386,737 papers found

An examination is made of a meta-analysis by Attewell, Glase and McFadden which concludes that bicycle helmets prevent serious injury, to the brain in particular, and that there is mounting scientific evidence of this. The Australian Transport Safety Bureau (ATSB) initiated and directed the meta-analysis of 16 observat…

(1) Iloprost, a vasodilatory prostacyclin analogue administered by infusion, is indicated for second-line therapy in patients with severe ischaemia of the lower limbs, when surgical revascularisation fails or is contraindicated. (2) In thromboangiitis obliterans the clinical file on iloprost has remained inadequate sin…

Meta-analyses of the relationship between dietary fat and breast cancer risk using different methodologies have reported conflicting results. This investigation compares methodologic aspects of meta-analyses of patient data (MAP) with meta-analyses of data from the literature (MAL), and computes relative risk (RR) esti…

This article highlights factors that may cause bias in individual controlled trials or meta-analysis of zidovudine (AZT) in HIV disease. The overall benefit of AZT and antiretroviral drug combinations in the progression of HIV disease is probably greater than has been or can ever be shown in an ethical controlled trial…

Currently, North American intergroup trials are conducted according to the Intergroup Guidelines, which require that a lead group take responsibility for data management. Intergroup studies conducted in this manner have been very successful in rapidly accruing large numbers of patients to trials addressing significant…

Many randomised controlled trials compare treatments that will produce only moderate differences in outcome, but these differences can be clinically important. However, they are difficult to assess reliably and require a large amount of randomised evidence. This can be achieved through large prospective randomised tria…

We discuss methods for summarizing epidemiologic studies of dose-response. The data from such a study typically appear as a series of dose-specific relative risks, with one category serving as the common reference group. We present methods for estimating the dose-response parameters from single and multiple study repor…

Earlier studies demonstrated that moclobemide has good efficacy as an antidepressant. Its efficacy was comparable to reference antidepressants, both in endogenous and non-endogenous depression. A meta-analysis was performed of recent data from more than 2000 patients who had participated in double-blind trials with moc…

ARTICLE TITLE AND BIBLIOGRAPHIC INFORMATION: Schiegnitz E, Reinicke K, Sagheb K, König J, Al-Nawas B, Grötz KA. Dental implants in patients with head and neck cancer-A systematic review and meta-analysis of the influence of radiotherapy on implant survival. Clinical oral implants research. 2022 Oct;33(10):967…

Amid rising national rates of childhood depression and anxiety,the development and accessibility of therapeutic psychosocial interventions for children have taken on paramount importance. Given the limited bandwidth of the existing clinical mental health services nationally, there is also an imperative to integrate the…

Systematic Review and Meta-Analyses (SRMAs) hold the highest rank in evidence hierarchy; however, their results are vulnerable to selective reporting and publication bias. Nonsignificant/secondary outcomes, such as adverse events or rare complications, are often omitted from the abstract due to word limits or pressure…

OBJECTIVES: To explore the performance of 4 large language model (LLM) chatbots for the analysis of 2 of the most commonly used tools for the advanced analysis of systematic reviews (SRs) and meta-analyses. MATERIALS AND METHODS: We explored the performance of 4 LLM chatbots (ChatGPT, Gemini, DeepSeek, and QWEN) for t…

While the toxicity of microplastics (MPs) and nanoplastics (NPs) has been demonstrated, studies focusing on plastic leachates (PLs) in isolation remain limited. Herein, we developed a multifactor, multieffect, and multilevel meta-analytic model (3M) to systematically evaluate the toxicity of PLs to aquatic animals and…

Clinical trials must be planned and interpreted in the context of current best clinical and scientific evidence, undoubtedly provided by systematic reviews and meta-analyses, especially Cochrane Reviews. While many clinicians feel overwhelmed by this complex data source, few visualElements (e.g., the traffic light syst…