Research in psychopharmacology. Report of a WHO scientific group.
World Health Organization technical report series
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World Health Organization technical report series
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The Journal of the Kansas Medical Society
Abstract not available
Pellicer Adelina, Greisen Gorm, Benders Manon, +16 more·Neonatology
UNLABELLED: Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rStO2) reflects venous oxygen saturation. If cerebral metabolism is stable, rStO2 can be used as an estimate of cerebral oxygen delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the burden of hypo…
Wallace D J, Navarra S, Petri M A, +10 more·Lupus
Safety data were pooled and analyzed from one phase 2 and two phase 3 double-blind, placebo-controlled, repeat-dose systemic lupus erythematosus (SLE) trials of belimumab 1, 4 (phase 2 only), and 10 mg/kg. Types and rates of adverse events (AEs) were similar across treatment groups. Rates of patients experiencin…
Fraser P M, Doll R, Langman M J, +2 more·Gut
The effects of a new carbenoxolone analogue (BX24), zinc sulphate, and vitamin A on the healing of gastric ulcer have been assessed in a multifactorial clinical trial conducted in out-patients treated for four weeks.Forty-eight patients completed the trial. Three groups of eight patients were given respectively 300, 60…
Colleoni M, Price K N, Castiglione-Gertsch M, +3 more·Lancet (London, England)
Combined chemotherapy for early breast cancer with cyclophosphamide, methotrexate, and fluorouracil has low associated mortality, but related deaths were seen among women aged 65 years or older in International Breast Cancer Study Group trials.
Zerbib M, Payan C·Urology
Abstract not available
Moyé L A, Davis B R, Hawkins C M·Statistics in medicine
Clinical trials often involve a variety of clinical and laboratory measures that are used as endpoints and sometimes two of these measures are combined in one endpoint. When the individual components of such a combined endpoint are 'time to event' measurements, the analysis is straightforward if each of the components…
Khodzhaeva N I·Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952)
The results of the treatment of three groups of patients with chronic alcoholism are compared. Group I (n = 26) received essential combined with hemoperfusion, group II (n = 18) placebo combined with hemoperfusion and group III (n = 20) was on teturam. It has been established that as compared with other treatment measu…
Topol E J·Cardiology clinics
The past 5 years have witnessed an explosion in the amount of published clinical trial data for the use of intravenous thrombolytic therapy for acute myocardial infarction. This article reviews the properties of the various agents, the experiences of each in prospective, randomized clinical trials, and the future direc…
Ferrari M, Olivieri M, De Gasperi M, +1 more·Annals of allergy
The protective effect of nifedipine and diltiazem on methacholine-induced bronchoconstriction was studied in 12 allergic asthmatic patients. Nifedipine significantly but weakly attenuated airway reactivity to methacholine, whereas no protective effect was shown by diltiazem. We conclude that the two calcium antagonists…
Alton E W, Johnson M, Turner-Warwick M·Respiratory medicine
Seven patients with fibrosing alveolitis who failed to respond to prednisolone and cyclophosphamide and were deteriorating, were treated with cyclosporin A. An initial favourable response was seen but was not maintained. When compared to a control population, matched for the extremely severe disease present in the trea…
Tanashkin S F, Starosel'skiĭ D V, Mazyrko E D, +2 more·Klinicheskaia meditsina
The effectiveness of intensification of diuresis by means of hypothiaside and furosemide has been studied during treatment of 135 patients with viral hepatitis A and B. Both these agents were found to posses the same effect which was manifested by lessening of the intoxication syndrome, total blood toxicity and convale…
Suzuki M, Hirasawa Y, Hirashima K, +7 more·Contributions to nephrology
Abstract not available
Myrhöj T, Olsen O, Wengel B·Diseases of the colon and rectum
The effect of neostigmine on postoperative intestinal paralysis in 90 patients was investigated in a controlled study. Neostigmine, 0.5 mg, was administered intramuscularly every third hour on the third day after laparotomy, either until passage of flatus or stools was observed, or until a total of three injections wer…
Biary N, Pimental P A, Langenberg P W·Neurology
We studied the effect of clonazepam in a double-blind trial on 12 parkinsonian patients with hypokinetic dysarthria. Speech samples were judged on 14 of the dimensions used in the Mayo Clinic dysarthria study. Of the 11 patients who completed the study, 10 showed improvement. The effective dosage of clonazepam was 0.25…
Abdalla A, Mazur N A, Ivanova L A, +1 more·Kardiologiia
The efficiency of various combinations of antiarrhythmic agents (quinidine, etmozin, disopyramide, mexitil, and allapinine) was assessed in 24 cases of frequent ventricular and supraventricular extrasystoles, where treatment with one of the above listed drugs had been ineffective. Combined use of the drugs produced ant…
Juhlin L, Gibson J R, Harvey S G, +1 more·International journal of dermatology
Abstract not available
Fishel S, Webster J, Faratian B, +1 more·Journal of in vitro fertilization and embryo transfer : IVF
General anesthesia has been used for the replacement of human conceptuses after in vitro fertilization (IVF). Two adjuvants, enflurane and halothane, have been compared. Halothane significantly reduced the incidence of implantation compared to enflurane. In 356 replacements, the incidence of implantation for enflurane…
Trope G E, Britton R·The British journal of ophthalmology
Humphrey automated threshold perimetry (Program 30-2) was performed on 42 eyes of 25 patients with glaucoma to determine both the sensitivity and specificity of automated perimetry in detecting glaucomatous visual field defects. Automated perimetry sensitivity was 90.38%, while automated perimetry specificity was 91%.…