44,621 papers found

BACKGROUND: Sepsis coincides with altered gene expression in different tissues. Accumulating evidence has suggested that microRNAs, long non-coding RNAs, and circular RNAs are important molecules involved in the crosstalk with various pathways pertinent to innate immunity, mitochondrial functions, and apoptosis. METHO…

INTRODUCTION: Even considering the advance of the medical treatment in the last 20 years with new and more effective drugs, the outcomes are still disappointing as the control of obesity and type 2 Diabetes Mellitus (T2DM) with a large number of patients under the medical treatment still not reaching the desired outcom…

BACKGROUND AND OBJECTIVES: The goal of this meta-analysis study was to assess the effects of fentanyl on emergence agitation (EA) under sevoflurane anesthesia in children. SUBJECTS AND METHODS: We searched electronic databases (PubMed, Embase, Web of Science and the Cochrane Central Register of Controlled Trials) for…

OBJECTIVE: This meta-analysis was conducted to evaluate the efficacy of acupuncture on cognitive impairment (function) after a stroke. DESIGN: Randomized controlled trials (RCTs) comparing acupuncture with no acupuncture in addition to medicine or rehabilitation were identified from databases (PubMed, Cochrane Central…

PURPOSE OF REVIEW: Advances in radiation therapy techniques that allow for better normal tissue sparing have made reirradiation (reRT) a more viable option for managing locoregional recurrences in various cancers. However, severe toxicity and a high risk of second recurrence persist, emphasizing the need for improved p…

BACKGROUND: Sporadic amyotrophic lateral sclerosis (sALS) is a severe neurodegenerative disease characterized by continuous diminution of motor neurons in the brain and spinal cord. Earlier studies indicated that the DPP6 gene variant has a role in the development of sALS. This meta-analysis was designed to uncover the…

PURPOSE: The recent trend of Internet-based digital health interventions has driven researchers to implement them to promote physical activity (PA) and improve patients' health outcomes. This systematic review and meta-analysis aim to evaluate the effects of Internet-based digital health interventions on PA and quality…

BACKGROUND: Opioids are commonly used for general anesthesia, but reflex cough can occur after an intravenous injection. We have performed a meta-analysis of randomized controlled trials (RCTs) that evaluated the effectiveness and safety of prophylactic lidocaine administered intravenously (IV) on opioid-induced cough…

BACKGROUND: As larger-sized superficial esophageal neoplasms became candidates for endoscopic submucosal dissection (ESD), post-ESD esophageal stricture has inevitably developed into a significant complication during long-term follow-up. METHOD: The PubMed, Cochrane Central Register of Controlled Trials, MEDLINE, EMBA…

AIM: To examine the effects of Extended Reality (XR) case-based learning in interprofessional education on pre-licensure health profession students' learning outcomes and explore students' experiences with the technology. BACKGROUND: Interprofessional education is essential for preparing a collaborative practice-ready…

INTRODUCTION: Ventilator-induced diaphragmatic dysfunction is increasingly recognised as an important complication of prolonged mechanical ventilation (MV) and a major contributor to difficult weaning and extubation failure. Although bedside diaphragmatic ultrasound has emerged as a useful tool for assessing diaphragm…

Adult patients supported with extracorporeal membrane oxygenation (ECMO) frequently require invasive diagnostic, therapeutic, surgical, or bedside procedures during ongoing extracorporeal support. These procedures are clinically challenging because ECMO-related anticoagulation, platelet dysfunction, acquired coagulopat…

BACKGROUND: Therapeutic drug monitoring (TDM) may help optimize beta-lactam antibiotic dosing in patients with deep-seated infections. However, its impact on clinical outcomes remains unclear. OBJECTIVE: The objective of this review was to evaluate the existing evidence on the role of TDM and pharmacokinetic/pharmacod…

Concurrent chemoradiotherapy (CRT) remains a standard treatment for locally advanced esophageal cancer, yet the approach poses significant cardiotoxic risks due to the proximity of the esophagus to cardiac structures. This systematic review synthesized recent evidence from observational st…

CONTEXT: Lifestyle interventions focused on dietary and physical activity strategies are the cornerstone of type 2 diabetes (T2D) prevention and management. While their clinical benefits are well established, less is known about their effects on reversing gut dysbiosis. OBJECTIVE: To investigate the role of gut microb…

BACKGROUND: Acupoint catgut embedding (ACE) is a therapeutic method for pain management that involves inserting a thread or catgut into the body with anti-hyperalgesic effect. This study aims to systematically review and comprehensively compare the effectiveness of ACE with that of each comparator in the treatment of k…

BACKGROUND: Rhus coriaria L. (Anacardiaceae), known as Sumac, is a commonly used spice, which is rich in various classes of phytochemicals including flavonoids, tannins, polyphenolic compounds, organic acids, and may be beneficial for cardiovascular disease risk factors. This comprehensive systematic revi…

BACKGROUND: Digital interventions can provide cost-effective, quality health care for patients with chronic conditions. Patients with chronic conditions often are burdened by a substantial load of adhering to a treatment regimen and suffer from impacts on their function and well-being. This treatment burden has consequ…

Erectile dysfunction (ED) is a common and distressing complication following radical prostatectomy, significantly affecting patients' quality of life. Low-intensity extracorporeal shock wave therapy (LI-ESWT) has emerged as a non-invasive modality aimed at enhancing erectile function through tissue regeneration and imp…

Potassium channels, particularly the sodium-activated Slo2 (Slack/KCNT1) channels, play a critical role in regulating neuronal excitability and protein synthesis. Emerging evidence suggests a strong association between Slo2 channel dysfunction and the development of intellectual disability (ID), including conditions li…