CRISPR-Cas9-mediated IncF plasmid curing in extraintestinal pathogenic.
Chen Liang, Peirano Gisele, Yen Kelly, +5 more·Microbiology spectrum
Understanding the role of IncF plasmids in the success of drug-resistant bacteria has far-reaching implications for tackling antibiotic resistance. The study's use of a novel CRISPR-Cas9-mediated plasmid-curing system provides a precision tool for dissecting the specific impact of IncF plasmids on ExPEC clones, especia…