44,621 papers found

This systematic review with meta-analysis aimed to investigate the effects of physical exercise and physical activity on sleep quality and urinary incontinence in menopausal women and to assess the strength of evidence from randomized clinical trials. Following the PRISMA checklist, this study was registered in PROSPER…

BACKGROUND/OBJECTIVES: Alterations in systemic immune balance, reflected by changes in neutrophil and lymphocyte proportions, index a peripheral immune state relevant to central nervous system function. This systematic review and meta-analysis aimed to assess the differences in the neutrophil-to-lymphocyte ratio (NLR)…

BACKGROUND: Phenylketonuria (PKU) is a rare metabolic disorder requiring lifelong dietary management. While clinical stability hinges on strict treatment adherence, this adherence is largely sustained by unpaid family caregiving, particularly in pediatric contexts. Yet, the lived experience of caregivers remains concep…

OBJECTIVE: The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway is a core DNA-sensing axis in innate immunity and has been increasingly implicated in the pathogenesis of multiple Central Nervous System (CNS) disorders. This review summarizes current knowledge of cGAS-STING signali…

BACKGROUND AND OBJECTIVE: The rapid advancement of transbronchial endoscopic interventional techniques is profoundly transforming the diagnostic and therapeutic landscape of pulmonary malignant tumors. This article reviews high-quality, high-impact clinical studies on transbronchial diagnosis and treatment of pulmonary…

: Digital impression-taking techniques are widely used due to their many advantages. However, the accuracy of intraoral scanning in full-arch cases remains a matter of debate. The reliability of different digital implant impression techniques remains questionable in completely edentulous, full-arch cases. This review i…

OBJECTIVE: To evaluate the effects of isometric exercise training (IET) on arterial stiffness (AS) and endothelial function (EF) in middle-aged and older adults through a systematic review and meta-analysis. METHODS: We systematically searched PubMed, Cochrane Library, Embase, and Web of Science databases (up to Janua…

Beyond conventional optical coherence tomography (OCT)-based morphological classifications of diabetic macular edema (DME), an expanding range of OCT-derived biomarkers has been identified that reflect distinct pathophysiological mechanisms and may carry diagnostic, prognostic, and therapeutic relevance. We summarize c…

BACKGROUND/AIM: Tremor arises from mechanical, reflex, or central oscillatory mechanisms. Transcranial magnetic stimulation (TMS) can transiently perturb ongoing tremor and enables the quantitative assessment of phase resetting, offering circuit-level insight into tremor types. Although numerous studies have applied TM…

BACKGROUND: Over the last decade, remote technological initiatives for obstetric antenatal care have rapidly developed. However, variation in outcome reporting can preclude effective data synthesis. A remedy for this is to develop of a core outcome set (COS). However, prior to this, it is necessary to examine the heter…

Congenital abnormalities (CAs) are a major contributor to perinatal mortality and morbidity in India, particularly among abortuses and stillbirths. Despite the Ministry of Health and Family Welfare, India, introducing stillbirth surveillance guidelines, national data on the burden of CAs remain limited. This systematic…

Work-related musculoskeletal disorders are occupational conditions that result from the excessive use of the musculoskeletal system, combined with insufficient time for physiological recovery. These disorders remain prevalent in the automotive industry, particularly on assembly lines, and directly impact workers' healt…

BACKGROUND: Dental pulp sustains oral health through dentine formation, sensation, nutrition and defence. Beyond these classical roles, pulpal nerves have emerged as key coordinators of immune responses and tissue repair. While traditionally viewed as limited to sensory and vascular regulation, recent advances reveal t…

PURPOSE: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in older adults, with its prevalence rising globally. This review aims to explore the potential of Efdamrofusp alfa (EA), a novel bispecific decoy receptor fusion protein targeting both VEGF and complement pathways, in treating…

BACKGROUND: The erector spinae plane (ESP) block has gained attention as a regional anesthesia technique for pain management in vertebral surgeries. This umbrella review synthesizes data from systematic reviews (SRs) and meta-analyses to evaluate the effectiveness of the ESP block in reducing postoperative opioid consu…

BACKGROUND AND AIM: Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome caused by pathogenic variants in the NF1 gene. It exhibits highly variable and unpredictable clinical manifestations involving multiple organ systems, with café-au-lait macules and multiple neurofibromas being…

BACKGROUND: Tuberous Sclerosis Complex (TSC) is a multisystemic neurocutaneous disorder caused by pathogenic loss of function variants in the tumour suppressor genes TSC1 and TSC2. The resultant hamartomas confer significant medical risks by disruption of local tissues. Risk of mortality in TSC is known to be elevated,…

The purpose of this study was to determine the effect of painful versus nonpainful exercise on pain, disability, and other patient-reported outcomes in adults with chronic musculoskeletal pain.This study is an intervention systematic review with meta-analysis.Electronic databases (CENTRAL, EMBASE, CINAHL, PubMed, and P…

BACKGROUND: This network meta-analysis aims to evaluate the comparative efficacy of non-pharmacological interventions on Parkinson's disease (PD) with constipation. METHODS: A comprehensive search was conducted in seven major databases (CINAHL, the Cochrane Central Register of Controlled Trials [CENTRAL], Embase, PubM…

PURPOSE: Improving cardiorespiratory fitness (CRF) before and after colorectal cancer surgery may improve postoperative outcomes. This systematic review and meta-analysis evaluated the effects of perioperative exercise therapy (aerobic, resistance, mind-body, flexibility, or mixed exercise (combined aerobic and resista…