96,737 papers found

BACKGROUND: Postmenopausal women who use hormone-replacement therapy (HRT) containing oestrogen alone are at increased risk of endometrial cancer. To minimise this risk, many HRT users who have not had a hysterectomy use combined oestrogen-progestagen preparations or tibolone. Limited information is available on the in…

Classification of odontogenic tumours is an academic exercise that has developed over the last 150 years. It was not until 1971 when a 5-year collaborated effort, organized by the World Health Organization (WHO), resulted in the first consensus on taxonomy of odontogenic tumours. The appearance of this first authoritat…

Microneurosurgery is Professor Yaşargil's legacy. Its impact on patient outcomes, surgeons' abilities, the field of neurosurgery in particular, and the art of surgery in general is great, profound, and everlasting. Professor Yaşargil led a revolution that has transformed neurosurgery into the fine art we pr…

OBJECTIVE: To describe the pertinent clinical data, outcomes, and maternal and fetal complications of cephalic replacement for the management of shoulder dystocia. METHODS: A registry for the reporting of cases of cephalic replacement was established 5 years ago. Features of the registry cases were reviewed. RESULTS:…

The authors present their statistics for perinatal mortality from 1961 to 1975. In the last 5 years this mortality is less than 15 per 1000, in spite of an increase in the numbers of pathological pregnancies. Over and above progress in obstetrics and neonatology that has occurred, this result can be attributed in part…

OBJECTIVE: Graves' disease (GD) is the main cause of hyperthyroidism among adults. It is an autoimmune condition classically marked by the Merserburg Triad (goiter, thyrotoxicosis, and orbitopathy), but the change in presentation of GD over time has rarely been studied. To determine changes in the clinical presentation…

OBJECTIVES: We attempted to answer the following questions: Why has the body mass index (BMI) increased so dramatically in the last 35 years? Are some food groups or additives more responsible than others? METHODS: Data for per capita food production available for consumption after spoilage for different food groups a…

Cyclical intravenous bisphosphonate therapy is widely used to treat children with osteogenesis imperfecta (OI), but little is known about long-term treatment outcomes. We therefore reviewed 37 children with OI (OI type I, n = 1; OI type III, n = 14; and OI type IV, n = 22) who…

In the last two decades, several cases of delayed-onset malaria in migrants from endemic areas were reported. The decrease of acquired immunity over time, often enhanced by immune suppression, represents a possible underlying mechanism for recrudescence. Here we describe a case ofmalaria occurring five years after expo…

Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery, agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s, their popularity has grown exponentially. Moreover, more than 50% of all contributions on the topic have been published in the last 5 years. In…

Quercetin is a kind of typical flavonoid, mainly found in various vegetables, fruits and Chinese herbs that are consumed daily, with the functions of anti-oxidation, anti-tumor, prevention and treatment of cardiovascular and cerebrovascular diseases. Quercetin is a natural compound with defined anti-tumor activity. Due…

We highlight the development of nanocontainer-based active materials started in 2006 at the Max Planck Institute of Colloids and Interfaces under the supervision of Prof. Helmuth Möhwald. The active materials encapsulated in the nanocontainers with controlled shell permeability have been first applied for self-hea…

Over the last 5 years, new oral anticoagulant options, including dabigatran, rivaroxaban and apixaban, have become available. Prior to this, vitamin K antagonists were the sole oral anticoagulants, which have been in use for more than 60 years. These novel agents have been studied in a variety of patient populations, i…

Laparoscopic pyloromyotomy was first reported 20 years ago. This technique uses a small umbilical incision and 2 small upper abdominal incisions. During the last 5 years, this approach has become the preferred technique for many pediatric surgeons in the infant who needs a pyloromyotomy. Recently, with the advent of si…

A 36-year-old man was admitted to our hospital due to dyspnea and pneumonia. He had undergone left classical Blalock-Taussig shunt at 5 years old and right modified Blalock-Taussig shunt at 16 years old, because he was judged as no indication for any radical operation. Since the last surgery, he had stopped visiting ho…

Magnetic recording technology has come a long way, since the introduction of the first hard disk drives (HDD) in 1956. The areal density has grown by a factor of 200 million times and the HDD has stayed as a main candidate for mass storage of information. In order to maintain its lead over other competing technologies,…

The aim of this study was to know the incidence of tick-borne rickettsial disease in a Mediterranean area. The incidence in 5 years for 100,000 inhabitants was 1.7 for tick-borne-lymphadenopathy (TIBOLA) and 0.4 for Mediterranean spotted fever (MSF). MSH incidence during the last few years has been lower than expected;…

Alu elements are the most abundant repetitive elements in the human genome; they emerged 65 million years ago from a 5' to 3' fusion of the 7SL RNA gene and amplified throughout the human genome by retrotransposition to reach the present number of more than one million copies. Over the last years, several lines of evid…

The ideal management of colloid cysts is controversial. Treatment options include shunting procedures, stereotactic cyst aspiration, open craniotomy for microsurgical removal, and endoscopic removal. Although recent literature would suggest endoscopic removal is a reasonable approach, issues of safety and efficacy have…

This report traces the evolution of surveillance programmes for influenza in the United Kingdom and countries of western Europe since the World Health Organisation (WHO) resolution to establish an international influenza reference centre in 1947. The introduction of clinical surveillance schemes in the late 1960s and t…