2,589 papers found

BACKGROUND: The goal of this study is to evaluate our long-term experience with the decision of optimal urgent surgical treatment. METHODS: This study is a retrospective analysis and comparison of patients with acute left-sided malignant bowel obstruction and results after staged or single-stage operations. All hospit…

We investigated the MCP-1 -2518 (A/G) single nucleotide polymorphism (SNP) in Slovak cohort of patients with ischemic heart disease (IHD). Our study comprised 270 patients with IHD, out of them 92 with myocardial infarction (MI). We found that the frequencies of the mutant GG genotype in Slovak patients with IHD (10.7%…

B cell activation factor (BAFF), a recently identified member of the tumour necrosis factor (TNF) family, is a key survival factor during B cell maturation and is essential for the development of B cell tolerance. Breakdown of the regulation of BAFF expression results in excessive BAFF production that impairs B cell to…

BACKGROUND: Repair of an inguinal hernia is one of the most common operations performed in general surgery with significant costs to health care and society. Lichtenstein mesh repair has been the most widely performed groin hernia repair. In this study, we wanted to emphasize the effectiveness of local anesthesia in gr…

INTRODUCTION: Management of patients with chronic constipation (CC), irresponsive to medical treatment, is very difficult. There are some surgical approaches reported for the treatment. In this study we aimed to assess the results of different surgical procedures in patients with severe CC who were refractory to intens…

BACKGROUND: Patients with cancer are frequently treated with anticoagulants, including heparin, to prevent or to treat the deep vein thrombosis. It has been indicated that heparin affects the survival of patients with cancer. Also, the apoptotic and antiproliferative effects of heparin on some cancers has been demonstr…

BACKGROUND: New biologic therapies blocking TNF undoubtly constitute a considerable advancement in the management mentioned diseases, but are also associated with higher risk of activation of tuberculosis. METHODS: An assessment of tuberculosis activation rate in the group of patients with rheumatoid arthritis, juveni…

BACKGROUND AND OBJECTIVES: Autoimmune thyroid diseases are frequent in patients with type 1 diabetes mellitus. The aim of our study was to determine the incidence of autoimmune thyroid diseases (AIT) in the different groups of patients with DM (DM type 1--classical form, DM type 1--subtype LADA, DM type 2) and compare…

UNLABELLED: Determination of antibodies against Borrelia burgdorferi has supporting value in the diagnose of Lyme disease. The purpose of this study was to determine the production of antibodies in a defined group of patients. MATERIAL AND METHODS: The study analysed antibodies in the group of 25 patients with erythem…

BACKGROUND: Polytrauma and its consequences present a rising diagnostic and therapeutic problem we face at ICU every day. The goal of this research was to analyze and improve the diagnostic and treatment procedures. PATIENTS AND METHODS: A prospective research carried out at the multidisciplinary Intensive Care Unit d…

BACKGROUND: In neonates, left-sided obstructive heart defects are critical diseases requiring early recognition, initial stabilization, and transfer to Cardiac Center. OBJECTIVES: To assess management of these neonates in primary care hospitals. METHODS: Retrospective analysis of medical records of neonates admitted…

OBJECTIVES: Paper is focused (1) on the comparison of some parameters (body height, body weight, blood pressure, BMI values) in Gypsy and non-Gypsy women from eastern and western Slovakia; (2) on the comparison of biochemical parameters in the Gypsy minority and majority of western Slovakia. BACKGROUND: There is not e…

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is one of the main cases of mortality and morbidity of population worlwide. In spite of enormous efforts there are not pharmacological agents evidently influencing natural course of disease available. Besides looking for new drugs influencing the long term outcom…

AIM: The relationship between ligaments and bone is a complex and heterogeneous junction involving bone, mineralized fibro cartilage, non-mineralized fibro cartilage and ligaments. Mesenchymal stem cells (MSC) can be used in vivo to control inflammation and aid in tissue repair, according to studies. This review focuse…

Olive oil can be contaminated by fungal toxins; therefore, it is necessary to monitor the incidence of mycotoxins in this oil. In the present study, the pooled prevalence of detectable aflatoxin B(AFB) in olive oil was evaluated using systematic review and meta-analysis approach from 1 January 1991 to 31 December 2020…

Treatment of chronic pain is challenging and there is often failure of recovery, with the need to look at different approaches in its management. Central mechanisms may contribute to chronicity (i.e. disturbance in body schema). Laterality judgment is dependent on body schema and can determine affected central mechanis…

BACKGROUND: A miniature spine-mounted robot has recently been introduced to further improve the accuracy of pedicle screw placement in spine surgery. However, the differences in accuracy between the robotic-assisted (RA) technique and the free-hand with fluoroscopy-guided (FH) method for pedicle screw placement are con…

BACKGROUND: The extent of the benefit of erlotinib in the treatment of advanced nonsmall-cell lung cancer (NSCLC) is still controversial when compared with docetaxel. This meta-analysis was performed to compare the efficacy of erlotinib with docetaxel for different patients with advanced NSCLC. MATERIALS AND METHODS:…

To describe the scientific literature about the diagnosis, prevalence, aetiology, natural course and possible treatment modalities of disc displacements within the temporomandibular (TM) joint. PubMed was searched for specific indexing terms. The search yielded 1211 papers. After screening according to title and abstra…

OBJECTIVES: Our goal was to evaluate the quality of life in patients who underwent an elective lumbar stabilization and fusion. MATERIALS AND METHODS: We treated 208 patients (120 females and 88 males) for degenerative lumbar spine conditions. In 165 cases we performed the transforaminal lumbar interbody fusion (TLIF)…