The conclusiveness of trial sequential analysis varies with estimation of between-study variance: a case study.
Kang Enoch, Hodges James S, Chuang Yu-Chieh, +3 more·BMC medical research methodology
BACKGROUND: Trial sequential methods have been introduced to address issues related to increased likelihood of incorrectly rejecting the null hypothesis in meta-analyses due to repeated significance testing. Between-study variance (τ) and its estimate () play a crucial role in both meta-analysis and trial sequent…