376,071 papers found

OBJECTIVE: This network meta-analysis (NMA) of randomized controlled trials (RCTs) evaluates the long-term efficacy and feasibility of treatments for macular edema (ME) secondary to retinal vein occlusion (RVO). Comparisons between different alternatives remain unclear. METHODS: We used a Bayesian framework to perform…

OBJECTIVE: To compare the efficacy and safety of four immunosuppressive therapies, either alone or in combination, for primary membranous nephropathy through a network meta-analysis. METHODS: A literature search was conducted for randomized controlled trials (RCTs) of Cyclophosphamide (CTX), Cyclosporin (CsA), Tacroli…

BACKGROUND: Hypoxic environments significantly impair exercise performance, whilst existing interventions are often limited by adverse effects or insufficient efficacy. OBJECTIVES AND METHODS: This study employed network meta-analysis to screen plant bioactive compounds that effectively enhance exercise performance un…

INTRODUCTION: There are conflicting recommendations surrounding the use of intraoperative wound irrigation (IOWI) to reduce surgical site infections (SSIs) for patients undergoing laparotomy. This study aimed to perform a systematic review and network meta-analysis of randomised clinical trials (RCTs) to elucidate the…

INTRODUCTION: Fibromyalgia is a chronic syndrome characterized by widespread musculoskeletal pain, fatigue, depressive symptoms, and sleep disturbances, with substantial impairment in quality of life. Aerobic exercise is widely recommended as a non-pharmacological management strategy, and evidence supports benefits for…

PURPOSE: Congenital hydrocephalus is commonly treated with endoscopic third ventriculostomy (ETV), ETV with choroid plexus cauterization (ETV + CPC), or ventriculoperitoneal shunting (VPS), yet outcomes vary, and treatment failure is frequent. This study examines treatment failure between procedures…

To estimate the comparative effectiveness of tailored exercise therapies in people with chronic, nonspecific low back pain.Systematic review with network meta-analysis.We searched PubMed, Cochrane Library, Web of Science, and Google Scholar from inception to August 27, 2024.Only randomized controlled trials (RCTs) stud…

BACKGROUND: The role of postoperative antithrombotic therapy in microvascular free flap reconstruction remains controversial, with no consensus on the optimal regimen. METHODS: A systematic review and arm-based Bayesian network meta-analysis was conducted searching PubMed, Scopus, and Google Scholar databases. Aspirin…

This systematic review and meta-analysis aimed to determine whether the morphology and linear dimensions of sella turcica differ by the different skeletal malocclusions. PubMed, Scopus, EMBASE, and Google Scholar were comprehensively searched for the relevant articles published until 21 May 2024 using combinations of t…

BACKGROUND: Parkinson's disease is a progressive neurodegenerative disorder that causes significant motor function limitations, substantially impacting the quality of life of affected individuals and their caregivers. While the currently available pharmacological therapy with levodopa can alleviate symptoms, identifyin…

OBJECTIVE: In this study we conducted a meta-analysis of 13 case-control studies that examined the occurrence of hematopoietic cancers in pesticide related occupations in order to undertake a qualitative and quantitative evaluation of a possible relationship. METHODS: Pubmed databases were searched for case-control st…

BACKGROUND: --Pregnancy-induced hypertension (PIH), defined as either isolated hypertension after the 20th week of gestation or hypertension with proteinuria (preeclampsia), occurs in 5% to 15% of pregnancies and is associated with maternal and neonatal morbidity. Previous clinical trials with small numbers of patients…

Vitiligo, a chronic autoimmune skin disorder characterized by refractory depigmentation, has inconsistent associations with various biomarkers and diseases due to confounding factors. Here, we conduct a comprehensive umbrella review and comparative analysis to evaluate the validity and strength of evidence from observa…

Researcher allegiance (RA) is widely discussed as a risk of bias in psychotherapy outcome research. The relevance attached to RA bias is related to meta-analyses demonstrating an association of RA with treatment effects. However, recent meta-analyses have yielded mixed results. To provide more clarity on the magnitude…

The rapid growth of human genetics creates countless opportunities for studies of disease association. Given the number of potentially identifiable genetic markers and the multitude of clinical outcomes to which these may be linked, the testing and validation of statistical hypotheses in genetic epidemiology is a task…

An overview analysis of seven randomized controlled trials testing the effectiveness of aspirin in the treatment of patients with transient ischemic attacks and minor strokes was performed. A total of 6409 patients from the seven trials was entered in the analysis; 2182 patients received only aspirin; 1598 patients rec…

To quantify the effect of estrogen replacement therapy on breast cancer risk, we combined dose-response slopes of the relative risk of breast cancer against the duration of estrogen use across 16 studies. Using this summary dose-response slope, we calculated the proportional increase in risk of breast cancer for each y…

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and fibromyalgia (FM) are chronic, disabling conditions characterized by persistent fatigue, widespread pain, and psychological comorbidities that severely impair quality of life. Pharmacological options remain limited, and exercise is increasingly…

BACKGROUND: Acupuncture has been widely applied to polycystic ovarian syndrome (PCOS) patients. This network meta-analysis (NMA) aims to compare the effects of different acupuncture methods on PCOS from the aspects of hyperandrogenism, metabolic status, sexual hormone disturbance, and infertility. METHODS: We searched…

BACKGROUND: KRAS is a common driver gene in non-small cell lung cancer (NSCLC). Owing to the absence of universally effective targeted agents and marked heterogeneity, optimal treatment selection for KRAS-mutant NSCLC remains uncertain. This study combined network meta-analysis (NMA) with real-world evidence to inform…