44,617 papers found

BACKGROUND: Spasticity is a common post-stroke complication, and it results in substantial deterioration in the quality of life of patients. Although potential positive effects of warm-needle moxibustion on spasticity after stroke have been observed, evidence on its definitive effect remains uncertain. OBJECTIVES: Thi…

BACKGROUND: Glucocorticoids are increasingly used perioperatively, principally to prevent postoperative nausea and vomiting (PONV), and acute postoperative pain following total hip arthroplasty (THA). The authors hypothesized that preoperative intravenous glucocorticoids is associated with less pain scores and PONV wit…

OBJECTIVE:: To review the literature on the effects of expiratory rib cage compression on ventilatory mechanics, airway clearance, and oxygen and hemodynamic indices in mechanically ventilated adults. METHODS:: Systematic review with meta-analysis of randomized clinical trials in the databases MEDLINE (via PubMed), EM…

OBJECTIVES: To determine, using systematic review of the biomedical literature, whether pacing reduces risk of recurrent syncope and relevant clinical outcomes among adult patients with reflex-mediated syncope. METHODS: MEDLINE (through PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials (through O…

BACKGROUND: Heat shock proteins (HSPs) are highly conserved proteins present in all kingdoms of organisms. These are expressed under stress conditions in order to protect the cells from injuries. The stress induced protein denaturation is rectified by refolding and remodelling. These are intracellular proteins but can…

OBJECTIVE: To evaluate the efficacy of noninvasive brain stimulation (NIBS) on pain control in migraine patients. BACKGROUND: Recent studies have used NIBS as an abortive and prophylactic treatment for migraine; however, its efficacy regarding meaningful clinical effects remains to be critically analyzed. DESIGN: Sys…

CONTEXT: The discovery and subsequent ultrastructural characterization of the interstitial Cajal like cells (now called telocytes) in virtually every anatomic sites of the human body, by Laurentiu M Popescu and co-workers, have dramatically improved the understanding the function of these cells and pathogenesis of extr…

INTRODUCTION AND OBJECTIVES: The bibliometric analysis of the Portuguese scientific production in the field of breast pathology since 1995 to date (July 2005) provides an overview on the developed scientific activity on this subject and allows the characterisation of some relevant features as well as its evolution alon…

INTRODUCTION: Extracorporeal cardiopulmonary resuscitation (ECPR) is currently recommended as a rescue therapy for selected patients in refractory out-of-hospital cardiac arrest (OHCA). However, there is conflicting evidence regarding its effect on survival and neurological outcomes. We conducted a systematic review an…

Growth hormone deficiency (GHD) is a prevalent consequence of traumatic brain injury (TBI) that can contribute to prolonged adverse symptoms and impaired quality of life. The overlap between symptoms of GHD and chronic TBI complicates the clinical picture, highlighting the need for precise diagnostic tools. Insulin-lik…

OBJECTIVE: To develop a protocol for a systematic review aimed to evaluate the existing evidence on the use of dalbavancin and oritavancin as suppressive therapy, focusing on their efficacy, effectiveness and safety across different infectious diseases and therapeutic use protocols. METHODS: A systematic review of stu…

BACKGROUND: Secondary lymphedema remains a frequent and debilitating complication of axillary and inguinal lymph node dissection within oncological settings. Prophylactic lymphovenous shunting (LVS) delivered as immediate lymphatic reconstruction (ILR) has emerged as a strategy to preserve lymphatic continuity and redu…

BACKGROUND AND IMPORTANCE: In patients with ST-segment elevation myocardial infarction (STEMI), myocardial loss continues until coronary reperfusion is achieved. OBJECTIVE: To evaluate whether prehospital administration of unfractionated heparin (UFH) improves preprocedural infarct-related artery patency and clinical…

Traditional and ethnomedicine-oriented hospitals operate at the intersection of culturally embedded clinical knowledge, contemporary biomedical evidence, regulatory requirements, and patient expectations. Their quality challenges therefore extend beyond conventional compliance and include the preservation, validation,…

OBJECTIVE: The objective of this study is to provide a practical clinical summary for the effective management of anemia using vitamin B12, folic acid, and especially iron combined with erythropoietin (EPO), to facilitate the implementation of the Patient Blood Management (PBM) program in hospitals. DATA SOURCES: The…

: Registered nurse (RN) prescribing is increasingly discussed as a strategy to improve primary-care access, medication follow-up, chronic disease management, and service responsiveness. The available evidence, however, does not directly test a single coordinated RN prescriber-family physician/nurse practitioner (FP/NP)…

PURPOSE: To understand the use of soft liners/reliners in complete dentures to improve mastication, bite force, and patient's quality of life, and to reduce pain. METHODS: A systematic search was performed in MEDLINE (PubMed), EMBASE, and CENTRAL until May 2025 to find clinical studies comparing removable prostheses w…

BACKGROUND AND AIMS: Standard management of dry eye disease (DED) relies on artificial tears, anti-inflammatory therapy, and punctal occlusion in selected cases. However, some patients continue to report persistent symptoms. The present article reviewed the efficacy of Botulinum Toxin A (BTX-A) for DED that remained sy…

INTRODUCTION: Cancer is the leading cause of death and morbidity among children and adolescents worldwide. Functionality-based interventions are relevant among children and adolescents with an oncological diagnosis, whence studies summarising evidence on this topic are needed. This systematic review will summarise evid…

INTRODUCTION: Hemorrhagic shock caused by trauma is one of the most important contributors to mortality in severely injured patients. Management traditionally includes hemorrhage control and aggressive fluid resuscitation. Severe hemorrhagic shock induces a state of antidiuretic hormone (vasopressin) deficiency, which…