Sample size calculation using Markov chains for a one-arm study of heroin administration routes.
Grischott Thomas, Valeri Fabio, Falcato Luis·Journal of biopharmaceutical statistics
Sample size calculations for trials with time-to-event outcomes are usually based on the assumption that an event - prototypically death in survival analysis - occurs only once per sample unit. However, events like changes in disease status or switches between treatment modalities may repeat over time. In trials with s…