Searching PubMed for “Clinical Trial” and checking full-text availability…
for “Clinical Trial” · Showing 9,881–9,900 · 2294 ms
Zador G·Acta obstetricia et gynecologica Scandinavica. Supplement
Abstract not available
Vlasova I N, Fomina I P, Bodunkova L E·Antibiotiki
The results of the study on the pharmacokinetics peculiar properties of carbenicillin premature infants treated with the drug administered intravenously or intramuscularly are presented. The maximum antibiotic blood levels after intravenous administration exceeded the MIC for most of the causative agents isolated from…
Sitaram N, Weingartner H, Gillin J C·Science (New York, N.Y.)
Arecholine (4 milligrams), a cholinergic agonist, and choline (10 grams), a precursor of acetylcholine, significantly enhanced serial learning in normal human subjects. The subjects received methscopolamine prior to both arecholine and placebo injections. Conversely, scopolamine (0.5 milligram), a cholinergic antagonis…
Montagne J P, Moss A A, Margulis A R·AJR. American journal of roentgenology
A total of 100 patients were examined by both single and double contrast upper gastrointestinal radiography. The radiographs were coded, interpreted blindly by two gastrointestinal radiologists, and the accuracy of each examination was determined using endoscopy as the standard. The interpretation error rate for each t…
Muranaka M, Miyamoto T, Shida T, +6 more·Annals of allergy
The efficacy of gold salt on bronchial asthma was investigated by double-blind design in 79 patients. The rate of improvement was significantly higher in the gold-treated group (20/28) than in the controls (16/36). This was reflected by greater reduction of requirement for symptomatic medications. Only mild side effect…
McConnachie R W·Pharmacology
Dementia is a symptom complex probably arising from cerebral metabolic insufficiency. The testing of drugs thought to improve cerebral metabolism is difficult and many problems have to be overcome. Assessment of brain failure requires objective tests of intellect and memory. Subjective tests are used for disorders of p…
Kasanen A, Anttila M, Elfving R, +5 more·Annals of clinical research
Abstract not available
Kaplan B, Cardarelli C, Pinnell S R·Journal of oral pathology
Sixty-five patients with recurrent aphthous stomatitis participated in a double-blind study to evaluate levamisole. Nineteen of 34 patients improved on levamisole and only five of 31 patients improved on placebo (P less than 0.004, chi-square with two degrees of freedom). After breaking the code and switching placebo p…
Anderson G, Wilkins E·Thorax
Clenbuterol is a beta 2-sympathomimetic bronchodilator. In a double-blind cross-over trial in 19 asthmatic patients with reversible airways obstruction, oral administration of both clenbuterol (40 microgram) and salbutamol (4 mg) caused significantly greater increased in peak expiratory flow rate (PEFR) than placebo, t…
Medenica R, Girard J P, Maurice P·Developments in biological standardization
Corynebacterium parvum was administered to sixteen patients with malignant tumors submitted to repeated chemotherapy courses. A total of 428 injections of C. parvum at a dose of 3.5 mg/m2 in weekly, biweekly and monthly administration was given between the chemotherapy courses. Injection of C. parvum was followed by fe…
Larsen H W, Sander E, Hoppe R·Diabetologia
The effect of calcium dobesilate on capillary resistance and background retinopathy was compared with placebo in a double-blind cross-over trial on 18 diabetics. Each treatment lasted 8 months. The trial produced no evidence in favour of a significant beneficial effect of calcium dobesilate on the capillary resistance…
Macfie J, Harvey J·The British journal of surgery
A total of 219 acute superficial abscesses was treated. Patients were randomly allocated to one of four treatment groups--primary suture with or without antibiotics and free drainage with or without antibiotics. No difference could be detected between the groups in duration of healing time. Eleven per cent of all absce…
Barber P V, Chatterjee S S, Scott R·British journal of diseases of the chest
A new anticholinergic aerosol, ipratropium bromide, was compared in a double-blind cross-over trial with an established preparation, deptropine citrate, and placebo in 16 patients with defined asthma or chronic bronchitis. Ipratropium bromide produced a significantly greater and more rapid bronchodilation than did dept…
Hovell B C, Ward A E·The Journal of international medical research
In a comparative trial, buprenorphine 0-3 mg or morphine 10 mg was administered intramuscularly to patients post-operatively. The new drug buprenorphine produced more pain relief than morphine and appeared to have a longer duration of action. The side-effects produced by the two drugs were similar, as were the effect o…
Taeuber K·British journal of clinical pharmacology
1. Methodological reasons are discussed which make placebo-controlled trials on antidepressant drugs necessary. 2. The ethical problem of treating a sick patient with an inactive compound are shown to have an impact on the methodology of such trials. 3. Three double-blind placebo-controlled trials with nomifensine are…
Lehtonen A, Viikari J·Acta medica Scandinavica
In type II A hyperlipoproteinaemia, treatment with cholestyramine (12 g), calcium clofibrate (2 g) and a combination of calcium clofibrate and calcium carbonate (2 + 2 g) reduced the cholesterol concentration. The combination of calcium and clofibrate was at least as effective as cholestyramine. Calcium clofibrate decr…
Magnusson B, Sölvell L, Wessman J·Scandinavian journal of infectious diseases
The gastrointestinal blood loss during intake of two ampicillin esters (pivampicillin and bacampicillin) was studied in 10 male volunteers. A radioactive chromium method was used. The study was performed with a double-blind cross-over technique. Pivampicillin seemed to give a slightly higher increase in gastrointestina…
Dronfield M W, Malone J D, Langman M J·Gut
A double-blind controlled trial of oral zinc sulphate as adjuvant treatment in idiopathic ulcerative colitis or proctitis in relapse is reported. Fifty-one patients were treated, and the clinical and sigmoidoscopic improvement in the zinc treated patients was similar to that in patients receiving placebo. No difference…
Egan E A, Mantilla G, Nelson R M, +1 more·The Journal of pediatrics
Abstract not available
Coppen A, Gupta R, Montgomery S, +1 more·Pharmakopsychiatrie, Neuro-Psychopharmakologie
A double-blind prospective study was carried out comparing the prophylactic effect of maprotiline and lithium carbonate over a period of 1 year in patients suffering from recurrent affective disorders. The average Affective Morbidity Index was lower, but not significantly so, in patients treated with lithium. A further…