43,319 papers found

BACKGROUND: We aimed to evaluate the efficacy and safety of early analgesic interventions, particularly NSAIDs versus opioids, in reducing pain and improving clinical outcomes among adults with AP. METHODS: A systematic literature search was conducted across PubMed, Embase, Cochrane Central Register of Controlled Tria…

The inflammatory skin condition known as diaper dermatitis (DD) often affects infants and preschoolers. Barrier preparations are commonly used in their management, but their effectiveness remains unclear. This systematic review aimed to evaluate the extent to which barrier preparations reduce DD compared to a placebo o…

OBJECTIVES: To systematically review the literature on women's sexual quality of life after transvaginal natural orifice endoscopic surgery (vNOTES) for gynecological and nongynecological procedures, and to assess women's perceptions of vNOTES, the recommended duration of postoperative sexual abstinence (medically advi…

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a primary genetic myocardial disorder associated with sudden cardiac death (SCD) due to ventricular arrhythmias, however risk stratification remains challenging. Electrocardiographic (ECG) markers may offer non-invasive tools for improved risk assessment, but their progn…

Randomized controlled trials (RCTs) are considered the gold standard for evaluating surgical interventions for benign prostatic hyperplasia (BPH). However, the validity and reliability of their findings depend critically on adequate sample size determination and power estimations. Inadequate or absent reporting of thes…

BACKGROUND: Several antiarrhythmic agents, including amiodarone (AMD) and nifekalant (NIF), are used in the management of life-threatening arrhythmias such as ventricular fibrillation (VF) and ventricular tachycardia (VT). Although a few studies have compared the antiarrhythmic effect of NIF and AMD, most have focused…

Caffeine, one of the most widely consumed psychoactive substances, is well known to disturb sleep, yet the extent to which its impact varies by age and dose has not been completely quantified. We searched PubMed, Web of Science, CINAHL, and the Cochrane Library (through March 25, 2025) for controlled crossover trials t…

BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is associated with significant postoperative pain despite being minimally invasive. External oblique intercostal block (EOIB) has emerged as a novel regional anesthesia technique targeting upper abdominal wall innervation. In this systematic review and meta-analysis wit…

Sickle cell retinopathy (SCR) is an ocular manifestation of sickle cell disease (SCD). In SCR abnormal sickling of erythrocytes is associated with sight-threatening complications such as neovascularisation, vitreous haemorrhage, maculopathy and retinal detachment. Optical coherence tomography angiography (OCTA) is a no…

BACKGROUND: To systematically assess the effectiveness and safety of retrograde intrarenal surgery (RIRS) versus percutaneous nephrolithotomy (PCNL) in treating lower pole stones. METHODS: PubMed, Ovid MEDLINE, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), and EMBASE were researched to iden…

Upper blepharoplasty addresses aging-related changes by removing excess skin, muscle, and fat from the upper eyelids. This systematic review, which was registered a priori, improves upon previously published reviews regarding functional and aesthetic outcomes following upper blepharoplasty. Custom search strategies wer…

BACKGROUND: Narcolepsy, a central hypersomnolence disorder, disrupts sleep regulation. Sodium oxybate, a CNS (central nervous system) depressant, is widely used as a treatment, but there are surprisingly very few rigorous studies comparing its effectiveness to placebo in adults. OBJECTIVES: To measure the comparative…

BACKGROUND: In recent years, the association between systemic immune-inflammation index (SII) and the prognosis of patients with colorectal cancer (CRC) has remained a topic of considerable debate. To address this, the present study was carried out to investigate the prognostic significance of SII in CRC. METHODS: Dat…

BACKGROUND: There is ongoing debate about the safety and efficacy of epicutaneous immunotherapy (EPIT) in treating food allergies. The systematic review and meta-analysis aimed to evaluate the safety and efficacy of EPIT. METHODS: We systematically searched international trial registers (ClinicalTrials.gov), PubMed, E…

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory disease that has a typical illness trajectory. Awareness of unique disease courses as well as providing end-of-life care (EOLC) for COPD patients is important as most patients experience varied degrees of suffering toward the end-of-…

INTRODUCTION: There is a high prevalence of attention-deficit/hyperactivity disorder (ADHD) in prison populations compared to the general population, and ADHD has also been shown to be associated with criminality and antisocial behavior. This systematic review examines the effect of pharmacological ADHD treatment on cr…

Dysfunction or damage to the nervous system may develop into and result in a chronic pain condition known as neuropathic pain. Neuropathic pain is defined as the structural and functional alteration of the somatosensory component of the nervous system. The treatment of neuropathic pain is a complex endeavor, which…

OBJECTIVE: To summarize stage migration and survival outcomes in patients with cervical cancer at Stage IIIC according to the 2018 FIGO staging system, and to investigate prognostic factors influencing Stage IIIC1. METHODS: PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), International Clinica…

PURPOSE: To evaluate the effect of oncology services rendered by clinical pharmacists on reducing chemotherapy-induced nausea and vomiting (CINV) and improving overall treatment experiences. METHODS: A systematic review and meta-analysis were conducted using studies retrieved from PubMed, Embase, Cochrane Central Regi…

PURPOSE: The aim of the present study was to report the approach of Greek surgeons regarding patellar management and provide the outcomes and the rate of the need for secondary patella resurfacing. METHODS: Following the PRISMA guidelines, PubMed, Scopus, and The Cochrane Central Register of Controlled Trials (CENTRAL…