1,557,824 papers found

Buspirone is a novel anxiolytic chemically unrelated to the benzodiazepines. In clinical trials it has been shown to be as effective as diazepam, with fewer side effects. Buspirone is primarily active in dopaminergic pathways. It has the properties of both a dopamine agonist and antagonist. In this paper a model for tr…

Fifty patients with cutaneous leishmaniasis were treated with dapsone (DDS) approximately 2 mg per kilogram body weight per day for 21 days. Forty patients (80%) were declared cured on the basis of clinical and pathologic criteria. Follow-up examination after 6 months revealed no recurrences. No major side effects were…

A prospective, double-blind, controlled trial is reported in which oral diclofenac, a prostaglandin inhibitor, was given for 1 week immediately following the removal of splintage for fracture of the distal end of the radius. The patients who received the prostaglandin inhibitor had less pain, a more rapid recovery of r…

The clinical efficacy of levamisole was compared to that of vaccine in a controlled trial of a combined treatment performed in 311 patients with acute and subacute brucellosis. As compared with vaccine, levamisole appeared effective in the treatment of active forms of brucellosis both during the control of the active p…

In 54 ears lacking the stapedial arch and the long process of the incus, ossiculoplasty was performed with a shaped auto- or homologous incus as columella. In 29 of the ears, the deep, slender part of the columella was coated with a silastic tube in order to prevent adhesions and dislocation. One year after the operati…

A double-blind versus placebo study with benzydamine mouthwash, to demonstrate the histoprotective and antiinflammatory effects on the oral mucosa during intra-arterial chemotherapy of the head and neck, confirmed on a preliminary basis that benzydamine had a beneficial effect.

The side-effect of pruritus was studied in 31 patients receiving epidural fentanyl 100 micrograms in 8 ml normal saline for postoperative analgesia. A control group of 30 patients received pethidine 1,5 mg/kg 4-6-hourly as required. Thirteen per cent of the patients who received epidural fentanyl experienced pruritus.…

A randomized clinical trial of once-weekly antenatal fetal heart rate monitoring in 539 high-risk patients could find no benefit of monitoring in terms of perinatal mortality, morbidity or Apgar score. The previously well-documented association between abnormal antenatal fetal heart rate traces and low Apgar score was…

Until now the therapy of pollinosis with Galphimia glauca was based on individual experience. We performed a randomized, controlled, multicenter, and double-blind clinical trial to verify the effectiveness of the Galphimia glauca D4 therapy of patients with pollinosis. The average time of observation was 51/2 weeks. Ga…

In a comparative study of topical antibiotic solutions, clindamycin phosphate vs. tetracycline hydrochloride for the treatment of mild t moderate inflammatory facial acne, clindamycin phosphate solution proved to be a superior agent in the reduction of papules and pustules. Both preparations had minimal side effects.

Fenoterol as a powdered inhalation was shown to have a longer and stronger bronchodilator effect than the same dose inhaled from a standard metered dose aerosol in a double-blind double-placebo controlled cross-over study in 13 severely asthmatic children. The powder method of administration is free from many of the di…

In a double-blind study in chronic alcoholics melperone (Buronil) was shown to significantly improve muscular and nervous tension, emotional lability, somatization, ability to sleep, anxiety, depression, paranoid ideation and presumed ability to work, but had no effect on alcoholic craving. The results received from th…

A grading system for following the clinical course of acne was devised in which overall severity of acne is evaluated on a zero to eight scale anchored to photographic standards that illustrate grades 0, 2, 4, 6, and 8. Experience with use of this system in large-scale clinical trials has shown it to be useful and reli…

The technique called hysterometry has been used for the quantitative evaluation of effect of naproxen sodium and naproxen on myometrial tension in vivo during dysmenorrhea. It was observed that "uterine tonicity" - the datum arrived at after hysterometric recording - decreased significantly during naproxen medication i…

Twenty-two children suffering from severe perennial rhinitis were treated with intranasal beclomethasone dipropionate (300 microgram/day) and an identical placebo aerosol in a double-blind cross-over trial. The results confirmed the value of beclomethasone dipropionate in improving nasal symptoms and signs due to peren…

In a double-blind study of 100 outpatients receiving an anaesthetic sequence of methohexitone, nitrous oxide and halothane, significant shortening of recovery time was produced by the i.v. administration of doxapram hydrochloride at the end of anaesthesia. Comparable recovery times were obtained following the administr…

Two drug trials in schizoaffective patients are reported. Nineteen "schizomanic" patients were treated for one month, on a double blind basis, with chlorpromazine or lithium and 41 "schizodepressive" patients with amitriptyline, chlorpromazine or both. In the schizodepressive patients there was a trend to a better resp…