1,566,707 papers found

A new anti-spasticity agent, brolitene, has been assessed in patients with spasticity of spinal or cerebral origin. Twenty-seven patients were entered in a double-blind cross-over trial lasting 6 weeks, using a fixed dose of six tablets (1200 mg brolitene) per day. Clinical assessment failed to show any therapeutic eff…

This paper reports the results of a double blind study in patients with senile dementia to determine if the quality and quantity of sleep could be changed with various amounts of caffeine. Twelve patients with dementia were studied in a nursing home setting. Patients were medication free for a month prior to the study.…

A double-blind, controlled study was performed in which eight investigators treated a total of 180 psoriasis patients with either betamethasone dipropionate cream or fluocinolone acetonide cream for four weeks. Betamethasone dipropionate cream was clearly superior to the control preparation in the degree of improvement…

Oral aspirin challenge was used to detect unrecognized aspirin intolerance in a select group of 50 asthmatic patients who denied aspirin intolerance. A double-blind protocol was used to further study those patients who reacted to initial graded aspirin challenge. In one patient the use of a double-blind protocol led to…

This clinical double-blind study shows that glucagon (2 mg) is a valuable agent for hypotonic duodenography. Pro-Banthine (45 mg) is slightly more effective as a hypotonic agent, but there is no doubt that its use is associated with more side effects and subsequent patient discomfort; contraindications to its use are m…

A clinical trial is being conducted in which single, nightly doses of 10 mg or 25 mg of clomipramine are added to the conventional analgesic therapy of patients with chronic painful conditions of the locomotor system. The initial impression has been obtained that the pain threshold of such patients can be modified by t…

It has been reported that imipramine reduces the titre of rheumatoid factor in schizophrenic patients. Twenty out-patients suffering from classical rheumatoid arthritis and having rheumatoid factor titre equal to, or greater than 1:64, were treated in a double-blind trial with imipramine 75 mg or matching placebo. In t…

13 psychotic patients developing various degrees of postural hypotension during neuroleptic or antidepressant treatment were additionally given either placebo or a mineralocorticoid or a sympathomimetic drug. As shown by Schellong tests during therapy the best effect on postural hypotension was achieved by the mineralo…

1. A clinical trial of the effects of indomethacin (200 mg daily) failed to show any objective evidence of improvement in six patients. 2. The same dose failed to inhibit exercise and antigen challenge induced bronchoconstriction, and this was considered to be evidence against the hypothesis that prostaglandins act as…

A double-blind trial with pyrithioxine (Encephabol) was made witn 22 pairs of visually handicapped subjects who were equal in IQ scores and in chronological age. Although an improvement of abstraction ability was noticed, the over-all results were not in concurrence with the general tendency in relevant literature. A f…

The clinical trials of Di-n-propylacetate (Depakine, Labaz) produced favorable results with 15 patients, whose epilepsies were characterized by exceptional therapy-resistant absences, partly in combination with grand mal (4 patients). After discontinuation of DPA and renewed application of this drug at a later stage th…