Searching PubMed for “Clinical Trial” and checking full-text availability…
for “Clinical Trial” · Showing 9,381–9,400 · 1735 ms
Stiehl A, Czygan P, Kommerell B, +2 more·Gastroenterology
Abstract not available
Sinclair J C·Pediatrics
The Experimental Design Deck for Clinical Research is a simulation of a problem in experimental design in a card deck format. It is intended to stimulate the development of skills in scientific thinking by allowing the student, in a self-directed fashion, to design a clinical trial to test either a given hypothesis (sp…
Sunshine A, Zighelboim I, Laska E·Journal of clinical pharmacology
In a double-blind controlled study, an oral dose of diphenhydramine hydrochloride (12.5, 25, or 50 mg), methapyrilene fumarate (36, 72, or 144 mg), or placebo was administered to 1295 post-partum patients if they complained of, or anticipated, a sleep problem. Hypnotic activity was assessed clinically by subjective and…
Merchant H W, Gangarosa L P, Glassman A B, +1 more·Oral surgery, oral medicine, and oral pathology
A double-blind study of the effectiveness of betamethasone-17-benzoate in the treatment of recurrent aphothous ulcers (RAU) was concucted. The drug was found to be effective in reducing symptoms and shortening healing time but not in preventing recurrences. Evaluation of the medical histories and laboratory studies sug…
Jones E L, Crumley A F, Cornell R C·Cutis
New methods are now available to help select vehicles for topical corticosteroids. In the development of a new cream vehicle for flurandrenolide, the goal was a cream base with optimal solubility for release of the drug, minimal irritation potential, and no sensitizing preservatives. Vasoconstriction tests make selecti…
Muler H, Blum F·Annales d'oto-laryngologie et de chirurgie cervico faciale : bulletin de la Societe d'oto-laryngologie des hopitaux de Paris
Abstract not available
Zak A F, Ermolova O B, Batuashvili T A, +2 more·Antibiotiki
Blood absorption of tetracycline hydrochloride of various dispersity levels from capsules containing tetracycline alone or in combination with additives, such as magnesium carbonate and calcium salts was studied on humans. It was found that higher dispersity levels of tetracycline hydrochloride powder in capsules was n…
Eisenberg R L, Mani R L, Hedgcock M W·Radiology
In a double-blind study, 28 patients for peripheral angiography received contrast injection both with and without lidocaine. In 22 patients not receiving premedication, the addition of lidocaine to the contrast medium resulted in increased pain in 54.5% of patients and no difference in pain in 41% when compared to cont…
Kühne G E, Grünes J U, Knorr W, +6 more·Psychiatrie, Neurologie, und medizinische Psychologie
The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic…
Walker J E, Kay L W·International journal of oral surgery
A double-blind single dose trial was made of floctafenine 200 mg versus dihydrocodeine 30 mg in 100 patients complaining of jaw pain following oral surgery under general anaesthesia. There was no statistical difference between the two analgesics for the whole group, but dihydrocodeine was better for the relief of more…
Herforth A, Fligge U, Strassburg M·Deutsche zahnarztliche Zeitschrift
In a clinical, uncontrolled double blind test, the effect of a 1% HEDP containing toothpaste on the formation and degree of mineralization of supragingival calculus was examined in 50 subjects over two periods of three month each. Considering all subjects the HEDP-containing paste reduced the new formation of calculus…
McDowell M K, Spitz E·Annals of allergy
In a double-blind, crossover study to determine the efficacy of cromolyn sodium in chronic perennial allergic rhinitis five of 12 patients with significant sneezing problems and four of 12 patients with significant rhinorrhea showed major improvement after a four-week course of the drug. Nasal eosinophils disappeared i…
Delbarre F, Menkes C, Le Go A·Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles
A double-blind study (201 metacarpo and interphalangeal joints) on the effectiveness of the synoviorthesis shows the significant value of the 169-Erbium, compared with intra-articular placebo or corticotherapy. The treatment gives an improvement in 58% of the cases (p less than 0.01) (stade 1:80,7%), by destruction of…
Gerzof S G, Robbins A H, Unger G, +2 more·AJR. American journal of roentgenology
A double blind comparison of meglumine iodamide and Renografin-60 in bolus intravenous pyelography, using 50 ml of contrast or less, was conducted in 78 patients. Meglumine iodamide produced more dense opacifications, but it also produced a greater number of laboratory abnormalities. All were transient and mild. No ser…
Glatzel J·Medizinische Klinik
The author reports on a clinical study with the neuro-dynamic agent Encephabol (pyritinol, pyrithioxine) in a total of 317 patients with organic psychosyndrome of various genesis. The therapeutic effect obtained is related by the author to the mode of administration used (oral, parenteral and combined), to the dosage,…
Armstrong M L·The Medical journal of Australia
The results of a double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis are reported. Benefit was shown by statistically significant changes in the peak expiratory flow rate, ascultatory findings and sputum volume. Benefit was also demonstrated by changes in dyspnoea, sputum, consi…
Rada R T, Kellner R·Journal of the American Geriatrics Society
Thiothixene was used in a four-week double-blind placebo-controlled study of 42 geriatric patients with chronic organic brain syndrome (psychotic or nonpsychotic). The results, according to several rating measures, showed no significant difference between placebo and thiothixene. Side effects were mild and few. These d…
Savin R C·The Journal of international medical research
Halcinomide, a new topical fluorinated steroid was compared in a double-blind, simultaneous comparison with betamethasone valerate. Halcinoide was found to be superior in the treatment of psoriasis and equally effective as betamethasone valerate in the treatment of atopic dermatitis.
Pacquay M, Brasseur F·Proceedings of the Royal Society of Medicine
The effect of higher than usual dosages of haloperidol was studied in 38 chronic institutionalized schizophrenic patients for whom any hope of discharge had been abandoned. In 23 patients (61%) a marked or moderate improvement was observed. No striking differences were seen between patients simultaneously receiving or…
Kennedy A C·Rheumatology and rehabilitation
A double-blind cross-over trial of ketoprofen (200 mg daily) compared with placebo and aspirin (4 g daily) was carried out in 24 patients with rheumatoid arthritis. Ketoprofen was shown to be significantly more effective than placebo in terms of pain relief, degree and duration of morning stiffness, articular index and…