1,546,953 papers found

The incidence of sepsis, mortality due to sepsis, total mortality, and minor infections was evaluated in a group of 46 premature newborn infants who were treated with intravenous immunoglobulins. They were compared with an untreated control group. No significant differences were observed between the two groups.

An immunotherapy protocol based on intracranial implantation of stimulated, autologous lymphocytes into the tumor bed following surgical debulking of malignant glioma is described. Phase I clinical trials in human patients are now in progress. Preliminary data representing the first 39 patients treated are presented br…

The effectiveness of levodopa in the treatment of restless legs was assessed in a double-blind trial. 20 patients were given levodopa and lactose on alternate days. Treatment was continued until patients stated a preference for one of the treatments or were unable to discriminate between the two. 17 patients preferred…

A randomized sequential test is considered for deciding whether prophylactic antibiotic is successful in reducing infection rates following neurosurgical operations. The test is of the curtailed "gambler's ruin" type. Its operating characteristics are obtained and tabulated, and the actual medical experiment is describ…

A clinical protocol outline of a study randomizing prednimustine v doxorubicin in patients with metastatic breast cancer is presented. The study has just been initiated, and no results are available at the present time. Unique features of this clinical trial are discussed, including the correlation of objective paramet…

A double-blind trial comparing the effect of Permixon (160 mg bd) against placebo in the treatment of benign prostatic hypertrophy is described. In both groups a significant improvement in flow rate and subjective assessment of symptoms was seen. There was no significant difference between the results of treatment in e…

"Dermodress" is a new temporary biological dressing (heterograft) composed of a pure neonatal bovine collagen I. The authors present their first trial with this skin substitute. Ten consecutive patients who required skin grafts were included in the pilot test group. The "Dermodress" was tested on their donor sites and…

In patients undergoing bilateral Keller's arthroplasty the effect of injecting a long acting local anaesthetic into the pseudoarthrosis immediately after skin closure was compared to placebo into the other side in twenty patients. In a controlled double blind prospective trial, local anaesthetic proved to provide signi…

Fifteen women with moderate to severe premenstrual symptoms, defined and graded according to a recently developed scoring system, took part in a double blind study of the effect of progesterone on premenstrual symptoms. The dosage was 100 mg progesterone twice daily delivered in vaginal pessaries. The women were improv…

The wearable drug pump HDL-2M has been clinically tested. It is of small dimensions, high reliability and easy-to-use. By means of the unit insulin was administered to patients suffering from insulin-dependent diabetes mellitus. With the HDL-2M, the therapy of the diabetes has been shown to be more effective than the t…

The Epilepsy Branch of the National Institute of Neurological and Communicative Disorders and Stroke has responded to the need for new, more effective, and less toxic antiepileptic drugs by cooperating with pharmaceutical companies in key areas of development. The ADD Program screens large numbers of compounds for anti…

Eighteen children between 6 and 14 years of age with perennial asthma were studied over two four-week treatment periods. Ipratropium bromide, given in addition to their current treatment, was compared with placebo using a double-blind crossover technique. The period of treatment with ipratropium was associated with a s…

Drug trial with CIBA 1906 was conducted in 50 cases of lepromatous leprosy who were intolerant to dapsone therapy. Drug was tolerated well and lepra reactions were infrequent and mild. Clinical improvement was seen in 72% cases whereas no appreciable change was detected in 28% cases. An average reduction of 0.4 in BI w…

Acute spinal cord injury patients were assigned alternately to a control and a heparin prophylaxis group to determine the effect of 5,000 micro sodium heparin subcutaneously every 12 hours on the incidence of venous thrombosis as detected by impedance plethysmography of the lower extremities. Venous thrombosis was unex…