Sample size determination for a binary response in a superiority clinical trial using a hybrid classical and Bayesian procedure.
Ciarleglio Maria M, Arendt Christopher D·Trials
BACKGROUND: When designing studies that have a binary outcome as the primary endpoint, the hypothesized proportion of patients in each population experiencing the endpoint of interest (i.e., π,π) plays an important role in sample size and power calculations. Point estimates for πand πare often c…