11,451,749 papers found

The study's aim was to assess the association between adolescent girls' recall of child sexual abuse (CSA) and prevalence of dating victimization in early romantic relationships and to explore the link between multiple trauma history and mental disorders. When demographics and teacher-reported behavioral problems durin…

BACKGROUND: Concerns about adverse consequences of early childbearing and risk of sexually transmitted diseases (STD) have renewed interest in the sexual behaviour of adolescents in developing countries, where they represent a large proportion of the population and are at highest risk. To date, little is known about th…

Cicchetti and Lynch have conceptualized ecological contexts as consisting of nested levels with varying degrees of proximity to the individual. These levels of the environment interact and transact with each other over time in shaping individual development and adaptation. With a sample of maltreated (n = 188) and nonm…

Cyclic progestin therapy has been widely advocated as an adjunct to postmenopausal estrogen replacement therapy to reduce the risk of endometrial carcinoma. Acceptance of this approach, however, appears to have preceded detailed evaluation of possible adverse side effects of progestins that could result in patient nonc…

INTRODUCTION: The dorsal striatum, comprised of the caudate and putamen, is implicated in the pathophysiology of psychosis spectrum disorders. Given the high concentration of dopamine receptors in the striatum, striatal dopamine imbalance is a likely cause in cortico-striatal dysconnectivity. There is great interest in…

A wide range of factors has detrimental impacts upon equity, diversity, and inclusion in clinical trials, amongst which participant burden can be significant. In addition to the potential physical burdens associated with investigational interventions, participants may face onerous demands related to factors like travel…

Fresenius Kabi has developed FKS518, a fully human monoclonal antibody biosimilar to denosumab. The clinical development program included two randomized comparative trials: a PK study in healthy volunteers and a safety and efficacy study in osteoporosis patients. The demonstration of similarity and equivalence between…

INTRODUCTION: Nerve agents have emerged as a global threat since their discovery in the 1930s, posing severe risks due to their inhibition of acetylcholinesterase and the subsequent accumulation of acetylcholine in nerve synapses. Despite the enforcement of the Chemical Weapon Convention to control chemical weapons, in…

BACKGROUND: Uncertainty continues to surround the relative benefits and harms of conventional coronary artery bypass grafting (CABG) and off-pump coronary artery bypass grafting (OPCABG). Possible reasons are that high-quality studies have not comprehensively examined relevant patient outcomes and have enrolled a limit…

PURPOSE: To use the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement checklist to critically evaluate the change in quality of observational trial reporting in the Journal of Hand Surgery American between 2005 and 2011. METHODS: A cross-sectional analysis of observational studies…

OBJECTIVE: To evaluate the progression-free survival (PFS) time in patients with early-stage and locally advanced prostate cancer and to compare the estimates provided by ChatGPT with actual survival data. METHODS: A retrospective analysis was conducted on patients diagnosed with early-stage/locally advanced prostate…

Peak oxygen consumption (Vo(2)) is a powerful prognostic predictor of survival in patients with chronic heart failure (CHF) because it provides an indirect assessment of a patient's ability to increase cardiac output (CO). However, many patients with CHF who undergo cardiopulmonary exercise testing are unable to perfor…

PURPOSE: The reasons for fractures in the elderly patients are multifactorial. Osteoporosis is considered to be the main pathology. Other reasons are the increase in fall frequency and the protective response to trauma. The most common sites at which these fractures occur are the hip, vertebra and distal radius. A comb…

Child maltreatment is a global public health and child rights crisis made worse by the ongoing COVID-19 pandemic. While understanding the breadth of the child maltreatment crisis is foundational to informing prevention and response efforts, determining accurate estimates of child maltreatment remains challenging. Alter…

OBJECTIVE: This article outlines the development and validation of the Informal Supporter Readiness Inventory (ISRI), based on the model developed by the present authors in (Davies, 2023). This scale assesses the readiness of informal supporters to intervene or provide support in situations of intimate partner violence…

Experience with an object's photograph changes 9-month-olds' preference for the referent object, confirming they can represent objects from pictures. However, picture-based representations appear weaker than object-based representations. The current study's first objective was to investigate age differences in object r…

BACKGROUND: This research explores the repercussions of the COVID-19 emergency on women's enablement worldwide, scrutinizing data spanning 93 nations between 2019 and 2020. METHODS: The investigation employs sectional data examination of various metrics pertinent to women's empowerment, encompassing the ratio of emplo…

BACKGROUND: Most nursing education programs prepare their students to embody humanism and caring as it is expected by several regulatory bodies. Ensuring this embodiment in students and nurses remains a challenge because there is a lack of evidence about its progressive development through education and practice. PURP…

Recent revisions to the Common Rule require that consent documents begin with a focused presentation of the study's key information that is organized to facilitate understanding. We surveyed 1,284 researchers working with older adults or individuals with Alzheimer's disease, supplemented with 60 qualitative interviews,…

Parental Reflective Functioning (PRF) refers to parents' capacity to view their child's and their own behavior considering inner mental states, like thoughts, desires, and intentions. This study's objective was to examine whether PRF acted as a moderator for the relationships between maternal depression and child inter…