1,557,507 papers found

Five of seven acutely manic patients improved significantly when taking verapamil but not placebo in a double-blind crossover study. This finding adds support to two other formal studies of verapamil, several case reports of verapamil in manic patients, and one small study of nifedipine suggesting that some calcium ant…

In a double-blind study, twenty-five subjects who received oral dexamethasone and twenty-five placebo subjects rated their postoperative pain 8 and 24 hours following initial endodontic treatment. The subjects who received dexamethasone reported statistically significantly less postoperative pain than the subjects who…

The Graf classification of sonographic hip-studies is based upon angle-measurements. 167 patients have been examined and evaluated in a double-blind study of the reproducibility of these measurements and the resulting classification. The resulting ranges for the different types were compared with the values given by Gr…

Review of the literature reveals that considerable knowledge has accumulated on intervertebral space infection following lumbar disc surgery. This is based on more than 400 observations. There are, however, no unifying concepts regarding the pathogenesis of the condition. While the reported incidence has seemed to incr…

In a randomized, double-blind cross-over study, 43 patients with classic migraine received 40 mg Nimodipine and placebo as sublingual capsules. There was no significant effect on patients' preference, development of headache, need for escape medicine, duration of headache, severity of headache or headache index. Consid…

Our investigation supports the use of intravenous salbutamol as an alternative to aminophylline in the early stages of acute severe asthma. Salbutamol proved to be a marginally better bronchodilator and is likely to cause less gastrointestinal side effects than aminophylline, but tachycardia and generalized tremor are…

Elderly patients (N = 28) with a variety of psychiatric disorders were treated with molindone in an 8-week open clinical trial. Many patients had concomitant medical illnesses, and many were on other medications in addition to molindone. Molindone appeared to be safe, clinically effective, and well-tolerated. The most…

The practicability and efficiency of a method known as minimization in minimizing the differences between treatment and control groups in clinical trials was investigated in a trial with an anorexiant. Eight factors which might have influenced outcome were identified and used as variates in the minimization programme.…

The authors have utilized the Institut Pasteur anticholeric vaccine by oral passage amid the Malemba - Nkulu area population. The choleric epidemic beginning six months after the vaccine oral passage. The results had been 67 cholera case on 18,377 subjects non inoculated 25 case on 6,249 subjects inoculated by inject v…

This paper outlines the mathematical theory required for eliciting the hyperparameters of a subjective conjugate distribution for the exponential survival model with censoring. The technique involves the quantification of expert knowledge based on determination by the expert of expected fractiles of a survival distribu…

Primary radiation therapy for early breast cancer is a combination of limited breast surgery for the removal of gross disease, and moderate doses of radiation for the control of residual subclinical disease. The results from retrospective studies using primary radiation therapy indicate that high levels of local tumor…

Untreated herpes labialis may take up to 10 days or more to heal and antiviral therapy must be initiated early if it is to be effective. Acyclovir ointment has been reported to have an antiviral effect but no clinical benefit and a newer formulation, acyclovir cream, has been developed in an attempt to enhance skin pen…

A double-blind clinical trial was designed to study the effect of clomipramine in 50 patients complaining of rapid ejaculation. Patients were divided into two groups and each group received 2 periods of 6 consecutive weeks' treatment with drug and placebo, so that comparison can be made between drug and placebo within…

A double-blind clinical trial in 60 patients with perennial rhinitis was conducted to compare the efficacy and side effects of two antihistamines, terfenadine and chlorpheniramine maleate, and placebo. There was no statistically significant difference in response between active treatments and placebo. Although side eff…

A double-blind survey of isaxonine versus a placebo was carried out with two groups of diabetics on clinical and electrophysiological evidence of nervous system impairment. The active agent showed a particularly favourable effect on sensory disorders (paresthesia, pain, perception sensibility). The clinical results wer…

The technique of polarised light goniometry was used to quantify objectively parameters of the spastic gait during a double-blind cross-over trial comparing the spasmolytic effects of DS103-282, baclofen and placebo. Only minimal objective and subjective changes in gait were found when the results of treatment with DS1…

The role the VUR plays in the first development and progressing of the renal parenchymal destruction is generally accepted. The relationship between risk and advantage of a conservative and surgical treatment is still under discussion. A carefully controlled prospective cooperative study aims at a rational base for the…

In a double blind trial, 25 patients with twin pregnancy were given 40 mg of ritodrine hydrochloride by mouth daily and 24 similar patients received a placebo. The ritodrine group had no significant prolongation of pregnancy nor increase in birth weight, and a high incidence of side effects occurred.