376,071 papers found

INTRODUCTION: Systematic reviews are crucial for informing health decisions and supporting evidence-based policymaking. Reporting guidelines aim to reduce ambiguity and confusion while promoting clarity, completeness, and transparency in reporting. Our study aimed to assess the completeness of reporting of diagnostic t…

We conducted a systematic review and network meta-analysis to examine the overall and comparative cardiovascular outcomes of bexagliflozin, ertugliflozin, and sotagliflozin in type 2 diabetes patients. We included phase 3 or higher randomized controlled trials sourced from four databases: ClinicalTrials.gov, PubMed, Co…

OBJECTIVE: To examine the nonlinear dose-response of overall and modality-specific exercise interventions on motor skill improvement in children and adolescents with cerebral palsy (CP) using a Bayesian model-based network meta-analysis. METHODS: Randomized controlled trials (RCTs) involving participants aged ≤…

INTRODUCTION: Tirzepatide, a glucagon-like peptide-1 receptor agonist (GLP1RA) and glucose-dependent insulinotropic-peptide (GIP), has shown efficacy regarding weight-loss. METHODS: Systematic review and network meta-analysis of randomized controlled trials. MEDLINE, EMBASE, and Cochrane CENTRAL databases were searche…

OBJECTIVES: This systematic review with network meta-analysis (NMA) evaluated whether three-dimensional (3D) printed resin-based composites (RBCs) intended for long-term dental restorations perform similarly or superiorly to conventional restorative materials. DATA SOURCES: The review followed the PRISMA extension for…

OBJECTIVES: To evaluate the effects and morbidities associated with perioperatively administered analgesics in paediatric patients undergoing tonsillectomy. DESIGN AND SETTING: Systematic review and network meta-analysis (NMA) of randomised controlled trials. PARTICIPANTS: Paediatric patients undergoing tonsillectomy…

INTRODUCTION: Overweight and obesity are major global health issues, increasing disease risk and straining healthcare systems. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are effective for weight loss but cause gastrointestinal side effects, affecting adherence. Research often focuses on diabetics, leaving a…

IMPORTANCE: Retractions are rising in the scientific literature, increasing the risk of reusing unreliable results. OBJECTIVES: To identify reports of systematic reviews that included retracted studies in their meta-analyses, and to assess the impact of these retracted studies on the results. DESIGN, SETTING, AND PAR…

BACKGROUND: Statins have been shown to reduce the risk of all-cause mortality among individuals with clinical history of coronary heart disease. However, it remains uncertain whether statins have similar mortality benefit in a high-risk primary prevention setting. Notably, all systematic reviews to date included trials…

STUDY OBJECTIVE: To determine the risk of liver toxicity from the long-term administration of methotrexate in patients with rheumatoid arthritis or psoriatic arthritis. DESIGN: A meta-analysis of 15 studies examining the relationship between long-term, low-dose methotrexate administration and biopsy evidence of liver…

INTRODUCTION: Cluster headache (CH) is a severe unilateral trigeminal autonomic cephalalgia with limited well tolerated therapies. Calcitonin gene related peptide monoclonal antibodies, including galcanezumab, fremanezumab, and eptinezumab, have established efficacy in migraine and are under evaluation in CH. This stud…

BACKGROUND: Relapsing-Remitting Multiple Sclerosis (RRMS) is a chronic inflammatory demyelinating disease affecting the central nervous system, characterized by complex pathogenesis and increasing annual incidence rates. Although current clinical interventions for RRMS are diverse, there remains a relative scarcity of…

INTRODUCTION: Sarcopenic obesity is highly prevalent among older adults and is associated with adverse clinical outcomes. However, direct comparative evidence on the relative efficacy and safety of different exercise-based rehabilitation strategies, with or without nutritional supplementation or high-protein intake, re…

BACKGROUND: Cervical cancer is the fourth most common malignancy among women worldwide. Despite curative-intent treatment, 10%-30% of patients experience treatment failure due to persistent or recurrent disease within five years. Immune checkpoint inhibitors (ICIs) have shown clinical benefit in phase 3 trials, yet no…

BACKGROUND: This study attempted to assess the efficacy and safety of different herbal injections in combination with conventional therapy (CT) for the treatment of postinfarction ventricular remodeling using a net meta-analysis. METHODS: The search was conducted as of April 2024 in the China Knowledge Network Databas…

In a recent review of nonbehavioral child and adolescent psychotherapy, it was concluded that the magnitude of methodological flaws in this body of research precluded an evaluation of effectiveness. However, recent quantitative reviews of child and adolescent therapy have concluded that nonbehavioral therapy is relativ…

Issues in the statistical evaluation for therapeutic efficacy of surgical adjuvant modality therapy on the patients suffering from gastrointestinal cancers were mentioned as follows: 1) When a therapeutic effect is evaluated, it is important that a well-controlled, randomized trial should be requested under the statist…

A review of recent phase II and III studies in advanced gastric carcinoma is presented. Several combination regimens have been developed with high activity in locally advanced and metastatic disease. Among them are etoposide plus adriamycin plus cisplatin (EAP), etoposide plus 5-fluorouracil plus leucovorin (ELF), cont…

Between 1970 and 1988, reports were published about two ecological studies, six case-control studies and one cohort study that evaluated the relationship between methylxanthine consumption and the risk of ovarian cancer. Because of the limitations of ecological studies, no inferences are based on them. All of the case-…

Monotherapy of hypertension should be the goal of treatment. Even in the elderly hypertensive patient there is a good response to monotherapy with angiotensin-converting enzyme inhibitors as well as to diuretics and calcium channel blockers, despite the low plasma renin activity seen in the elderly. Adverse effects on…