98,297 papers found

In recent years, antimicrobial peptides (AMPs) have enjoyed a renaissance, as the world is currently facing an emergency in terms of severe infections that evade antibiotics' treatment. This is due to the increasing emergence and spread of resistance mechanisms. Covalent conjugation with polymers is an interesting stra…

We performed a retrospective study on 30 subjects having subclinical depression in the past, involved in a psychotherapeutically process in the last 5 years, which gradually returned with a post-partum depressive episode. The subjects were between 20 and 38 years of age, without psychotic disorders, selected by psychol…

The investigation of the placebo and the nocebo effect and their mechanisms has a rather short history of less than 20 years, especially in gastroenterology, and only the last 5 years have resulted in substantial improvement of understanding. Placebo refers to symptom improvement following a treatment, nocebo to the op…

Nontransplant therapeutic options for acquired and constitutional aplastic anemia have significantly expanded during the last 5 years. In the future, transplant may be required less frequently. That trilineage hematologic responses could be achieved with the single agent eltrombopag in refractory aplastic anemia promot…

The following is a general overview of the management of CNS germinomas. Over the last 35 years, CNS germinomas have become one of the pediatric brain tumors with the best outcomes with a greater than 85% overall survival over 5 years. This is in part due to the fact that germinomas are very responsive to chemotherapy…

In the 1980s, enteral nutrition became increasingly recognised as a safe, effective and cost-efficient method of providing nutrition to patients with a functional gut (Silk, 2003). With this came the development of feeding-specific nasogastric (NG) tubes (Rees et al, 1986) and the formulation of nutritionally complete,…

Informing a cancer patient has been an issue of particular interest to the scientific community over the last 50 years. Since 1989 we have been studying the characters or personality types based on the Kahana and Bibring's approach as part of Consultation-Liaison (C-L) Psychiatry. The question posed was how these chara…

Hereditary angioedema (HAE) is due to inherited deficiency of C1-inhibitor (C1-INH) and causes localized swelling that may be life-threatening when it affects the larynx. Replacement therapy with plasma derived C1-INH has been the principal life saving treatment for more than 20 years in several European countries. Nev…

INTRODUCTION: In recent years, many scientists involved in cancer research have directed their attention to telomerase, an enzymatic complex which is specifically involved in duplicating telomeres, the very ends of linear chromosomes. The discovery that most immortal cell lines in vitro and human tumor cells in vivo ha…

The painting "The Three Generations" is considered one of the highlights in Charley Toorop's works. It essentially represents a self portrait of the artist herself, with John Rädeker's sculpture of her father Jan Toorop, and her son Edgar Fernhout. The completion of this painting took 9 years (1941-1950). However,…

Spontaneous intracranial haemorrhage is one of the cerebrovascular complications in beta-thalassaemia major patients. This is a report of 2 cases of fatal intracranial haemorrhage. Their ages were 12 and 7 years respectively, and they had been receiving regular blood transfusion for the past 3 and 2 years respectively.…

Survival and clinical status in 105 acromegalic patients followed for up to 24 years after surgery is assessed against serum growth hormone (GH) levels and other factors. Primary treatment was at first (90)Yttrium implants or craniotomy, later transsphenoidal operation. GH levels were similar for each method, and the r…

During the last 5 years 33 patients with faecal incontinence due to childbirth were investigated. Ages varied from 23 to 61 and duration of symptoms from 0.3 to 25 years. Anal manometry was performed in all patients and electromyography was performed in 21 cases. Twenty-seven patients underwent delayed sphincter repair…

During the past 5 years the 4-quinolone antibiotics have progressed from relative obscurity to a highly visible and intensely studied class of compounds. The zeal for developing and marketing newer fluoroquinolones closely parallels that of the cephalosporins for the last 10 years. All of these newer agents appear to h…

From 1971 through 1975, 59 children with hypospadias were operated upon at the Department of Paediatric Surgery of the University Children's Hospital Zürich. The external meatus was penile in 52 and scrotal or perineal in 7 cases. Average patient age at the time of definitive repair was 5 1/2 years. Fistulas or wo…

Until 1980, 300 cases of gastric volvulus had been reported in the literature. Of these only 50 had presented in children. The disease is considered rare. We reviewed our experience at Sainte-Justine, in the last 30 years and found 10 cases, all of which diagnosed since 1980. Four patients were under one year of age. T…

During the years 1945-1980 260 testicular tumors were registered in the two western provinces of Austria ( Tyrol and Vorarlberg ). The histological slices of these tumors were revised and classified according to the revised "British Classification" ( Pugh 1976). 91.9% of investigated testicular tumors were of germinal…

In the examined number of patients the ulcerous colitis played only a secondary role concerning the frequency. A decrease in the last five years could be explained by an improved ambulatory care. This clinical picture is, however, important on account of the inclination to recidivations and the acute complications. Of…

The outcomes during the period 1950--1972 were compared for Wilms' tumor patients in Erie County, New York (Buffalo and environs) and in a random selection of 23 counties having much smaller populations. For the Erie cohorts of 1967 to 1972 an 87 per cent 7-year survival rate was found as compared with a 50 per cent su…

Cadaveric dissection has been a foundational principle of medical anatomic education for the last 400 years, yet medical anatomy course hours have been drastically reduced in the last decades. With this course reduction and the availability of other modalities for anatomic instruction, the physician may question the cu…