1,557,507 papers found

The effectiveness of intensification of diuresis by means of hypothiaside and furosemide has been studied during treatment of 135 patients with viral hepatitis A and B. Both these agents were found to posses the same effect which was manifested by lessening of the intoxication syndrome, total blood toxicity and convale…

In order to compare 1 and 3 weeks of immobilization following proximal humeral fractures a prospective controlled trial was performed in 85 patients. Clinical follow-up according to the Neer assessment system was done after 1, 3, 6, 12, and 24 months. One week of immobilization resulted in a better total score due to l…

Cerebral blood flow velocity and cardiac output were measured with ultrasound before and 30 minutes after the administration of ethamsylate in a double blind placebo controlled study of 19 very low birthweight infants. No differences were found before or after treatment in either group.

We studied the effect of clonazepam in a double-blind trial on 12 parkinsonian patients with hypokinetic dysarthria. Speech samples were judged on 14 of the dimensions used in the Mayo Clinic dysarthria study. Of the 11 patients who completed the study, 10 showed improvement. The effective dosage of clonazepam was 0.25…

The efficiency of various combinations of antiarrhythmic agents (quinidine, etmozin, disopyramide, mexitil, and allapinine) was assessed in 24 cases of frequent ventricular and supraventricular extrasystoles, where treatment with one of the above listed drugs had been ineffective. Combined use of the drugs produced ant…

Humphrey automated threshold perimetry (Program 30-2) was performed on 42 eyes of 25 patients with glaucoma to determine both the sensitivity and specificity of automated perimetry in detecting glaucomatous visual field defects. Automated perimetry sensitivity was 90.38%, while automated perimetry specificity was 91%.…

Whether or not prednisolone (or prednisone) should be used to treat alcoholic hepatitis remains controversial. This new controlled study performed on 45 patients with steatosis, fibrosis or cirrhosis of the liver suggests that prednisolone is not effective: after a 3-month follow-up clinical course, biochemical alterat…

The effects of physostigmine on test performance of a patient with multiple cognitive deficits were observed in a double-blind, placebo-controlled study. Scores on tests of learning and memory and tests of visuo-spatial and constructional ability were both improved by physostigmine, while lecithin improved scores only…

Post-tonsillectomy analgesia from ibuprofen, aspirin and placebo is compared in a double-blind study. The results are reported showing ibuprofen to have greater therapeutic benefit than placebo whereas aspirin did not. Methods of providing pain relief after tonsillectomy and the relative clinical merits of ibuprofen an…

This double-blind parallel group study evaluated ketotifen 1 mg bid versus placebo in the treatment of 30 adult seasonally allergic asthmatics during the course of the spring pollen season. Those individuals on placebo had a fall in FEV1 through the pollen season, those on Ketotifen generally did not, and some individu…

The prostaglandin synthesis inhibitor diclofenac sodium has been compared with a placebo in the treatment of primary nocturnal enuresis in a double-blind crossover trial. Twenty patients were entered: 14 female, six male; age range 6-17 years. The results showed that diclofenac sodium was significantly more effective t…

The long term administration of a methyl donor (S-adenosylmethionine, SAM) relieves pain in migraine sufferers. The benefit arises gradually and long-term treatment is required for therapeutic effectiveness. Since SAM is an almost ubiquitous methyl donor in many biological systems, an explanation of this peculiar thera…

The two-year follow-up results are reported of a trial of social intervention in families of schizophrenic patients in high social contact with high-expressed emotion (EE) relatives. For those patients who remained on antipsychotic medication throughout the two years, the social intervention significantly reduced the r…

Eight severely retarded residents took part in a double blind, placebo controlled trial of pimozide. The drug did not alter behavioural adjustment as assessed by behaviour observations. However, ratings on a standardised checklist of aberrant behaviour showed significant drug-induced improvements on two dimensions (Irr…

Combined bronchodilator effects of the beta 2-agonist pirbuterol and theophylline were studied in anaesthetized rats and in asthmatic outpatients. In rats, pirbuterol was more effective than aminophylline in reducing methacholine-induced bronchoconstriction without counteracting associated hypotension. In combination t…

Over 40 published and unpublished articles on double-blind controlled clinical trials with the local application of benzydamine as an antiinflammatory drug were reviewed with special reference to the randomization of patients, the description of the disease entity, the clinical trial and its statistical analysis. It wa…