42,199 papers found

Pakistan's female healthcare force faces numerous challenges compared to their male counterparts that hinder their professional development. These systemic barriers contribute to mental health struggles and high attrition rates among women in the healthcare sector. This systematic review aims to identify and analyse th…

INTRODUCTION: Quality of life (QoL) is a central outcome in palliative care (PC), particularly in hospital settings, where patients often present with advanced illness, complex symptoms, and multidimensional needs. Accurate QoL assessment is essential to support patient-centered and family-centered decision-making; how…

BACKGROUND: Insomnia is highly prevalent in Armed Forces (AF) and veteran populations and undermines readiness and quality of life. While Cognitive Behavioural Therapy for Insomnia (CBT-I) is first-line, access is limited in military settings, and although digital CBT-I offers a scalable alternative, evidence in this p…

Hypoglycemia is a rare but potentially serious adverse effect of second-generation antipsychotics (SGAs). Most studies have focused on SGA-induced hyperglycemia and metabolic syndrome, while hypoglycemia in non-diabetic adults remains underreported. We describe a case of severe hypoglycemia following risperidone initia…

BACKGROUND: Preadmission metformin may lower mortality in diabetic sepsis patients, but evidence is conflicting, necessitating a systematic review and meta-analysis for confirmation. METHODS: We systematically searched MEDLINE (via PubMed), EMBASE, and Cochrane CENTRAL from inception to September 1, 2025, for cohort s…

BACKGROUND/OBJECTIVE: Aneurysmal subarachnoid hemorrhage (aSAH) is complicated by angiographic cerebral vasospasm and delayed cerebral ischemia (DCI), distinct entities with different reference standards and surveillance targets. We mapped the evidence on (1) diagnostic accuracy of vasospasm monitoring tools using digi…

BACKGROUND: Antibiotic lock therapy (ALT) delivers high-concentration antimicrobials into catheter lumens and has been proposed to prevent infections in hemodialysis (HD) patients. METHODS: We conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) and quasi-experimental studies comparing…

OBJECTIVES: This network meta-analysis (NMA) rigorously assessed the regenerative potential of autologous particulate dentin graft (ADG) in the context of alveolar ridge preservation (ARP), comparatively analyzing its performance against particulate xenogeneic (XG), allogeneic (ALG), alloplastic (APG) grafts, and blood…

INTRODUCTION: Acute musculoskeletal injuries are a common reason for primary care consultations. Nonsteroidal anti-inflammatory drugs (NSAIDs) are currently used in this context. Recent meta-analyses (M-A) showed a better benefit--risk profile for topical NSAIDs and no superiority of oral NSAIDs over paracetamol alone…

Family caregivers of brain tumor patients often experience severe psychological problems, with a high prevalence of mental health issues posing a growing challenge in clinical practice. However, the psychological burden borne by these caregivers remains underrecognized. This study aimed to systematically assess the psy…

Intravenous atropine is widely recommended as the first-line treatment for symptomatic bradycardia, but because the optimal initial dose remains uncertain, the aim of this scoping review was to examine the existing literature on the efficacy and safety of intravenous atropine at specific doses in adult patients with sy…

: Cerebral palsy (CP) is the most common cause of motor disability in childhood and is frequently associated with cognitive impairments that limit autonomy and participation. While motor function is a known predictor of functional outcomes, the specific contribution of cognitive domains within the International Classif…

INTRODUCTION: Emergency surgical services in the UK face rising pressures, and early laparoscopic cholecystectomy (ELC) is inconsistently implemented despite National Institute for Health and Care Excellence (NICE) and the World Society of Emergency Surgery (WSES) recommendations. Limited emergency theatre capacity and…

Children with Down syndrome (DS) present unique and multifaceted nutritional challenges arising from genetic, metabolic, and developmental factors. Despite growing interest in the health of individuals with DS, dedicated nutritional guidelines tailored to their specific needs remain lacking. This narrative review aims…

Ulcerative colitis (UC) is a chronic, relapsing, and remitting immune-mediated condition requiring long-term therapy. Moderate to severe disease is managed using steroids, sulfasalazine, thiopurines, biologicals [anti-tumor necrosis factor, anti-integrins, and anti-interleukin (IL) 12/23], and small molecules (janus ki…

BACKGROUND: Acellular dermal matrices (ADMs) have become popularly used in implant-based breast reconstruction (IBBR) due to their potential to decrease the risk of implant complications such as capsular contracture and malposition. AlloDerm and DermACELL are two of the most commonly used human ADMs, each processed dif…

INTRODUCTION: Atrial fibrillation (AF) is the most common cardiac arrhythmia, which significantly contributes to morbidity, mortality, and a diminished quality of life. Despite advancements in pharmacological treatments, many AF patients do not achieve adequate symptom control with oral medications. This network meta-a…

Nutritional status disorders have the most significant impact on the development of cardiovascular and oncologic diseases; therefore, the interest in the study of palm oil as among the leading components of nutrition has been increasing. The data examined in this review were sourced from the Scopus, SCIE (Web of Scienc…

BACKGROUND AND PURPOSE: This systematic review examines the effectiveness of motivational interviewing (MI) on medication adherence for preventing recurrent stroke and transient ischemic attack (TIA). METHODS: MEDLINE (via PubMed), CINAHL, PsycINFO, CENTRAL, and ClinicalTrials.gov were searched from inception to 12 Ju…

BACKGROUND AND AIM: Obesity affects nearly 650 million adults worldwide, and the prevalence is steadily rising. This condition has significant adverse effects on cardiovascular health, increasing the risk of hypertension, coronary artery disease, heart failure, and atrial fibrillation (AF). While anticoagulation f…