5,042,690 papers found

BACKGROUND: Non-surgical interventions for adolescents with idiopathic scoliosis remain highly controversial. Despite the publication of numerous reviews no explicit methodological evaluation of papers labeled as, or having a layout of, a systematic review, addressing this subject matter, is available. OBJECTIVES: Ana…

PURPOSE: In clinical trials, the selection of appropriate outcomes is crucial for the assessment of whether one intervention is better than another. Selection of inappropriate outcomes can compromise the utility of a trial. However, the process of selecting the most suitable outcomes to include can be complex. Ideally,…

Sepsis remains a leading cause of mortality worldwide, and extracorporeal blood purification has been widely implemented despite ongoing uncertainty regarding its survival benefit. We conducted an umbrella review of 42 systematic reviews and meta-analyses evaluating mortality across major extracorporeal blood purificat…

BACKGROUND: The introduction of systematic reviews in medicine has prompted a paradigm shift in employing evidence for decision-making across various fields. Its methodology involves structured comparisons, critical appraisals, and pooled data analysis to inform decision-making. The process itself is resource-intensive…

AIM: To provide an overview of assessment methods and tools to evaluate postgraduate critical care nursing students' competence in clinical placement and to identify recommendations for future assessment methods. BACKGROUND: The purpose of postgraduate critical care nursing education is to educate professional, compet…

INTRODUCTION: Lung cancer (LC) is the most common cause of cancer death in the world and associated with significant economic burden. We conducted a review of published literature to identify prognostic factors associated with LC survival and determine which may be modifiable and could be targeted to improve outcomes.…

BACKGROUND: Acute low back pain is associated with pain and disability, but symptoms are often self-healing. The effectiveness of exercise therapy for acute low back pain remains uncertain with conflicting evidence from systematic reviews. The aim of this systematic review of systematic reviews was to assess the overal…

OBJECTIVE: This review aimed to evaluate the effectiveness of strategies to reduce risky alcohol consumption among youth living in rural and remote areas. INTRODUCTION: Youth living in rural and remote areas are more likely to drink alcohol and experience alcohol-related harm than youth living in urban locations. This…

Empirical research on the Gateway Belief Model (GBM) has flourished in recent years. The model offers a dual-process account of how attitude change happens in response to normative cues about scientific agreement. A plethora of correlational and experimental evidence has emerged documenting the positive direct and indi…

Properly conducted meta-analyses that are based on systematic reviews of the literature allow the conclusive synthesis of accumulating scientific evidence. Systematic reviews, with or without meta-analyses, offer a more objective appraisal of the available evidence compared with traditional narrative reviews. Combining…

The growth of new knowledge continues to advance the surgical disciplines, and several types of literature reviews attempt to consolidate this expansion of information. Meta-analysis is one such method that integrates findings on the same subject from different studies. Within surgery, there is a wealth of literature o…

Selection and evaluation of evidence to identify the most effective treatment modalities is a difficult process. Randomized controlled trials are well accepted as the least biased means of evaluating medical, surgical, screening or preventive manoeuvres. The most commonly used statistical strategy to pool results from…

As a result of the rapid advances in technology and the large volume of literature, healthcare decisions have become more complex. In response to this, increasing emphasis has been placed on basing these decisions on the best available research evidence. Systematic reviews are now accepted as the most reliable way by w…

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is closely linked with obesity and the prevalence of NAFLD is about 17% to 33% in the Western world. There is a strong association of NAFLD with insulin resistance and, hence, insulin sensitisers have been tried. This systematic review examined the clinical effectiv…

Immunotherapy is a treatment modality that has a broad and rapidly growing range of applications to treat both chronic and acute diseases, including rheumatoid arthritis, Crohn disease, cancer, and COVID-19. Emergency physicians must be aware of the breadth of applications and be able to consider the effects of immunot…

Sickle cell disease and homozygous β-thalassaemia are common haemoglobinopathies in Oman, with many implications for local healthcare services. The transfusions of such patients take place in many hospitals throughout the country. Indications for blood transfusions require local recommendations and guidelines to…

INTRODUCTION: Nursing practice is continuously evolving in response to global health care need, sociopolitical culture, and advancing medical knowledge necessitating ongoing evaluation of professional practice. The purpose of this state of this science paper was to explore current perceptions of nursing and critique th…

Adenocarcinoma ex goblet cell carcinoid is a rare neoplasm of appendiceal origin that contains features of both carcinoid tumor and adenocarcinoma. We report on a case of a 45-year-old woman, post-renal transplant who presented with ovarian metastases from this tumor. This appears to be the first report of an adenocarc…

The presence of subependymal nodular heterotopia and cortical dysgenesis has been infrequently reported in patients with encephalocele. The majority of these patients were found to have posterior encephaloceles. We report a case of a Hispanic female with a frontoethmoidal encephalocele who developed epilepsy at 15 year…