4,999,347 papers found

BACKGROUND: Many published reviews do not meet the widely accepted PRISMA standards for systematic reviews and meta-analysis. Campbell Collaboration and Cochrane reviews are expected to meet even more rigorous standards, but their adherence to these standards is uneven. For example, a newly updated Campbell systematic…

BACKGROUND: Although community-level benefits of health system engagement (i.e., health service planning, delivery, and quality improvement, engaged research and evaluation, and collaborative advocacy) are well established, individual-level impacts on the health and well-being of community members are less explored, in…

BACKGROUND: Particulate matter (PM) is an important environmental risk factor for the initiation and exacerbation of respiratory disease. Various herbal medicines have exhibited a reduction in symptoms of respiratory diseases induced by PM in animal models. However, the types and characteristics of studies on herbal me…

INTRODUCTION: Sub-Saharan Africa is a subcontinent with a proud cultural richness and diversity, yet inexplicably also a region with severe health care challenges and inequity. To challenge this health equity gap and reduce the burden of disease, the patient's voice in monitoring and evaluation of health and health car…

BACKGROUND: The prevalence of type-2 diabetes mellitus (T2DM) has been increasing globally. Without proper management, T2DM can develop into serious complications and even death. Diet modification is one of the most effective tools in managing T2DM at the early stage, but it requires knowledge and compliance from the p…

BACKGROUND: Mesenchymal stem cells (MSCs) are multipotent cells that demonstrate therapeutic potential for the treatment of acute and chronic inflammatory-mediated conditions. Especially for acute conditions, it is critical to have a readily available freshly thawed (cryopreserved) MSC product for rapid administration.…

INTRODUCTION: The research literature addressing pre-exposure prophylaxis (PrEP) has increased considerably over the last decade. To better understand the research areas and explore research gaps, we will conduct a scoping review to map study topics and describe study characteristics and populations in publications foc…

BACKGROUND: Integrated reminders within clinical systems have become more prevalent due to the use of electronic health records and evidence demonstrating an increase in compliance within practice. Clinical reminders are assessed for effectiveness on an individual basis, rather than in combination with existing prompts…

Musculoskeletal injuries are a common presentation to the ED, with significant costs involved in the management of these injuries, variances in care within the ED and associated morbidity. A series of rapid review papers were completed to guide best practice for the assessment and management of common musculoskeletal i…

BACKGROUND: Pediatric brain tumors are the most common solid tumors in children. Advances in understanding the hallmarks of cancer biology and novel therapies have led to an increasing number of survivors of childhood brain tumors (SCBT). However, these survivors are at an increased risk of obesity and cardiometabolic…

BACKGROUND: The process of developing and updating an evidence gap map (EGM) is based on the principles of systematic reviews and requires extensive time and financial resources. Artificial intelligence (AI) tools, like prioritisation screening (PS), integrated into programmes such as EPPI-Reviewer (ER) and Copilot 365…

BACKGROUND: Compassion is widely studied as a prosocial motivator with recognized mental health benefits, yet the psychosocial effects of receiving compassion remain underexplored. Interpretive frameworks-whether religious or secular-may influence how individuals perceive and emotionally respond to compassionate acts.…

INTRODUCTION: Chronic low back pain (CLBP) is a leading global cause of disability and imposes significant social and economic burdens in rural sub-Saharan Africa (SSA). Mobile health (mHealth) technologies offer opportunities to improve CLBP management in areas with limited physiotherapy services. However, the effecti…

BACKGROUND: Dementia presents complex challenges for causal inference due to its multifactorial aetiology and slow, heterogeneous progression. Randomized controlled trials are often limited in their potential to fully address these challenges because of ethical and practical constraints. As the field evo…

INTRODUCTION: Fear of cancer recurrence (FCR) is one of the most prevalent psychological concerns among young adult cancer survivors. Despite its clinical relevance, little is known about how survivors overcome this fear and the role of healthcare professionals in that process. This protocol outlines a systematic revie…

INTRODUCTION: Male infertility, defined as the inability to impregnate a fertile female, arises from various factors, among which sperm motility plays a pivotal role in determining reproductive potential. Seminal plasma, a complex fluid comprising diverse proteins, serves to nourish and support sperm, thereby facilitat…

BACKGROUND: Fibromyalgia Syndrome (FMS) is characterised by widespread and persistent pain, intrusive fatigue and cognitive issues, affecting approximately 5.4% of the UK population. Non-pharmacological therapies and education are current management recommendations, but these approaches rely on patients having an activ…

BACKGROUND: Populations are ageing, making the quality of old age a crucial issue. Some adversity in old age, such as loss of loved one or loss of physical function, is often experienced, as is the need for recovery from such adversity. Resilience in later life has become an important topic and has accumulated much emp…

INTRODUCTION: Frailty is widely acknowledged as a multidimensional construct encompassing physical, psychological and social aspects. However, the lack of consensus in defining and operationalising psychological frailty challenges the holistic approach to frailty advocated by health professionals. Consequently, there i…

INTRODUCTION: Internationally, healthcare improvement remains a clinical and educational priority. Consensus in Europe, Canada and the USA to implement quality improvement (QI) education into preregistration nursing curricula ensures students become equipped with the skills and knowledge required to improve practice. N…