1,546,953 papers found

Over 40 published and unpublished articles on double-blind controlled clinical trials with the local application of benzydamine as an antiinflammatory drug were reviewed with special reference to the randomization of patients, the description of the disease entity, the clinical trial and its statistical analysis. It wa…

In this report of a double-blind placebo-controlled trial of steroid injections for supraspinatus tendonitis, there was no statistical difference in the improvement in pain score between the two groups at 2 and 8 weeks of follow-up or in analgesic consumption. This trial casts further doubt on the efficacy of such trea…

Piroxicam 20 mg daily was compared with naproxen 1000 mg daily in a double-blind cross-over study of 24 patients with rheumatoid arthritis. A comparison was also made with the pre-trial medication. The effect of the pre-trial medication, piroxicam and naproxen, were found to be similar. The side-effects of piroxicam an…

Oral versus intravenous antibiotic therapy of severe erysipelas was compared in a controlled trial of 60 patients. No clinical benefit of intravenous therapy was found, as evaluated by fever duration, hospital stay and sick leave. Untoward reactions were comparable between the groups. No difference in recurrence was fo…

A multicentre collaborative clinical trial has been made at one centre in each of six countries to decide if the potency of allergen extracts can be determined satisfactorily by skin-prick tests in man. Although there was considerable variation in potency of antigen when determined in different patients, if a sufficien…

A prospective, uncontrolled clinical trial was conducted to test the safety and efficacy of intramuscular chlorpromazine (1 mg/kg) in the acute, outpatient treatment of migraine. One hundred adult patients were included in the study. There was complete relief of both pain and nausea/emesis symptoms in 96 patients withi…

THIP, 4, 5, 6, 7-tetrahydroisoxazolo (5,4-) pyridin-3-ol, is a GABA-agonistic drug with analgesic effect, but apparently without respiratory depressant properties in awake subjects. The effect of THIP on the CO2 ventilation response was tested before, during and at the end of halothane anaesthesia in six male patients…

Twelve healthy males participated in a trial to determine whether furosemide diuresis and its effects on electrolyte excretion patterns, aldosterone concentrations and renin activity are subject to diurnal variations. Six treatments were give: placebo at 07h00, 13h00 and 19h00 and furosemide 40 mg at 07h00, 13h00 and 1…

Treatment of onychomycosis is usually unsatisfactory. A small clinical trial using a solution of miconazole (Daktarin; Janssen) in alcohol was undertaken to assess its potential in this difficult condition. Ten unselected patients completed the 32-week trial and the results, irrespective of whether the infecting organi…

The on-going study by the European Working Party on High Blood Pressure in the Elderly (EWPHE) is described and the results in patients receiving either placebo or active treatment (hydrochlorothiazide plus triamterene, with the addition of methyldopa if necessary) are discussed. Over the 5-year period assessed, there…

The number of intravenous injections of hyoscine-N-butylbromide (Buscopan) or glucagon required to maintain relaxation of the duodenum during endoscopic retrograde cholangiopancreatography (ERCP) were compared in a double blind trial of 55 patients. There was no significant difference in the number of injections. Serum…

In a crossover study bumetanide, 2 to 6 mg/d, was compared with furosemide, 40 to 160 mg/d, in the treatment of 10 patients with the nephrotic syndrome and massive edema. The two drugs, which both act on the loop of Henle, were found to be equally effective. Patients with renal insufficiency responded poorly to both dr…

Five hundred and seventy-nine patients undergoing major laparotomy were randomly allocated to have midline or transverse incisions. Transverse incisions took longer to make and caused more bleeding but (in the absence of wound sepsis) no transverse wound burst and there were only 2 incisional hernias. In the midline gr…

A double blind study testing the effect of long-acting zinc-protamine-glucagon (7.5 mg every 12 hours for 4--5 days) was carried out in acute pancreatitis. There were 32 patients in ZP-glucagon- and 39 patients in the placebo group. The results show that glucagon had a slightly favourable effect on the general clinical…

The authors report their experience with graded-pressure elastic hose (TED Stockings) for the prevention of deep venous thrombosis of the lower limbs and pulmonary embolism in high-risk, bedridden postoperative patients. The trial was designed according to a closed sequential program and gave positive, statistically si…

A double-blind crossover study (12 weeks and 12 weeks) was performed to evaluate the effects of bromocriptine on the symptoms and serum prolactin levels of 14 women with spasmodic torticollis. While the serum prolactin level decreased in response to bromocriptine, no difference was found between the effects of placebo…

Randomized clinical trials are widely accepted as the standard for evaluation of therapeutic innovation in many fields of medicine. The three basic components of such trials (concurrent comparison, random allocation, and objective observation) are designed to control four forms of bias (chronology bias, susceptibility…

Ketotifen failed to protect against cat fur allergen induced asthma in a double blind placebo-controlled trial in ten asthmatic children. Disodium cromoglycate gave effective protection against the immediate and the late asthmatic reactions but there were no significant differences between the effects of ketotifen and…