1,557,824 papers found

The evidence that, when patients are appropriately selected, convincing benefit can be realized in the earliest of trials, setting the stage for rapid drug approval, is examined.

Forty female patients received a standardised anaesthetic technique with thiopentone sodium and enflurane. Half of the patients received, under double-blind conditions, either physiological saline or glycopyrronium before induction of anaesthesia; 10 minutes after induction of anaesthesia, all patients received vecuron…

Three multi-tufted short-head toothbrushes were compared on 15 test persons, with respect to their efficiency in removing the plaque from margo gingivae and from the interdentium. With a different design of the bristle bed, all three brushes evidenced very little difference in the cleaning effect which, on the basis of…

The results of a comparative study of the action of a new Soviet agent prazosin in arterial hypertension patients have shown that it does not differ in its pharmacokinetic characteristics from its Finnish analogue and is an effective hypotensive agent. A short course of prazosin treatment caused hypotensive effect in 8…

The reduced speech activity of depressed patients is a consistent finding in many systematic studies. However, this and other nonverbal parameters have seldom been investigated in psychopharmacological studies. In this double-blind study, 21 retarded depressed patients were treated with amitriptyline or pirlindol over…

The effect of zinc on acne is unclear. In this study, only patients with an inflammatory acne were included in a double-blind trial using low doses of zinc gluconate (200 mg/day, corresponding to 30 mg zinc metal). We obtained a significantly different result between zinc and placebo groups in the inflammatory score (p…

In Hungary since 1981, 98 immunocompromised children have been treated with intravenous acyclovir for varicella zoster virus infections. They were treated in an open study or a double-blind study. Results of both are discussed briefly. Overall, five of 74 patients with varicella died, whereas all 24 patients with herpe…

Buspirone is a novel anxiolytic chemically unrelated to the benzodiazepines. In clinical trials it has been shown to be as effective as diazepam, with fewer side effects. Buspirone is primarily active in dopaminergic pathways. It has the properties of both a dopamine agonist and antagonist. In this paper a model for tr…

Fifty patients with cutaneous leishmaniasis were treated with dapsone (DDS) approximately 2 mg per kilogram body weight per day for 21 days. Forty patients (80%) were declared cured on the basis of clinical and pathologic criteria. Follow-up examination after 6 months revealed no recurrences. No major side effects were…

A prospective, double-blind, controlled trial is reported in which oral diclofenac, a prostaglandin inhibitor, was given for 1 week immediately following the removal of splintage for fracture of the distal end of the radius. The patients who received the prostaglandin inhibitor had less pain, a more rapid recovery of r…

The clinical efficacy of levamisole was compared to that of vaccine in a controlled trial of a combined treatment performed in 311 patients with acute and subacute brucellosis. As compared with vaccine, levamisole appeared effective in the treatment of active forms of brucellosis both during the control of the active p…

In 54 ears lacking the stapedial arch and the long process of the incus, ossiculoplasty was performed with a shaped auto- or homologous incus as columella. In 29 of the ears, the deep, slender part of the columella was coated with a silastic tube in order to prevent adhesions and dislocation. One year after the operati…

A double-blind versus placebo study with benzydamine mouthwash, to demonstrate the histoprotective and antiinflammatory effects on the oral mucosa during intra-arterial chemotherapy of the head and neck, confirmed on a preliminary basis that benzydamine had a beneficial effect.

The side-effect of pruritus was studied in 31 patients receiving epidural fentanyl 100 micrograms in 8 ml normal saline for postoperative analgesia. A control group of 30 patients received pethidine 1,5 mg/kg 4-6-hourly as required. Thirteen per cent of the patients who received epidural fentanyl experienced pruritus.…

A randomized clinical trial of once-weekly antenatal fetal heart rate monitoring in 539 high-risk patients could find no benefit of monitoring in terms of perinatal mortality, morbidity or Apgar score. The previously well-documented association between abnormal antenatal fetal heart rate traces and low Apgar score was…