1,566,425 papers found

Thirty-five patients with menorrhagia were treated in a double-blind crossover study with naproxen sodium and mefenamic acid after measurement of their blood loss during control menstrual cycles. Treatment with these compounds reduced the excessive bleeding by an average of 46 and 47% respectively. Drugs in the prostag…

Ergot derivatives have been used in the treatment of migraine for more than 50 years. We have compared the efficacy of dihydroergotamine (DHE) nasal spray with that of placebo in patients with classic or common migraine attacks. The study was performed in accordance with a double-blind, crossover design. In this study…

As a treatment for tardive dyskinesia, sodium valproate was tested in a double-blind placebo-controlled parallel group trial, with 6-week base-line observation period followed by 6 weeks of treatment. Sodium valproate was not found to be an effective treatment for either tardive dyskinesia or drug-induced Parkinsonism,…

We report unsatisfactory results of electrothrombosis for the treatment of venous angiomas. After we reviewed a report of successful use of electrothrombosis for treating cirsoid angiomas of the face and scalp and varices of the leg, a clinical trial was begun with 6 patients in whom previous conventional surgery was r…

We compared nebulised beclomethasone dipropionate suspension against placebo in 16 children with moderately severe asthma in double blind crossover fashion. Three children withdrew due to deterioration while on placebo. Of the remaining 13, eight were better on beclomethasone and five on placebo. These trends in favour…

Uncomfortable or moderately painful radiologic diagnostic and therapeutic procedures are being performed increasingly on outpatients. If sedation and analgesia are used, patients cannot drive themselves home or return rapidly to normal activities. This study compares the effect of fentanyl (100 micrograms), diazepam (7…

Given the high drop-out rates frequently noted in drug trials with bulimic subjects, we have attempted to correlate drop-out status with a greater level of psychopathology as measured by a thorough standardized psychological assessment battery (NIMH-DIS, EDI, POMS and SCL-90). Despite a trend toward higher scores on th…

24 patients were included in a double-blind, crossover trial to test the efficacy of doxepin (a tricyclic antidepressant) and mequitazine (a new antihistamine of the phenothiazine group). Compared to placebo treatment, both doxepin and mequitazine significantly improved the various clinical parameters evaluated. When t…

The patient-doctor relationship has two fundamental components. The first is the application of the skill and knowledge of the doctor in the care of the whole patient and family. The second is the right of the individual to have information about his or her illness or treatment, and to be involved in decision making. T…

Eleven asthmatic children less than six years were treated double-blind for eight weeks with fenoterol, theophylline or placebo syrups. Both active drugs significantly decreased the incidence of cough compared to placebo. Nocturnal symptoms and wheezes were also reduced but were not improved to a statistically signific…

Chronic sympathetic nervous system overactivity has been implicated in the pathogenesis of both hypertension and hypercholesterolemia. We conducted a controlled trial to determine the effect of a relaxation technique on blood pressure and serum cholesterol in drug free subjects with normal and slightly elevated values.…

Nine of 10 adults, previously healthy patients who suffered cardiac arrest during or after anesthesia, recovered nearly complete neurological function when given iv phenytoin, 7 mg/kg. Phenytoin was given only after spontaneous heart beat and systolic blood pressure greater than 100 mm Hg had been restored and the diag…

The authors carried out studies on 8 volunteers with normal renal function after a single dose of 5-nitrox of 200 to 250 mg (mean 3 mg/kg of body weight). The dynamics of concentrations in plasma and urine was discovered. On the basis of the obtained experimental data the therapeutic scheme of application was indicated…

Lactose intolerance interferes with the recovery phase in patients with severe diarrhoea. A controlled comparison of a lactose-free soy isolate formula (Isomil) and a standard cow's milk-based formula in 112 infants with severe diarrhoea showed a significant advantage for the lactose-free formula. All the infants were…