42,208 papers found

INTRODUCTION: Irritable bowel syndrome (IBS) and functional abdominal pain - not otherwise specified (FAP-NOS) are amongst the most common disorders affecting children worldwide, often associated with a lower quality of live, anxiety, and depression. The underlying mechanisms of these conditions remain poorly understoo…

BACKGROUND: Thyroid-stimulating hormone (TSH) suppression therapy after surgery is recommended for patients with differentiated thyroid cancer (DTC) at risk of recurrence; however, evidence, including all stages of the disease, is inconclusive. A meta-analysis was conducted to assess the efficacy of postoperative treat…

BACKGROUND: Research concerning the genetic risk for dementia has recently been headed towards new directions. Novel findings from genome-wide association studies have highlighted the association of Alzheimer's disease incidence with many gene polymorphisms, apart from the Apolipoprotein-E genotype. The identification…

OBJECTIVE: We conducted this present meta-analysis to examine the difference in efficacy and safety of intravitreal dexamethasone implant (DEXI) in vitrectomized and non-vitrectomized eyes. METHODS: All types of comparative studies published on PubMed, CENTRAL, Scopus, and Embase databases till March 10, 2025 were inc…

BACKGROUND: Anemia is a major health concern in India, ranking second in maternal mortality and exhibits a higher prevalence compared to many other developing nations. This study aims to analyze prevalence of anemia across age groups using systematic review and meta-analysis. METHODS: The present systematic review and…

PURPOSE: This study aimed to summarize the existing English-language literature on central nervous system (CNS) meningeal melanocytomas in children, and additionally describe our institutional case report. METHODS: PubMed database was screened on September 2, 2024, for English-language papers reporting on pediatric pa…

Type 2 diabetes mellitus (T2DM) is a major global health issue, affecting millions and leading to significant healthcare costs. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have emerged as a potential treatment option. Still, their effects on body weight, body mass index (BMI), and body composition compared to oth…

INTRODUCTION: Chronic disease self-management (CDSM) is a vital component of congestive heart failure (CHF) programmes. Recent CHF guidelines have downgraded CDSM programmes citing a lack of gold-standard evidence. This protocol describes the aims and methods of a systematic review to collate and synthesise the publish…

BACKGROUND: Given the growth in research examining the effects of psychotherapy on social anxiety disorder (SAD), an up-to-date comprehensive meta-analysis in this field is needed. METHODS: We selected studies from a database of randomized trials (RCTs) on psychotherapies for anxiety disorders (last updated search of…

BACKGROUND: Accurate diagnosis of latent infections prior to conversion total hip arthroplasty (THA) following internal fixation of femoral neck fractures is crucial for successful surgical outcomes. This systematic review aimed to provide a comprehensive evaluation of the current literature regarding the diagnosis of…

INTRODUCTION: Examining the retina represents a non-invasive method to evaluate abnormalities pertaining to the nervous and cardiovascular systems. Evidence indicates that physical activity is a non-pharmacological intervention to enhance the nervous and cardiovascular systems. However, little is unknown about its effe…

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the commonest chronic liver disease worldwide. We estimated the prevalence and predefined associated factors for NAFLD among South-Asian adults. METHODS: We searched PubMed and included descriptive, epidemiological studies with satisfactory methodology, reportin…

BACKGROUND: Coronavirus disease 2019 (COVID-19) is a viral infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although respiratory manifestations have received greater visibility during the pandemic caused by this virus, numerous neurological complaints related to coronavirus 2 infection…

Glutaric aciduria type 1 (GA1) is an autosomal recessive disease frequently leading to dystonia. Deep brain stimulation (DBS), intrathecal baclofen (ITB), and intraventricular baclofen (IVB) are the current interventional treatment options for refractory dystonia. We performed a scoping review, individual patient data…

BACKGROUND: Neuroimaging has helped us learn about the stages of brain development from infancy to maturity. Neuroimaging helps physicians diagnose mental illnesses and find novel treatments for them. It can distinguish depression from neurodegenerative diseases or brain tumors, and it can reveal structural defects tha…

OBJECTIVES: To identify and synthesize the existing evidence on the effectiveness and safety of epidural spinal cord stimulation (SCS) for improving motor and voiding function and reducing spasticity following spinal cord injury (SCI). METHODS: This scoping review was performed according to the framework of Arksey and…

BACKGROUND: Myofascial pain syndrome (MPS) is a common musculoskeletal pain and dysfunction, which is characterised by myofascial trigger points. Therapeutic physical modalities, as potentially effective treatment options, are commonly used in the clinical setting for the patients with MPS. OBJECTIVE: This systematic…

BACKGROUND: Quality of Life (QoL) is an important outcome in mental disorders. We investigated whether antidepressant pharmacotherapy improved QoL vs. placebo among patients with MDD. METHODS: Systematic literature search in CENTRAL, Medline, PubMed Central, and PsycINFO of double-blind, placebo-controlled RCTs. Scree…

OBJECTIVES: In this systematic review, we aim to identify laboratory biomarkers that predict response to tumour necrosis factor inhibitors (TNFi) in patients with rheumatoid arthritis (RA). METHODS: EMBASE, PubMed and Cochrane Library (CENTRAL) were searched for studies that presented predictive accuracy measures of l…

PURPOSE: Cataract surgery in patients with uveitis is challenging, and postoperative inflammation control is crucial for successful outcomes. No consensus exists regarding the optimal method of controlling postoperative inflammation. In this systematic review and meta-analysis, we compared the outcome of intravitreal i…