5,081,904 papers found

OBJECTIVE: The purpose of this review is to summarize the techniques used for network analysis of multimorbidity to inform development of a standard methodology. INTRODUCTION: There is a growing trend of using network analysis to investigate relationships between chronic illnesses in people with multimorbidities. Howe…

The objective of this review is to determine which 270-degree fundoplication procedure has a better outcome in patients with chronic or refractory gastroesophageal reflux disease (GERD). This review will identify the fundoplication approach for chronic or refractory GERD that provides better reflux control with minimal…

The objective of this scoping review is to investigate the outcomes measured and reported in trials of children with refractory epilepsy treated with ketogenic diet therapy. The scoping review will aim to list the outcomes and map the associated components including intervention (type of ketogenic diet therapy), defini…

The exponential growth of the systematic review methodology within health has been mirrored within medical education, allowing large numbers of publications on a topic to be synthesized to guide researchers and teachers. The robust, transparent and reproducible search methodologies employed offer scholarly rigor. The s…

BACKGROUND: Achilles tendinopathy is one of the most common overuse injuries in recreational and competitive runners, yet the clinical significance and frequency of abnormal sonographic characteristics in runners remains unclear. This paper presents a protocol for a systematic review which aims to assess existing liter…

High cost for systematic review of biomedical literature has generated interest in decreasing overall workload. This can be done by applying natural language processing techniques to 'automate' the classification of publications that are potentially relevant for a given question. Existing solutions need training using…

Digital health technologies (DHTs) have revolutionized clinical trials, offering unprecedented opportunities to streamline processes, enhance patient engagement, and improve data quality. Growing technology device and broadband access are contributing to the increasing number of DHT-enabled trials. Ideally, DHTs have t…

BACKGROUND: Anorexia nervosa is characterized by a severe restriction of caloric intake, low body weight, fear of gaining weight or of becoming fat, and disturbance of body image. Pathogenesis of the disorder may include genetic predisposition, hormonal changes and a combination of environmental, psychosocial, and cult…

The boom and constant transformation of biomedical research have led to the development of different electronic systems or platforms that allow researchers to respond to market demands and clinical research governance. The objective of this scoping review is to map and synthesize existing literature on data capture, co…

INTRODUCTION: Objective and accurate dietary monitoring is critical for comprehensive dietary assessment and improving nutritional health outcomes. The rapid advancement of wearable sensing technology presents a promising solution for effective dietary monitoring by reducing recall bias and enhancing user convenience,…

BACKGROUND: Cancer pain management is critical, especially at advanced stages. This is particularly important in Africa as most cancers are typically diagnosed at advanced stages. Given the central role of adequate pain management in advanced cancer care, this scoping review aims to examine the utilisation of patient-c…

OBJECTIVE: The objective of this review is to synthesize qualitative evidence regarding the experiences of parents and prospective parents when receiving a diagnosis of Down syndrome for their child in the perinatal period. INTRODUCTION: Increased awareness of parental experiences when receiving a Down syndrome diagno…

INTRODUCTION: Bipolar disorder (BD) is a severe mental health disorder that affects 2% of the adult population. Individuals with this disorder are at a higher risk for morbidity and functional difficulties. They may also experience significant challenges in their activities of daily living (ADLs). This systematic revie…

OBJECTIVE: The objective of the systematic review is to summarize the incidence, prevalence, risk factors and health consequences of polypharmacy in adults in South Asia. INTRODUCTION: Several studies have been conducted in South Asia on the incidence, prevalence, risk factors and health consequences of polypharmacy i…

BACKGROUND: Osteoporosis is a global high prevalence of chronic metabolic disease with serious disability-adjusted life years losing. Acupuncture is used to treat osteoporosis broadly in China and other countries although the evidence on effectiveness cannot give a certain answer. The aim of this systematic review prot…