44,621 papers found

BACKGROUND: The peer review process is a cornerstone of biomedical research. We aimed to evaluate the impact of interventions to improve the quality of peer review for biomedical publications. METHODS: We performed a systematic review and meta-analysis. We searched CENTRAL, MEDLINE (PubMed), Embase, Cochrane Database…

BACKGROUND AND PURPOSE: Neuromuscular electric stimulation (NMES) has been used to reduce spasticity and improve range of motion in patients with stroke. However, contradictory results have been reported by clinical trials. A systematic review of randomized clinical trials was conducted to assess the effect of treatmen…

OBJECTIVE:   Information regarding the relative risks of developing knee osteoarthritis (OA) as a result of sport participation is critical for shaping public health messages and for informing knee-OA prevention strategies. The purpose of this systematic review was to investigate the association between particip…

BACKGROUND: Each year, 287,000 women die from complications related to pregnancy or childbirth, and 3.8 million newborns die before reaching 28 days of life. The near totality (99%) of maternal and neonatal deaths occurs in low- and middle-income countries (LMICs). Utilization of essential obstetric care services inclu…

OBJECTIVES: This evaluation investigates characteristics of health economics evaluations in CAM. Particular emphasis is paid to differences regarding continental origin and time of publication of investigations. METHODS: Database searches to identify potential studies were carried out in Medline (via Pubmed), the Coch…

OBJECTIVES: The advent of biological therapies for inflammatory bowel disease (IBD) began in 1998 with the approval of infliximab for the treatment of refractory (to conventional agents) Crohn's disease (CD). Since then, the indications for anti-tumor necrosis factor-α (anti-TNFα) therapy have increased to…

OBJECTIVE: To summarise the extent to which narrative text fields in administrative health data are used to gather information about the event resulting in presentation to a health care provider for treatment of an injury, and to highlight best practise approaches to conducting narrative text interrogation for injury s…

BACKGROUND: Anastomotic leak (AL) is a major complication in colorectal surgery, significantly contributing to perioperative morbidity and mortality. Among strategies to prevent AL, Indocyanine Green Fluorescence Angiography (ICG-FA) has emerged as a promising method for assessing bowel perfusion intraoperatively. This…

BACKGROUND AND HYPOTHESIS: Parathyroid carcinoma (PTTC) is a rare malignant endocrine tumor seen in up to 1-2% of all cases of primary hyperparathyroidism. However, incidence of parathyroid carcinoma in renal hyperparathyroidism is a rare phenomenon. We aimed to evaluate the outcomes of PTTC in renal hyperparathyroidis…

BACKGROUND: The role of vitamin D supplementation in improving cognition and slowing the incidence of minor and major neurocognitive disorders is a matter of debate. To our knowledge, no systematic review of randomized controlled trials (RCTs) has examined this question in adults. OBJECTIVES: The purpose of this syste…

OBJECTIVE: Insomnia causes daytime impairment and reduced quality of life. We evaluated the comparative efficacy and safety of Traditional Chinese Medicine (TCM) treatment strategies for insomnia. METHODS: Nine databases (PubMed, Embase, Web of Science, Cochrane CENTRAL, ClinicalTrials.gov, CNKI, Wanfang, VIP, SinoMed…

BACKGROUND/OBJECTIVES: Overweight and obesity in children and adolescents is a global health issue with increasing prevalence. The Mediterranean diet (Med diet) is an extensively studied dietary pattern with benefits on various health conditions such as cardiovascular disease, diabetes mellitus and obesity in adult pop…

BACKGROUND: Hematological malignancies including leukemia, lymphoma, and myelodysplastic syndromes, are characterized by clonal proliferation of abnormal blood or bone marrow cells. Early and accurate detection is essential for improving treatment outcomes and survival. Automated hematology analyzers generate abnormal…

BACKGROUND: Asthma is a heterogeneous inflammatory disease that can cause substantial morbidity, reduced quality of life, and socioeconomic burden when uncontrolled. Biologic therapies have become central to the management of moderate-to-severe asthma by targeting specific inflammatory pathways. METHODS: This overview…

BACKGROUND: This systematic review aims to evaluate the efficacy, safety, and tolerability of oral tapentadol in the management of cancer-related pain in adults. It updates the 2015 Cochrane review on the same topic by including newer trials up to March 2024. METHODS: A systematic search of Medline (via PubMed), the C…

BACKGROUND: Ranges of corneal tissue removal and residual stroma are the most essential safety consideration for corneal refractive procedures and directly determine the eligibility of candidates who may benefit from surgery. Small-incision lenticule extraction (SMILE), a laser procedure, has been performed for more th…

Aerobic (AT) and resistance training (RT) are well established as effective strategies for lowering blood pressure (BP) in patients with hypertension; however, evidence on the impact of combined training (CT; AT and RT) on BP remains limited. We therefore conducted a meta-analysis of randomized controlled trials (RCTs)…

BACKGROUND: Children with normal Body Mass Index (BMI) may still exhibit adverse metabolic profile-termed as the metabolically obese normal weight (MONW) phenotype, placing them at increased risk of long-term cardiometabolic complications. OBJECTIVE: To systematically synthesise the evidence of the MONW phenotype in c…

BACKGROUND: Clavipectoral fascial plane block (CPB) is a novel regional anesthesia technique for clavicle fracture operation that provides effective analgesia while minimizing phrenic nerve involvement. Traditional approaches, including interscalene brachial plexus block (ISBPB) and superficial cervical plexus block (S…

INTRODUCTION: In the field of medicine, there has been a growing understanding of the impact of social and economic inequities on patients' health outcomes. Social medicine was established with the intention of addressing these social and economic drivers of health when caring for patients. Physicians who practise soci…