391,885 papers found

Storage and directed transfer of information is the key requirement for the development of life. Yet any information stored on our genes is useless without its correct interpretation. The genetic code defines the rule set to decode this information. Aminoacyl-tRNA synthetases are at the heart of this process. We extens…

The Null Hypothesis Significance Testing (NHST) paradigm is increasingly criticized. Estimation approaches such as point estimates and confidence intervals, while having limitations, provide better descriptions of results than P-values and statements about significance levels. Their use is supported by many statisticia…

Paratuberculosis is a worldwide infectious disease caused by Mycobacterium avium ssp. paratuberculosis (MAP). Various ruminant species can be affected by the disease, and the diagnosis of the disease is challenging in the absence of a gold standard test. The aim of this systematic review protocol is to determine the ac…

Recently a number of acupuncture clinical trial projects mainly conducted by conventional scientists have generated many negative results. A large meta-analysis of patient-level acupuncture data for the treatment of chronic pain conditions have demonstrated that the effects of verum acupuncture on pain improvement have…

MOTIVATION: Identification of single nucleotide polymorphisms that are associated with a phenotype in more than one study is of great scientific interest in the genome-wide association studies (GWAS) research. The empirical Bayes approach for discovering whether results have been replicated across studies was shown to…

In non-inferiority clinical trials, a test treatment is compared to an active-control rather than to placebo. Such designs are considered when placebo is unethical or not feasible. The critical question is whether the test treatment would have been superior to placebo, had placebo been used in the non-inferiority trial…

A meta-analysis of a continuous outcome measure may involve missing standard errors. This is not a problem depending on assumptions made about the population standard deviation. Multiple imputation can be used to impute missing values while allowing for uncertainty in the imputation. Markov chain Monte Carlo simulation…

Meta-analyses have followed some of the most important advances in the treatment of early-stage Hodgkin lymphoma (HL). In this review, details on all meta-analyses of patients with early-stage HL are discussed. In 1990, the first meta-analysis addressing patients with early-stage HL compared radiotherapy alone to combi…

UNLABELLED: Founded upon the database of 570 public signatures, ICPS is a web-based application to obtain biomarker profiles among 11 common cancers by integrating genomic alterations with transcription signatures on the basis of a previously developed integrative pipeline. ICPS supports both public data and user's in-…

A systematic review provides the best summary of evidence for clinical decision-making in nephrology by summarizing all the primary studies that evaluate a specific clinical question. By using rigorous and pre-specified methods, conclusions about the overall effect of an intervention can be more reliable, precise and c…

The benefits of statins in patients with stable coronary syndrome is indisputable, however their early use in acute coronary syndrome (ACS) is under debate. There are few existing clinical trials and meta-analysis results on this and their results provide little clarification. However, most of the registries have found…

Currently, the challenge is to analyze and synthesize as much information as possible in order to make quick, correct decisions. Systematic reviews and meta-analysis have quickly arisen in the health field because they allow researchers to congregate studies of similar characteristics to generate estimators that descri…

The authors reviewed studies on college students' physical activity (PA) behaviors and found that previous research on this topic focused on describing college students' PA patterns and their determinants. Researchers reported that about 40% to 50% of college students are physically inactive. More important, health and…

The present article reviews recent studies of 'healthy aging' with and without cardiovascular risk factors and accompanying white matter changes. Specifically, the relationship between white matter hyperintensities (WMH) and various cognitive functions, in particular executive functions (EF), was subjected to meta-anal…

Coronary artery disease remains a common problem in industrialized countries. Percutaneous coronary interventions are usually performed utilizing the femoral approach. Arterial puncture-closing devices have been developed in hope to avoid manual compression and shortening the period of rest. In a recent meta-analysis i…

A recent meta-analysis of all randomised trials assessing the efficacy and safety of glycoprotein IIb/IIIa agents with acute coronary syndromes showed that there was a significant interaction with sex. Explaining this difference requires an analysis of whether it has any pathophysiological basis, whether antithrombotic…

Randomised controlled trials have shown that screening may significantly reduce mortality in colorectal cancer. In the present evaluation it is shown that the reported reduction of 15 per cent, or higher, is given in relative figures. With absolute figures the reduction is only 0.15 per cent or lower. The number of ind…

The Cochrane collaboration has performed a meta-analysis of all studies found on the prevention of ankle ligament injuries, frequent in sports like soccer, European handball and basketball. Interventions include the use of modified footwear and associated supports, training programmes and health education. Five randomi…

Evidence of the benefit of exercise for patients with musculoskeletal problems was examined by analysing meta-analyses and systematic reviews. The literature search was confined to studies where pain and/or function was used as the outcome measure. Twenty-three meta-analyses/systematic reviews were covered, and the met…