43,361 papers found

OBJECTIVE: To evaluate the effects of isometric exercise training (IET) on arterial stiffness (AS) and endothelial function (EF) in middle-aged and older adults through a systematic review and meta-analysis. METHODS: We systematically searched PubMed, Cochrane Library, Embase, and Web of Science databases (up to Janua…

BACKGROUND/AIM: Tremor arises from mechanical, reflex, or central oscillatory mechanisms. Transcranial magnetic stimulation (TMS) can transiently perturb ongoing tremor and enables the quantitative assessment of phase resetting, offering circuit-level insight into tremor types. Although numerous studies have applied TM…

BACKGROUND: Over the last decade, remote technological initiatives for obstetric antenatal care have rapidly developed. However, variation in outcome reporting can preclude effective data synthesis. A remedy for this is to develop of a core outcome set (COS). However, prior to this, it is necessary to examine the heter…

Work-related musculoskeletal disorders are occupational conditions that result from the excessive use of the musculoskeletal system, combined with insufficient time for physiological recovery. These disorders remain prevalent in the automotive industry, particularly on assembly lines, and directly impact workers' healt…

BACKGROUND: Dental pulp sustains oral health through dentine formation, sensation, nutrition and defence. Beyond these classical roles, pulpal nerves have emerged as key coordinators of immune responses and tissue repair. While traditionally viewed as limited to sensory and vascular regulation, recent advances reveal t…

PURPOSE: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in older adults, with its prevalence rising globally. This review aims to explore the potential of Efdamrofusp alfa (EA), a novel bispecific decoy receptor fusion protein targeting both VEGF and complement pathways, in treating…

BACKGROUND: The erector spinae plane (ESP) block has gained attention as a regional anesthesia technique for pain management in vertebral surgeries. This umbrella review synthesizes data from systematic reviews (SRs) and meta-analyses to evaluate the effectiveness of the ESP block in reducing postoperative opioid consu…

BACKGROUND AND AIM: Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome caused by pathogenic variants in the NF1 gene. It exhibits highly variable and unpredictable clinical manifestations involving multiple organ systems, with café-au-lait macules and multiple neurofibromas being…

BACKGROUND: Tuberous Sclerosis Complex (TSC) is a multisystemic neurocutaneous disorder caused by pathogenic loss of function variants in the tumour suppressor genes TSC1 and TSC2. The resultant hamartomas confer significant medical risks by disruption of local tissues. Risk of mortality in TSC is known to be elevated,…

The purpose of this study was to determine the effect of painful versus nonpainful exercise on pain, disability, and other patient-reported outcomes in adults with chronic musculoskeletal pain.This study is an intervention systematic review with meta-analysis.Electronic databases (CENTRAL, EMBASE, CINAHL, PubMed, and P…

BACKGROUND: This network meta-analysis aims to evaluate the comparative efficacy of non-pharmacological interventions on Parkinson's disease (PD) with constipation. METHODS: A comprehensive search was conducted in seven major databases (CINAHL, the Cochrane Central Register of Controlled Trials [CENTRAL], Embase, PubM…

PURPOSE: Improving cardiorespiratory fitness (CRF) before and after colorectal cancer surgery may improve postoperative outcomes. This systematic review and meta-analysis evaluated the effects of perioperative exercise therapy (aerobic, resistance, mind-body, flexibility, or mixed exercise (combined aerobic and resista…

OBJECTIVE: This systematic review aims to evaluate the effectiveness of health literacy interventions compared to standard or usual educational practices for knowledge, skills, and attitudes in community health workers. INTRODUCTION: Health literacy plays a crucial role in improving personal and societal health outcom…

PURPOSE: This review aims to clarify the role of ophthalmic steroids in polypoidal choroidal vasculopathy (PCV) treatment. METHODS: A systematic literature search was performed using Scopus, PubMed, MEDLINE, Cochrane, ProQuest, and manual searches. The primary outcome was changes in best-corrected visual acuity. The s…

BACKGROUND: The Shennong Bencao Jing (Shennong's Classic of Materia Medica) records that Panax ginseng C. A. Mey (ginseng) 'lightens the body and prolongs life'. Many investigations have documented that ginseng exerts neuroprotective effects by mitigating the aging of the brain. However, a comprehensive review of the i…

Chronic lymphoid leukemia (CLL) is a common adult leukemia that has been treated with chemoimmunotherapy, which has significant toxicity among patients. Advances in CLL understanding have led to targeted therapies, such as Bruton's tyrosine kinase (BTK) inhibitors. Acalabrutinib is one of the second-generation BTK inhi…

PURPOSE: Additive cast-fabrication has yet to be used as commonly in implant prosthodontics as conventional methods. This review aimed to investigate the accuracy of additive cast-fabrication in implant prosthodontics. STUDY SELECTION: The study protocol was registered in the PROSPERO database (CRD42022374972). Report…

BACKGROUND: The technological advancements of the past few decades in various aspects that are directly or indirectly related to health, along with the emphasis on public health in societal development, have improved the quality of life. However, the occurrence of pandemics and crises underscores how various aspects of…

BACKGROUND: Acute disseminated encephalomyelitis (ADEM) is a neural and immunerelated disorder that occurs when the cerebrospinal system is damaged by extensive swelling. Although manifestation is possible regardless of age, adolescents have a greater probability. The purpose of the present manuscript is to provide rec…

BACKGROUND: Health care-associated infections (HAIs) are a major threat to patient safety and quality care. However, they are avoidable by implementing evidence-based infection prevention and control (IPC) measures. This review evaluated the evidence of the effectiveness of IPC interventions in reducing rates of HAIs i…