1,546,937 papers found

Open studies with nomifensine the placebo, and double-blind controlled comparisons of nomifensine with placebo, imipramine, amitriptyline, nortriptyline... have been carried out in various parts of the world. Daily dosage varied (50-225 mg), lenght of treatment also (226 weeks). These trials showed considerable effecti…

In a prospective study aimed at the cure of tinnitus due to blast injury, oral treatment of 172 patients with the mono-substances Betahistine, Pentoxifyllin and Xantinol-nicotinate were compared with those of control patients who received no medications. Patients treated with Pentoxifyllin and Xantinol-nicotinate impro…

The effects of whole coffee and de-caffeinated coffee on hyperactive children were compared, using a double-blind crossover design. Reactions were assessed by tests of concentration, digit recall, visuo-motor co-ordination, and parents' and teachers' rating scales. Whole coffee was associated with a significant improve…

Eight healthy volunteers received single doses of either mianserin 10 mg, mianserin 20 mg, amitriptyline 25 mg or placebo. Critical flicker frequency, reaction time, digit substitution and addition times were tested up to six hours afterwards. Mianserin 20 mg and amitriptyline 25 mg significantly prolonged reaction tim…

In a preliminary double-blind, placebo controlled, crossover study, 10 out of 16 patients (62.5%) had remissions in acute symptoms of food allergy with oral cromolyn therapy. The effective dosage for each patient had to be sought individually. No serious side effects were encountered.

A double-blind, group comparative trial of 2% aqueous solution of sodium cromoglycate in seasonal allergic rhinitis (hay fever) is reported. All twenty-five patients in the active group found the treatment a success whereas fourteen out of nineteen in the placebo group regarded this as a failure. The method of applicat…

The effect of cholestyramine in post-vagotomy diarrhoea has been assessed under double-blind conditions. Cholestyramine produced a significant improvement in frequency, urgency, and consistency of stool as well as episodic diarrhoea. Faecal bile acid excretion was significantly higher in the post-vagotomy group when co…

A comparison is made between oral ornidazole in a single 1-5 g dose and tinidazole given in a 2 g dose using a double-blind technique. All the 45 women with Trichomonas vaginalis infection who were treated with ornidazole were cured. In the tinidazole-treated group 41 out of 43 women had negative cultures after treatme…

The effects of bromocriptine and levodopa were compared in a blind trial in 18 patients with Parkinson's disease. Optimal doses of the two drugs were given in identical capsules: there was no significant difference between the therapeutic effects. There were wide individual differences in response to the two drugs. Sid…

A 5% solution of metaproterenol, 10 whiffs (1.5 mg) q.i.d., was administered from a hand bulb nebulizer to 28 asthmatics for 60 days. Spirometry in double-blind, crossover tests against an 0.5% isoproterenol solution on days 0-1 and 59-60 and global evaluations of response showed that metaproterenol was more effective…

Tibicorten, a new fluorine-substituted corticosteroid for topical application, was compared with betamethasone valerate in a double-blind investigation with left-right examinations. There appeared to be no significant difference between the results obtained with each substance in the treatment of patients with acute or…

Preoperative hair removal by a depilatory cream was compared with routine shaving. Although the incidence of wound infection was similar in both groups, cream depilation was found to be better. It was effective, atraumatic, non-toxic, and could be self-administered. Furthermore, it could be used safely on granulating w…

Fifty-four healthy patients and 21 patients with chronic renal disease received either suxamethonium 100 mg or suxethonium 150 mg for neuromuscular blockade during endotracheal intubation. A significant increase in plasma potassium concentration was observed following the administration of suxamethonium. No increase oc…

The effect of transfer factor prepared from relatives of patients with multiple sclerosis (M.S.) and from unrelated donors on the clinical course of M.S. has been studied in fifteen male and fifteen female patients. Some patients were given transfer factor and some placebo (physiological saline). Results of three indep…

A double blind trial of bromocriptine in the treatment of 14 patients with the symptoms of benign prostatic hypertrophy is reported. 5 patients did not complete the trial mainly because of side-effects due to an overdosage of bromocriptine. In the remaining 9 patients there was symptomatic improvement in 6, with object…

Twenty patients with coronary heart disease subjected to exercise testing presented ventricular arrhythmias. In a "double blind" design, oral disopyramide was administered during 7 days, after which the test was repeated. In 16 patients disopyramide prevented the appearance of arrhythmia or decreased their severity. Ba…

Two minor tranquilizers, diazepam and lorazepam were significantly better than a placebo preparation in relieving symptoms of functional gastrointestinal distress in 28 patients who took part in a double-blind cross-over trial. The beneficial therapeutic effect may be group- rather than preparation-specific. Both agent…

Random tests made in school children of the Ludwigsburg district showed that after 3 years of uncontrolled use, the number of new DMF surfaces is smaller in children using Na2PO3F toothpaste and regularly cleaning their teeth than in the corresponding placebo groups. The caries-inhibiting effect was statistically signi…

The influence of dipropylacetate (D.P.A.) on behaviour was studied in 20 patients using a double blind cross over trial. 5 patients were rated as improved on D.P.A., 6 on placebo, 3 as deteriorated on D.P.A., 3 on placebo, 12 as unchanged on D.P.A. and 11 on placebo. This study gives us no reason to believe that D.P.A.…