97,828 papers found

Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s, their popularity has grown exponentially. Moreover, more than 50% of all contributions on the topic have been published in the last 5 years. In…

Quercetin is a kind of typical flavonoid, mainly found in various vegetables, fruits and Chinese herbs that are consumed daily, with the functions of anti-oxidation, anti-tumor, prevention and treatment of cardiovascular and cerebrovascular diseases. Quercetin is a natural compound with defined anti-tumor activity. Due…

We highlight the development of nanocontainer-based active materials started in 2006 at the Max Planck Institute of Colloids and Interfaces under the supervision of Prof. Helmuth Möhwald. The active materials encapsulated in the nanocontainers with controlled shell permeability have been first applied for self-hea…

Over the last 5 years, new oral anticoagulant options, including dabigatran, rivaroxaban and apixaban, have become available. Prior to this, vitamin K antagonists were the sole oral anticoagulants, which have been in use for more than 60 years. These novel agents have been studied in a variety of patient populations, i…

Laparoscopic pyloromyotomy was first reported 20 years ago. This technique uses a small umbilical incision and 2 small upper abdominal incisions. During the last 5 years, this approach has become the preferred technique for many pediatric surgeons in the infant who needs a pyloromyotomy. Recently, with the advent of si…

A 36-year-old man was admitted to our hospital due to dyspnea and pneumonia. He had undergone left classical Blalock-Taussig shunt at 5 years old and right modified Blalock-Taussig shunt at 16 years old, because he was judged as no indication for any radical operation. Since the last surgery, he had stopped visiting ho…

Magnetic recording technology has come a long way, since the introduction of the first hard disk drives (HDD) in 1956. The areal density has grown by a factor of 200 million times and the HDD has stayed as a main candidate for mass storage of information. In order to maintain its lead over other competing technologies,…

The aim of this study was to know the incidence of tick-borne rickettsial disease in a Mediterranean area. The incidence in 5 years for 100,000 inhabitants was 1.7 for tick-borne-lymphadenopathy (TIBOLA) and 0.4 for Mediterranean spotted fever (MSF). MSH incidence during the last few years has been lower than expected;…

The ideal management of colloid cysts is controversial. Treatment options include shunting procedures, stereotactic cyst aspiration, open craniotomy for microsurgical removal, and endoscopic removal. Although recent literature would suggest endoscopic removal is a reasonable approach, issues of safety and efficacy have…

This report traces the evolution of surveillance programmes for influenza in the United Kingdom and countries of western Europe since the World Health Organisation (WHO) resolution to establish an international influenza reference centre in 1947. The introduction of clinical surveillance schemes in the late 1960s and t…

BACKGROUND: The underlying pathology of recurrent IIIrd (and VIth) Nerve palsy are often unknown. Long-term observation sometimes reveal surprising causes. PATIENT: At the first presentation in the clinic the patient was 5 years old and suffered from the second episode of the palsy (which regressed quickly). Two recur…

PURPOSE: We assessed the urological components of ischiopagus twins and outcomes of surgical correction. MATERIALS AND METHODS: We performed a longitudinal study of 3 pairs of twins who presented to a single institution for repair and analyzed the outcomes of certain aspects of repair. RESULTS: Three pairs of twins j…

Hypospadias is a common congenital anomaly in male newborns. The incidence is about one in 300 live male births. In the U.S., about 6000 boys with hypospadias are born each year. For this study, we collected 117 recent (with the last 5 years) cases (88 fresh and 29 referred) who received an operation in our department.…

We present 4 cases of adenoid cystic carcinoma from different locations (parotid, submaxillary, larynx and auditory duct) and we underline the supraglottic origin of one of them. We point out the good clinical behaviour of this carcinoma, with a long tested survival, more than 5 years, in 2 of our cases. All of them sh…

Presentation of 9 cases of synergistic genitalia and perineum necrosing fascitis treated in our service over the last 5 years. The contents of the disease and its terminology has been reviewed by the light of the existing literature. In our series, patients mean age was 65 years. Three of our 9 patients had diabetes me…

Forty nine asthmatic children were studied to clarify the relationship between the respiratory threshold of acetylcholine (RT-Ach) and the prognosis for asthma. In those patients who had asthmatic attacks fewer than 60 days in the last year, there was a statistically significant relationship between RT-Ach and the numb…

Nine cases of multiple-shot suicides (suicides involving more than two gunshot wounds) examined in the last 6 years at the Office of the Chief Medical Examiner. State of Maryland, are reported. All victims, with the exception of one, were white: three were women and six were men, with ages ranging from 22 to 81 years.…

True polar wander, the shifting of the entire mantle relative to the earth's spin axis, has been reanalyzed. Over the last 200 million years, true polar wander has been fast (approximately 5 centimeters per year) most of the time, except for a remarkable standstill from 170 to 110 million years ago. This standstill cor…

For the last 7 years we administered therapeutic doses of radiation therapy as adjuvant treatment after radical prostatectomy in 45 patients at high risk for recurrence, that is patients with pathological stage C (seminal vesicle invasion) or stage D1a (microscopic involvement of the resected pelvic lymph nodes) diseas…

In the period between 1960--1978 36 children dead with acute lymphoblastic leukaemia (ALL) were studied. Nine cases were found to be in pathological remission, i.e., without any leukaemia infiltrations (7 of these were seen in the last 5 years). The remaining 27 could be divided into two groups on the basis of nuclear…