Searching PubMed for “Clinical Trial” and checking full-text availability…
for “Clinical Trial” · Showing 9,781–9,800 · 4003 ms
Halsted C, Lepow M L, Balassanian N, +2 more·American journal of diseases of children (1960)
Abstract not available
Holden J M, Itil T, Simeon J, +1 more·The Journal of clinical pharmacology and the journal of new drugs
From a population of chronic schizophrenic patients receiving new psychotropic drug treatments, 48 were maintained on placebo medication for periods up to twenty weeks. Clinical pathological laboratory data were collected at the same intervals as in the drug-treated groups. While the range of laboratory findings was si…
Földi M, Obál F, Kahán A, +3 more·Acta paediatrica Academiae Scientiarum Hungaricae
Abstract not available
Haley E Clarke, Thompson John L P, Grotta James C, +13 more·Stroke
BACKGROUND AND PURPOSE: Intravenous alteplase (rtPA) remains the only approved treatment for acute ischemic stroke, but its use remains limited. In a previous pilot dose-escalation study, intravenous tenecteplase showed promise as a potentially safer alternative. Therefore, a Phase IIB clinical trial was begun to (1) c…
Naydeck B L, Sutton-Tyrrell K, Burek K, +1 more·Controlled clinical trials
Efficient communication is a challenge for the many operating components of a multicenter randomized clinical trial. Traditional management theory states that communications generally flow along a path established by a hierarchical organizational structure. A multicenter clinical trial does not fit traditional organiza…
Henderson W G, Fisher S G, Weber L, +2 more·Controlled clinical trials
This article describes a computer simulation methodology to calculate conditional power for comparing two arbitrary survival curves as an aid in deciding whether or not to extend a clinical trial. The method is a modification of that by Halpern and Brown, which computes unconditional power for comparing arbitrary survi…
Westaby D, Hayes P C, Gimson A E, +2 more·Hepatology (Baltimore, Md.)
In a prospective, randomized clinical trial, immediate injection sclerotherapy was compared with treatment by a combined infusion of vasopressin (0.4 unit per min) and nitroglycerin (40 to 400 micrograms per min) in 50 consecutive patients with 64 episodes of endoscopy-proven variceal hemorrhage. Control of bleeding wa…
Thomas A, Nagarajan M, Chandrasekaran V, +6 more·Indian journal of leprosy
A double blind controlled clinical trial to assess the role of anti-histamines as a supplement in the treatment of leprosy was conducted in multi-bacillary cases of leprosy. In all, 120 patients with lepromatous or borderline leprosy were randomly allocated to a regimen of clofazimine and dapsone for 12 months with or…
Harada K, Okamoto H, Fujioka Y, +7 more·Gan to kagaku ryoho. Cancer & chemotherapy
A total of 71 cases with primary brain tumors (44 cases) and metastatic brain tumors (30 cases) were entered into our clinical studies with MCNU and radiation therapy or MCNU alone. With regard to tumor reduction on CT scan, the response rates obtained for MCNU and radiation were 21.7% for malignant gliomas and 50.0% f…
Smith R C, Hartemink R J, Hollinshead J W, +1 more·The British journal of surgery
A randomized controlled prospective clinical trial has been undertaken to examine the efficacy of the technique of early postoperative feeding using a fine bore catheter jejunostomy. Fifty patients undergoing surgery for gastrointestinal malignancy were randomly allocated into treatment and control groups. A low residu…
The American review of respiratory disease
Two 6-month daily regimens of chemotherapy for smear-positive pulmonary tuberculosis were compared in Tanzania. Both had the same initial 2-month intensive phase of streptomycin, isoniazid, rifampicin, and pyrazinamide, and the continuation phase was either thiacetazone plus isoniazid or isoniazid alone. All patients w…
Dowell R C, Martin L F, Clark G M, +1 more·The Annals of otology, rhinology, and laryngology
Speech discrimination testing was carried out under clinical trial conditions for eight profoundly postlingually deaf adults to assess the efficacy of a newly developed 22-channel cochlear prosthesis and speech processor. Three months postoperatively, these patients showed significantly better results with the cochlear…
Archives of ophthalmology (Chicago, Ill. : 1960)
The Idiopathic Neovascularization Study is a multicenter controlled clinical trial designed to determine whether argon laser photocoagulation is useful in preventing severe visual loss in eyes with a choroidal neovascular membrane (NVM) and no other clinically significant eye disease. Patients with an NVM 200 to 2,500…
Ribeiro G, Palmer M K·British medical journal (Clinical research ed.)
A large controlled clinical trial with the admission of 1005 patients was carried out using tamoxifen as adjuvant treatment for women with operable carcinoma of the breast. Results were analysed for the first 906 evaluable patients randomised up to December 1981. After mastectomy premenopausal women were randomised to…
Shoemaker W C, Appel P L, Waxman K, +2 more·Critical care medicine
The hypothesis was tested that the median values of survivors of life-threatening postoperative conditions, rather than the norms of unstressed healthy volunteers, are the appropriate therapeutic goals for critically ill postoperative patients. The authors studied prospectively a series of 100 consecutive critically il…
Langlands A O, Prescott R J, Hamilton T·The British journal of surgery
The results of a randomized controlled clinical trial in the management of operable breast cancer are given. Between 1964 and 1971 498 women, aged 35-69 years, were treated within the trial protocol. Those under 60 years of age on entry underwent ovarian ablation, usually by surgery, and were allocated randomly to trea…
Polk B F, Tager I B, Shapiro M, +3 more·Lancet (London, England)
To determine the efficacy of perioperative cefazolin in preventing pelvic and wound infections after elective non-radical hysterectomy, a randomised, placebo-controlled, double-blind clinical trial was done. Among 86 patients undergoing vaginal hysterectomy, those who received three perioperative 1 g doses of cefazolin…
Polderman J, Colon M·The Journal of international medical research
Sixteen general practitioners conducted a multicentre double-blind clinical trial to compare oxamethacin (100 mg t.i.d.) with indomethacin (50 mg t.i.d.) for a maximum duration of 2 weeks. Each drug was administered to 339 patients suffering from various pathological conditions requiring a non-steroidal anti-inflammato…
Tanaka N, Tsuchiya R, Ishii K·Advances in experimental medicine and biology
In order to evaluate the efficacy and safety of FOY injectable ([ethyl-4-(6-guanidinohexanoyloxy) benzoate] methane sulfonate) on acute pancreatitis, a comparative clinical study was carried out using Trasylol as the control at 38 hospitals in Japan. Favourable results were obtained in 60 (71%) out of 84 patients in th…
Grof P, Saxena B, Daigle L, +1 more·British journal of clinical pharmacology
1. Nomifensine (8-amino-2-methyl-4-phenyl-1,2,3,4,-tetrahydroisoquinoline) is a new antidepressant which displays an interesting pharmacological profile and acts as a potent dopaminergic agonist. 2. In a double-blind clinical trialnomifensine was compared with a standard and widely tested antidepressant amitriptyline.…