42,208 papers found

OBJECTIVE: To highlight key factors required to optimize multi-mechanistic approaches with oral combination treatments for the acute management of a migraine attack. BACKGROUND: Given the complex multi-factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compar…

AIM: To summarise the facilitators and barriers influencing the utilisation of mobile health (mHealth) for rehabilitation among older adults with hip fractures, family caregivers, and healthcare providers. METHODS: A total of five databases (PubMed, Cochrane Library, Embase, Web of Science Core Collection, and Ovid) w…

BACKGROUND: Thyroid eye disease (TED) is a disabling, organ-specific autoimmune disease that is a global health concern. Recently, certain biological agents have demonstrated unique advantages for the treatment of TED. Teprotumumab is an emerging biological agent used for TED treatment. This study assessed whether tepr…

Chronic inflammatory demyelination polyradiculoneuropathy (CIDP) is a rare autoimmune neuropathy generated by cellular and humoral immune responses. Its course can be chronic, progressive, monophasic, or relapsing-remitting. Misdiagnosis and inappropriate therapy are common in CIDP. Given the scarcity of integrative in…

INTRODUCTION: Gamification consists of the use of games in non-playful contexts. It is widely employed in the motor rehabilitation of neurological diseases, but mainly in adult patients. The objective of this review was to describe the use of gamification in the rehabilitation of children and adolescents with neuromoto…

OBJECTIVE: Systematization and generalization of data from domestic and foreign literature on alternative methods of treatment of sleep disorders in epilepsy. MATERIAL AND METHODS: The search for data from domestic and foreign literary sources was carried out in the electronic databases Medline (PubMed), Scopus, Web o…

OBJECTIVE: The associations of dietary vitamin C and E intake with depression remains conflicting. This meta-analysis of observational study was therefore employed to clarify the issue further. METHODS: An extensive literature review (PubMed, Web of Science and Embase) was performed in January 2022 to identify the obs…

INTRODUCTION: Cholangiocarcinoma (CCA) is the second most common hepatic malignancy. Progress and developments have also been made in the field of CCA management along with increasing scientific publications during the past decades, which reflect topics of general interest and suggest the future direction of studies. T…

Accidental falls in the elderly and their consequences are one of the leading causes of disability; they significantly reduce the quality of life and lead to loss of independence and impaired social functioning. This study presents selected issues regarding the causes of accidental falls and research tools for determin…

OBJECTIVE: To identify expected pharmacokinetic changes and provide practical recommendations for the medication management of chronic disease states after bariatric surgery. SOURCES OF INFORMATION: MEDLINE, EMBASE, PubMed, Scopus, and the Cochrane Library were searched. The search was limited to studies in human adul…

BACKGROUND: The majority of liver transplant recipients survive long term after the procedure. AIM: To assess if this positive outcome is associated with improved employment post-transplant. METHODS: A systematic review of publications between 2001 and 2016 was performed. A standard procedure was used to search for s…

BACKGROUND: Whether white-coat hypertension (WCH) is an innocent phenomenon is controversial. METHOD: In this study, we evaluated the association of WCH and the risk of cardiovascular diseases (CVDs) and mortality, stratified by baseline antihypertensive treatment status. Databases (PubMed, EMBASE, CINAHL Plus, Scopus…

BACKGROUND: In 2009 there were an estimated 2.6 million stillbirths worldwide. In the United States, a 2007 systematic review found little consensus about professional behaviors perceived by parents to be most helpful or most distressing. In the United Kingdom, a bereaved parents' organization has highlighted discordan…

Hysteroscopic adhesiolysis has become the preferred option for management of intrauterine adhesions (IUA). Use of estrogen as perioperative adjuvant therapy has been suggested for preventing recurrent adhesions. The primary objective of this article was to review the literature for evidence of the efficacy of estrogen…

INTRODUCTION: In the last 10 years the field of mitochondrial genetics has widened, shifting the focus from rare sporadic, metabolic disease to the effects of mitochondrial DNA (mtDNA) variation in a growing spectrum of human disease. The aim of this review is to guide the reader through some key concepts regarding mit…

Since the first report of erythromycin-resistant() in Arizona in 1994, macrolide-resistant strains have emerged worldwide, threatening pertussis control. This systematic review and meta-analysis aimed to quantify the prevalence and temporal trends of this resistance. Four databases (PubMed, Embase, Cochrane Library, We…

OBJECTIVE: Research on pulmonary diseases and environmental factors has expanded rapidly, yet the field remains fragmented across exposure categories, disease outcomes and disciplinary boundaries, and its overall knowledge structure has not been systematically characterized. METHODS: We conducted a bibliometric and kn…

BACKGROUND: Ivabradine was initially introduced for heart failure and coronary artery disease patients, with its interesting feature of heart rate reduction without reducing heart contractility or blood pressure. In recent years, however, the use of ivabradine evolved for arrhythmia, including for focal atrial tachycar…

Aging clocks based on routine clinical indicators have emerged as a cost-effective tool for assessing biological age. This systematic review aims to summarize the characteristics and critically appraise these available aging clocks. Studies that developed aging clocks for adults (≥18 years) based on routi…

BACKGROUND: Postmenopausal women experience accelerated ageing of arterial vessels and increased cardiovascular disease risk. Exercise training, as a non-pharmacological intervention, holds great value in improving cardiovascular issues such as arterial stiffness. OBJECTIVE: The present systematic review and meta-anal…