391,885 papers found

When combining the results of independent studies it often happens that some studies are potentially aberrant either in quality or in actual values. Because aberrant studies are often at the extremes, we may wish to trim some of the largest and smallest effects. In such a case the use of p-values may well serve as a di…

The "evidence" in EBM must be of high quality in order to be useful, but this is not always the case. Even the "gold standard" of evidence-based medicine, the randomised clinical trial, is bedevilled by low inclusion rates and potentially important recruitment biases. "Real world" trials often do not give the same resu…

OBJECTIVE: To explain the concepts and application of Bayesian modelling and how it can be applied to the analysis of dental research data. BASIC DESIGN: Methodological in nature, this article introduces Bayesian modelling through hypothetical dental examples. SETTING: The synthesis of RCT results with previous evide…

The effectiveness of classroom reality orientation (RO) in dementia was evaluated by conducting a systematic literature review. This yielded 43 studies, of which 6 were randomized controlled trials meeting the inclusion criteria (containing 125 subjects.) Results were subjected to meta-analysis. Effects on cognition an…

Meta-analysis facilitates the transfer of knowledge from nurse researchers to clinicians. In this article, the benefits and criticisms of meta-analysis for nursing are identified along with the specific problems a meta-analyst may encounter in conducting a quantitative analysis and synthesis of the literature. Problems…

We review recent research on the prevalence, causes, and effects of diagnostic comorbidity among the most common groups of child and adolescent psychiatric disorders; anxiety disorders, depressive disorders, attention deficit hyperactivity disorders, oppositional defiant and conduct disorders, and substance abuse. A me…

We present a methodology for combining trials some of which report continuous outcome measures and others binary outcomes created by a dichotomy of the continuous measurement. This was motivated by a series of controlled clinical trials investigating the effect of prophylactic use of oxytocics on postpartum blood loss…

The aim of this study was to develop a quality of study tool rate the methodological quality of individual primary randomized controlled trials (RCTs) to be included in a meta-analysis. A Delphi-technique using several rounds of questions to seek consensus, among trialists, on criteria important in a RCT was used. Eigh…

IMPORTANCE OF GUIDELINES: Guidelines to medical practice are of vital importance because of the fast and uncontrolled introduction of new technologies, increasing amounts of information, including contradictory results, high levels of inappropriate care and increased financial pressure. Thus guidelines can help solve c…

Twenty-four normal right-handed male subjects classified hierarchical visual stimuli (small letters arranged to form larger letters), which were presented separately to each cerebral hemisphere. Previous studies using similar paradigms have yielded mixed evidence for the specialization of local, analytic processing in…

This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the benefits and harms of endoscopic and surgical interventions for idiopathic achalasia, including pneumatic dilation, laparoscopic Heller myotomy (LHM), and per-oral endoscopic myotomy (POEM), using pairwise meta-analyse…

INTRODUCTION: Unplanned hospital readmission (UHR) following surgical procedures reflects patient outcomes. While adult readmission studies are abundant, limited research exists in paediatric populations, especially in the context of neurosurgery. METHODS AND ANALYSIS: This protocol outlines a systematic review aimed…

Typical large-group institutions for abandoned children or orphans are known to be bad for the development of children, but what about small-group care? Rygaard (2020) presents SOS Children's Villages (SOSCV) as a natural and nondetrimental setting for abandoned children. In a random effects meta-analysis, we combined…

We read with great interest an article by Karanasos et al. titled "Impact of smoking status on disease severity and mortality of hospitalized patients with COVID-19 infection: a systematic review and meta-analysis".It is inferred that there is an adverse impact of smoking on disease severity and mortality of hospitaliz…

A recently published meta-analysis in this journal analyzed findings from studies comparing substrate use during exercise at the same relative intensity (i.e., % V̇Omax) in normoxic and hypoxic conditions. The primary conclusion was that hypoxia had no consistent effects on the contribution of carbohydrate oxidat…

There has been an increasing amount of information about the positive results of low-carbohydrate diet in the treatment of diabetes, pre-diabetes, metabolic syndrome and obesity in the form of randomized trials, their meta-analysis and case studies. Many of these indicate that low carbohydrate diets are safe, could sig…

Improved understanding of tick phylogeny has allowed testing of some biogeographical patterns. On the basis of both literature data and a meta-analysis of available sequence data, there is strong support for a Gondwanan origin of Ixodidae, and probably Ixodida. A particularly strong pattern is observed for the genus Am…

Data commons have emerged as the best current method for enabling data aggregation across multiple projects and multiple data sources. Good data harmonization techniques are critical to maintain quality of data within a data commons, as well as to allow future meta-analysis across different data commons. We present som…

We propose statistical methods to detect novel genetic variants using only genome-wide association studies (GWAS) summary data without access to raw genotype and phenotype data. With more and more summary data being posted for public access in the post GWAS era, the proposed methods are practically very useful to ident…