1,574,725 papers found

All muscle relaxants can induce allergic or pseudo-allergic reactions. The medium-long-acting, nondepolarizing muscle relaxant atracurium has been shown to be a potent histamine liberator. Up to now it is unknown if a clinical dosage of atracurium exists where no clinically relevant histamine release occurs. In a prosp…

Twenty non-alcoholic patients with DSM-III defined simple phobias for small animals received behavioural approach tests and exposure therapy while under the influence of a moderately intoxicating dose of ethanol or after placebo administration. Ethanol did not demonstrate any acute anti-anxiety effect, but retarded the…

Tetanus toxoid purified by antibody-affinity chromatography, was compared with conventionally purified material in a double-blind trial in 205 healthy blood donors. There was neither any difference in immunogenicity as assessed by enzyme-linked immunoassay nor in side-reactions between the two vaccines. This study conf…

In a prospective 6 weeks study, done in 3 phlebology practices on 107 patients presenting an acute leg ulcer, we compared the efficacy of a combination of compression and HR (O-(Beta-hydroxyethyl)-rutosides with compression alone, based on objective and subjective parameters. These objective and subjective parameters a…

In a double-blind study, twenty-five subjects who received oral dexamethasone and twenty-five placebo subjects rated their postoperative pain 8 and 24 hours following initial endodontic treatment. The subjects who received dexamethasone reported statistically significantly less postoperative pain than the subjects who…

A prospective, double-blind, controlled trial is reported in which oral diclofenac, a prostaglandin inhibitor, was given for 1 week immediately following the removal of splintage for fracture of the distal end of the radius. The patients who received the prostaglandin inhibitor had less pain, a more rapid recovery of r…

The Graf classification of sonographic hip-studies is based upon angle-measurements. 167 patients have been examined and evaluated in a double-blind study of the reproducibility of these measurements and the resulting classification. The resulting ranges for the different types were compared with the values given by Gr…

In a randomized, double-blind cross-over study, 43 patients with classic migraine received 40 mg Nimodipine and placebo as sublingual capsules. There was no significant effect on patients' preference, development of headache, need for escape medicine, duration of headache, severity of headache or headache index. Consid…

Our investigation supports the use of intravenous salbutamol as an alternative to aminophylline in the early stages of acute severe asthma. Salbutamol proved to be a marginally better bronchodilator and is likely to cause less gastrointestinal side effects than aminophylline, but tachycardia and generalized tremor are…

Elderly patients (N = 28) with a variety of psychiatric disorders were treated with molindone in an 8-week open clinical trial. Many patients had concomitant medical illnesses, and many were on other medications in addition to molindone. Molindone appeared to be safe, clinically effective, and well-tolerated. The most…

The practicability and efficiency of a method known as minimization in minimizing the differences between treatment and control groups in clinical trials was investigated in a trial with an anorexiant. Eight factors which might have influenced outcome were identified and used as variates in the minimization programme.…

The authors have utilized the Institut Pasteur anticholeric vaccine by oral passage amid the Malemba - Nkulu area population. The choleric epidemic beginning six months after the vaccine oral passage. The results had been 67 cholera case on 18,377 subjects non inoculated 25 case on 6,249 subjects inoculated by inject v…

Primary radiation therapy for early breast cancer is a combination of limited breast surgery for the removal of gross disease, and moderate doses of radiation for the control of residual subclinical disease. The results from retrospective studies using primary radiation therapy indicate that high levels of local tumor…

Untreated herpes labialis may take up to 10 days or more to heal and antiviral therapy must be initiated early if it is to be effective. Acyclovir ointment has been reported to have an antiviral effect but no clinical benefit and a newer formulation, acyclovir cream, has been developed in an attempt to enhance skin pen…

A double-blind clinical trial was designed to study the effect of clomipramine in 50 patients complaining of rapid ejaculation. Patients were divided into two groups and each group received 2 periods of 6 consecutive weeks' treatment with drug and placebo, so that comparison can be made between drug and placebo within…

A double-blind clinical trial in 60 patients with perennial rhinitis was conducted to compare the efficacy and side effects of two antihistamines, terfenadine and chlorpheniramine maleate, and placebo. There was no statistically significant difference in response between active treatments and placebo. Although side eff…

Post-infusion phlebitis remains one of the most frequent causes of hospital morbidity with an incidence varying between 13 and 39 per cent (1-4). A recent study indicated that a silicone elastomer cannula (Visis) had desirable properties (5). We have carried out a prospective trial comparing the value of such a cannula…