1,557,822 papers found

New methods are now available to help select vehicles for topical corticosteroids. In the development of a new cream vehicle for flurandrenolide, the goal was a cream base with optimal solubility for release of the drug, minimal irritation potential, and no sensitizing preservatives. Vasoconstriction tests make selecti…

Blood absorption of tetracycline hydrochloride of various dispersity levels from capsules containing tetracycline alone or in combination with additives, such as magnesium carbonate and calcium salts was studied on humans. It was found that higher dispersity levels of tetracycline hydrochloride powder in capsules was n…

In a double-blind study, 28 patients for peripheral angiography received contrast injection both with and without lidocaine. In 22 patients not receiving premedication, the addition of lidocaine to the contrast medium resulted in increased pain in 54.5% of patients and no difference in pain in 41% when compared to cont…

The antidepressants desipramine and imipramine were compared within the framework of a multiclinical study performed under the conditions of a controlled clinical experiment. There has been found a time-different remission of affective symptoms, which was not detectable for the inhibition of drive. The tachythymoleptic…

A double-blind single dose trial was made of floctafenine 200 mg versus dihydrocodeine 30 mg in 100 patients complaining of jaw pain following oral surgery under general anaesthesia. There was no statistical difference between the two analgesics for the whole group, but dihydrocodeine was better for the relief of more…

In a clinical, uncontrolled double blind test, the effect of a 1% HEDP containing toothpaste on the formation and degree of mineralization of supragingival calculus was examined in 50 subjects over two periods of three month each. Considering all subjects the HEDP-containing paste reduced the new formation of calculus…

In a double-blind, crossover study to determine the efficacy of cromolyn sodium in chronic perennial allergic rhinitis five of 12 patients with significant sneezing problems and four of 12 patients with significant rhinorrhea showed major improvement after a four-week course of the drug. Nasal eosinophils disappeared i…

In a phase II trial, prednimustine was often efficient in treating chronic lymphoid leukaemia (CLL) patients and was also active in some patients with lymphosarcoma, melanoma and bronchus carcinoma. Tolerance was generally excellent, the most critical side effect being thrombocytopenia in the case of CLL.

A double-blind study (201 metacarpo and interphalangeal joints) on the effectiveness of the synoviorthesis shows the significant value of the 169-Erbium, compared with intra-articular placebo or corticotherapy. The treatment gives an improvement in 58% of the cases (p less than 0.01) (stade 1:80,7%), by destruction of…

The organizational and statistical concept of the cooperative randomized controlled clinical trial on gnotobiotic care and its effect in acute leukamia patients is described. The purpose is the clarification of the concept of the study and the comparison with other studies on the same subject. It is concluded that the…

The author reports on a clinical study with the neuro-dynamic agent Encephabol (pyritinol, pyrithioxine) in a total of 317 patients with organic psychosyndrome of various genesis. The therapeutic effect obtained is related by the author to the mode of administration used (oral, parenteral and combined), to the dosage,…

The results of a double-blind crossover trial of bromhexine (Bisolvon) in the treatment of chronic bronchitis are reported. Benefit was shown by statistically significant changes in the peak expiratory flow rate, ascultatory findings and sputum volume. Benefit was also demonstrated by changes in dyspnoea, sputum, consi…

Thiothixene was used in a four-week double-blind placebo-controlled study of 42 geriatric patients with chronic organic brain syndrome (psychotic or nonpsychotic). The results, according to several rating measures, showed no significant difference between placebo and thiothixene. Side effects were mild and few. These d…

Halcinomide, a new topical fluorinated steroid was compared in a double-blind, simultaneous comparison with betamethasone valerate. Halcinoide was found to be superior in the treatment of psoriasis and equally effective as betamethasone valerate in the treatment of atopic dermatitis.

The effect of higher than usual dosages of haloperidol was studied in 38 chronic institutionalized schizophrenic patients for whom any hope of discharge had been abandoned. In 23 patients (61%) a marked or moderate improvement was observed. No striking differences were seen between patients simultaneously receiving or…

A double-blind cross-over trial of ketoprofen (200 mg daily) compared with placebo and aspirin (4 g daily) was carried out in 24 patients with rheumatoid arthritis. Ketoprofen was shown to be significantly more effective than placebo in terms of pain relief, degree and duration of morning stiffness, articular index and…

Sympathomimetic amines have been used with the aim of abolishing uterine contractions. On the basis of results from an in vivo technique for testing the specificity and affinity of the beta2-receptor stimulating agents, salbutamol was used for a clinical trial. Five case histories were selected in order to illustrate t…

Azapropazone was investigated in a 2-week double-blind clinical out-patient trial against placebo in 23 patients with definite rheumatoid arthritis. The drug was given at a dose of 1200 mg. per day before food. At this dose level the drug was shown to have an antirheumatic effect in terms of pain relief, articular tend…

The inflammation and plaque-inhibiting effect of KAVOSAN was tested in 43 probands with gingivitis in two test series. Irrespective of the type of oral care, a statistically significant improvement in the degree of inflammation and a reduction of plaque were observed after application of the active agent when compared…