42,199 papers found

BACKGROUND: Primary graft dysfunction (PGD) is the main cause of early morbidity and mortality after lung transplantation. Previous studies have yielded conflicting results for PGD risk factors. Herein, we carried out a systematic review and meta-analysis of published literature to identify recipient-related clinical r…

BACKGROUND: Each year, 287,000 women die from complications related to pregnancy or childbirth, and 3.8 million newborns die before reaching 28 days of life. The near totality (99%) of maternal and neonatal deaths occurs in low- and middle-income countries (LMICs). Utilization of essential obstetric care services inclu…

OBJECTIVES: This evaluation investigates characteristics of health economics evaluations in CAM. Particular emphasis is paid to differences regarding continental origin and time of publication of investigations. METHODS: Database searches to identify potential studies were carried out in Medline (via Pubmed), the Coch…

OBJECTIVES: The advent of biological therapies for inflammatory bowel disease (IBD) began in 1998 with the approval of infliximab for the treatment of refractory (to conventional agents) Crohn's disease (CD). Since then, the indications for anti-tumor necrosis factor-α (anti-TNFα) therapy have increased to…

OBJECTIVE: To summarise the extent to which narrative text fields in administrative health data are used to gather information about the event resulting in presentation to a health care provider for treatment of an injury, and to highlight best practise approaches to conducting narrative text interrogation for injury s…

CONTEXT: Plantar fasciitis (PF) is a common condition in active individuals. The lack of agreement on PF etiology makes treatment challenging and highlights the importance of understanding risk factors for preventive efforts. OBJECTIVE: The purpose of this systematic review and meta-analysis was to determine what fact…

BACKGROUND: Although several studies have examined the relationship between omega-3 (ω-3) fatty acids and pulmonary function and clinical outcomes in critically ill patients, their findings remain mixed and inconclusive, and additional research is warranted. OBJECTIVES: This study aimed to evaluate the effects o…

BACKGROUND: Conventional multi-port laparoscopic cholecystectomy (CMLC) has become the current 'gold standard' technique in gallbladder disease. Single-incision laparoscopic cholecystectomy (SILC) has gained attention due to its benefits in improving patient cosmetic results and pain reduction. We aim to assess the lat…

Aerobic (AT) and resistance training (RT) are well established as effective strategies for lowering blood pressure (BP) in patients with hypertension; however, evidence on the impact of combined training (CT; AT and RT) on BP remains limited. We therefore conducted a meta-analysis of randomized controlled trials (RCTs)…

BACKGROUND: Children with normal Body Mass Index (BMI) may still exhibit adverse metabolic profile-termed as the metabolically obese normal weight (MONW) phenotype, placing them at increased risk of long-term cardiometabolic complications. OBJECTIVE: To systematically synthesise the evidence of the MONW phenotype in c…

BACKGROUND: Clavipectoral fascial plane block (CPB) is a novel regional anesthesia technique for clavicle fracture operation that provides effective analgesia while minimizing phrenic nerve involvement. Traditional approaches, including interscalene brachial plexus block (ISBPB) and superficial cervical plexus block (S…

BACKGROUND: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders (FGIDs) worldwide. Amitriptyline is commonly prescribed for managing the symptoms of IBS as a second-line treatment. This study aimed to consolidate the existing evidence on the pain therapeutic efficacy of amitri…

Nanotechnology-enhanced materials and smart implants are emerging technologies that have shown promise in addressing various challenges in general surgery, including infection management, oncologic staging, and complication monitoring. In this systematic review, we aimed to examine the safety and efficacy of these tech…

Recurrentinfection (RCDI) remains a significant clinical challenge, with high recurrence rates following standard antibiotic therapy. Emerging evidence supports the role of fecal microbiota transplant (FMT) and standardized microbiome therapeutics (e.g., SER-109, RBX2660) in gut microbiota restoration and recurrence pr…

OBJECTIVE: The present meta-analysis compares the effectiveness of cyclophosphamide (CYC) as an immunosuppressant in systemic sclerosis-associated interstitial lung disease (SSc-ILD) with placebo, and other immunosuppressants. METHODOLOGY: The study involved randomized trials and observational studies identified throu…

Evidence on the prevalence of HLA-B*58:01 genotyping and its association with allopurinol-induced severe cutaneous adverse reactions (SCARs) is lacking, especially in low-resource settings. We addressed these gaps by conducting comprehensive and race/ethnic origin-specific evaluations. We conducted a systematic search…

PURPOSE OF REVIEW: Advances in radiation therapy techniques that allow for better normal tissue sparing have made reirradiation (reRT) a more viable option for managing locoregional recurrences in various cancers. However, severe toxicity and a high risk of second recurrence persist, emphasizing the need for improved p…

BACKGROUND: Timing of oral feeding following head and neck mucosal free-flap reconstruction is a highly contentious issue. The typical 6-12 days "nil-by-mouth' primarily revolves around the concern for post-operative complications. Conversely, early feeding has been shown to reduce the patient's stress response, optimi…

OBJECTIVES: Τhe aim of the present systematic review and meta-analysis was to critically appraise all evidence available on the effectiveness of biomimetic hydroxyapatite (HAP) toothpastes in promoting remineralization and inhibiting demineralization. DATA: A literature search was conducted in electronic databas…

: Four randomized controlled trials (RCTs) did not show a benefit of direct oral anticoagulant (DOAC) treatment compared with antiplatelet therapy for the prevention of recurrent strokes in patients with embolic stroke of undetermined source (ESUS). However, the balance between efficacy and safety in subgroups needs to…