialysis (HD) access. METHODS: In the last 16 years, 1649 surgical procedures were performed on 655 patients to ensure and maintain permanent HD access. The study group consisted of 64 HD patients o…