1,574,919 papers found

The effects of oral yohimbine (20 mg) or placebo or both drugs on plasma homovanillic acid (HVA) were evaluated in patients with panic disorder and normal controls. Panic disorder patients had similar HVA values at baseline compared with normal controls, and yohimbine failed to produce appreciable changes in HVA in bot…

The Salk Vaccine Field Trial was a randomized, placebo-controlled trial designed to test the efficacy of the Salk killed virus vaccine. Although the trial was not without some problems, both in design and analysis, none was important enough to raise serious questions about the results. Thus, the design of the Field Tri…

We performed a 3-month, double-blind, placebo-controlled trial of 300 mg of gangliosides (Cronassial) in 40 outpatients with amyotrophic lateral sclerosis (ALS). We evaluated drug effect through physical examinations and symptom scales. Though this dosage had no major toxic effect, Cronassial treatment did not signific…

A controlled double-blind investigation was undertaken in which ten patients with painful bone metastases were treated with intravenous lignocaine in a dosage of 5 mg/kg body-weight infused over a period of 30 minutes or the same volume of isotonic saline. None of the patients experienced prolonged pain relief but five…

A double blind study was conducted utilizing the EDL/Biometrics Reading Eye Camera to determine if poor diets and altered reactions could have a detrimental effect on the eye movements of a group of dyslexic individuals. The study found that a poor diet, high in sugar, and a provocative challenge of cane sugar caused m…

Though the Hirschberg test has been used for over a 100 years, several different formulas are still being recommended and used clinically to determine the amount of a given ocular deviation. The purpose of this study was to obtain a double-masked clinical evaluation of the Hirschberg test. Several strabismic patients w…

The authors conducted a 16-week double-blind, crossover study in 11 patients with panic disorder to study the effects of verapamil, a calcium channel blocker commonly used in the treatment of cardiovascular disorders, on the treatment of panic disorder. Their findings suggest that verapamil has modest antianxiety and a…

A study was done on 40 outpatients suffering from major affective disorders (uni- and bipolar). Chlorimipramine or maprotiline was administered alternatively (means = 116.25 and 116.75 mg/day, respectively). The therapeutic effect of both antidepressive drugs is very similar, but maprotiline improves the gastrointestin…

Forty-nine patients were treated with either 3 x 75 MBq 89Sr or saline as placebo. Analysis of results 1 to 3 years after therapy revealed the ineffectiveness of 89Sr to relieve pain from metastases. Unexpectedly, a higher survival rate was found after Sr application (46% vs 4% after 2 years). Covariate analysis underl…

Thirty-five patients with menorrhagia were treated in a double-blind crossover study with naproxen sodium and mefenamic acid after measurement of their blood loss during control menstrual cycles. Treatment with these compounds reduced the excessive bleeding by an average of 46 and 47% respectively. Drugs in the prostag…