Some thoughts on the clinical evaluation of drugs.
Parkhouse J·Postgraduate medical journal
Abstract not available
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Parkhouse J·Postgraduate medical journal
Abstract not available
Hill A B·Annals of the rheumatic diseases
Abstract not available
Fujita T·Masui. The Japanese journal of anesthesiology
Abstract not available
Chassan J B·Psychosomatics
Abstract not available
Abramson H A·The Journal of asthma research
Abstract not available
Pellicer Adelina, Greisen Gorm, Benders Manon, +16 more·Neonatology
UNLABELLED: Near-infrared spectroscopy-derived regional tissue oxygen saturation of haemoglobin (rStO2) reflects venous oxygen saturation. If cerebral metabolism is stable, rStO2 can be used as an estimate of cerebral oxygen delivery. The SafeBoosC phase II randomised clinical trial hypothesises that the burden of hypo…
Fraser P M, Doll R, Langman M J, +2 more·Gut
The effects of a new carbenoxolone analogue (BX24), zinc sulphate, and vitamin A on the healing of gastric ulcer have been assessed in a multifactorial clinical trial conducted in out-patients treated for four weeks.Forty-eight patients completed the trial. Three groups of eight patients were given respectively 300, 60…
Colleoni M, Price K N, Castiglione-Gertsch M, +3 more·Lancet (London, England)
Combined chemotherapy for early breast cancer with cyclophosphamide, methotrexate, and fluorouracil has low associated mortality, but related deaths were seen among women aged 65 years or older in International Breast Cancer Study Group trials.
Zerbib M, Payan C·Urology
Abstract not available
Moyé L A, Davis B R, Hawkins C M·Statistics in medicine
Clinical trials often involve a variety of clinical and laboratory measures that are used as endpoints and sometimes two of these measures are combined in one endpoint. When the individual components of such a combined endpoint are 'time to event' measurements, the analysis is straightforward if each of the components…
Khodzhaeva N I·Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952)
The results of the treatment of three groups of patients with chronic alcoholism are compared. Group I (n = 26) received essential combined with hemoperfusion, group II (n = 18) placebo combined with hemoperfusion and group III (n = 20) was on teturam. It has been established that as compared with other treatment measu…
Topol E J·Cardiology clinics
The past 5 years have witnessed an explosion in the amount of published clinical trial data for the use of intravenous thrombolytic therapy for acute myocardial infarction. This article reviews the properties of the various agents, the experiences of each in prospective, randomized clinical trials, and the future direc…
Ferrari M, Olivieri M, De Gasperi M, +1 more·Annals of allergy
The protective effect of nifedipine and diltiazem on methacholine-induced bronchoconstriction was studied in 12 allergic asthmatic patients. Nifedipine significantly but weakly attenuated airway reactivity to methacholine, whereas no protective effect was shown by diltiazem. We conclude that the two calcium antagonists…
Alton E W, Johnson M, Turner-Warwick M·Respiratory medicine
Seven patients with fibrosing alveolitis who failed to respond to prednisolone and cyclophosphamide and were deteriorating, were treated with cyclosporin A. An initial favourable response was seen but was not maintained. When compared to a control population, matched for the extremely severe disease present in the trea…
Watson R·Journal of advanced nursing
An investigation was carried out on six hospitalized elderly male urinary incontinent patients for 21 days to test three urinary sheath systems by means of a quasi-experimental trial, incorporating crossover. Observations were made, and recorded, of detachment or leakage in systems and of skin condition round the shaft…
Tanashkin S F, Starosel'skiĭ D V, Mazyrko E D, +2 more·Klinicheskaia meditsina
The effectiveness of intensification of diuresis by means of hypothiaside and furosemide has been studied during treatment of 135 patients with viral hepatitis A and B. Both these agents were found to posses the same effect which was manifested by lessening of the intoxication syndrome, total blood toxicity and convale…
Kristiansen B, Angermann P, Larsen T K·Archives of orthopaedic and trauma surgery
In order to compare 1 and 3 weeks of immobilization following proximal humeral fractures a prospective controlled trial was performed in 85 patients. Clinical follow-up according to the Neer assessment system was done after 1, 3, 6, 12, and 24 months. One week of immobilization resulted in a better total score due to l…
Suzuki M, Hirasawa Y, Hirashima K, +7 more·Contributions to nephrology
Abstract not available
Rennie J M, Lam P K·Archives of disease in childhood
Cerebral blood flow velocity and cardiac output were measured with ultrasound before and 30 minutes after the administration of ethamsylate in a double blind placebo controlled study of 19 very low birthweight infants. No differences were found before or after treatment in either group.
Biary N, Pimental P A, Langenberg P W·Neurology
We studied the effect of clonazepam in a double-blind trial on 12 parkinsonian patients with hypokinetic dysarthria. Speech samples were judged on 14 of the dimensions used in the Mayo Clinic dysarthria study. Of the 11 patients who completed the study, 10 showed improvement. The effective dosage of clonazepam was 0.25…