44,617 papers found

Total knee arthroplasty (TKA) is frequently performed for advanced knee osteoarthritis. Mechanical alignment (MA) targets restoration of a neutral limb axis, whereas kinematic alignment (KA) aims to reproduce an individual's native pre-arthritic knee alignment. This systematic review evaluates comparative mid-term outc…

: Women are disproportionately affected by depression and generalized anxiety disorder compared to men throughout their lives. Hormonal changes during the menstrual cycle, pregnancy, postpartum, and menopause are often associated with mood disturbances. Evidence suggests that modulating the gut microbiome through gut-t…

OBJECTIVE: To develop and validate a predictive model for the risk of bloodstream infection (BSI) caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). METHODS: A literature search was conducted in PubMed, Cochrane Library, and Embase databases from inception to July 2022 to identify studies reporting statistic…

This systematic review and meta-analysis aimed to evaluate the efficacy and safety of pioglitazone as an add-on therapy to dual treatment with metformin and dapagliflozin in adults with type 2 diabetes mellitus (T2DM) inadequately controlled on this regimen. We conducted a systematic review and meta-analysis of randomi…

BACKGROUND: Cocaine is a widespread drug of abuse to which children can also be exposed. The modes of exposure may vary depending on the age of the child. In addition to blood and urine analysis, hair analysis is currently used in some clinical contexts to investigate children's exposure to drugs of abuse, including co…

BACKGROUND AND AIM: Strong and effective stewardship is a fundamental function of health systems. However, rehabilitation services often receive insufficient attention due to the limited priority assigned to them by governments and health systems. In many countries-particularly low- and middle-income nations-this negle…

Work-related injuries remain a considerable global burden; nevertheless, progress in occupational safety has been made in decreasing the time to return to work. This study aimed to assess the pooled incidence of Return to Work (RTW) among workers with occupational injuries and to identify the key factors influencing RT…

AIM: To assess and evaluate the clinical performance of strip crowns and zirconia crowns as full coverage restorations in children aged 2-6 years, with a focus on gingival health, retention, and recurrent caries. MATERIALS AND METHODS: The current systematic review was drafted by following the recommendations of the P…

BACKGROUND: This study aimed to investigate: (a) the effects of aerobic training (AT) on brachial artery endothelial function, measured by flow-mediated dilatation (FMD) and whether changes inFMD are associated with changes in other cardiovascular health markers in healthy adults; (b) whether intra-individual response…

INTRODUCTION: Adolescent idiopathic scoliosis (AIS) affects an estimated 200 million adolescents globally and curvatures exceeding 30° at skeletal maturity are associated with increased health risks in adulthood. The International Society for the Orthopedic and Rehabilitative Treatment of Scoliosis recommen…

Coronary artery disease (CAD) is a significant health concern that has affected approximately 110 million people worldwide. CAD is defined as persistent narrowing of the coronary arteries as a result of atherosclerotic plaque build-up. Acute coronary syndrome (ACS), which encompasses ST-elevation myocardial infarction…

BACKGROUND: Malaria control depends primarily on rapid and accurate diagnosis followed by successful treatment. Light microscopy is still used as a gold standard method for the diagnosis of malaria. The Sysmex hematology analyzer is a novel method for malaria detection. Therefore, the aim of this review was to investig…

Prior meta-analysis suggested a low incidence of local adverse events after infusion of vasoactive agents via a peripheral venous catheter in children. However, the number of included patients was relatively low, and the vasoactive agents used were mostly dopamine. We performed an updated systematic review with meta-an…

PURPOSE: To ensure the recognition and participation of all potential respondents in health research, surveys and care, including LGBTQIA + broadly, and trans people, specifically, the use of inclusive language should be considered. This scoping review aimed to identify and describe strategies considered…

BACKGROUND: Adolescents with inflammatory bowel disease (IBD) transitioning to adult care is often deemed a challenging period for patients, their carers, and practitioners. The use of structured transition programs is increasingly incorporated into standards of care, yet the optimal format remains unknown. The aim of…

Bioprosthetic mitral valve degeneration is traditionally treated with Redo-SMVR, but the latest ViV-TMVR procedure offers a less invasive and lower risk alternative. A systematic literature search was conducted on Cochrane Central, Scopus, and Medline (PubMed interface) electronic databases from inception till 15th Apr…

Critical illness encompasses the dysfunction of vital organs, the risk of death, and potential reversibility; it is a major cause of morbidity and mortality globally. The pathophysiology underlying many critical illnesses includes bioenergetic failure, inflammation, and oxidative stress. This systematic review aims to…

BACKGROUND: Population-based research on the prevalence and determinants of dementia, Alzheimer's disease, and cognitive impairment is scarce in East Africa. OBJECTIVE: To provide an overview of community- and population-based studies among older adults on the prevalence of dementia and cognitive impairment in East Af…

BACKGROUND: Mental disorders are currently a global public health concern, particularly after the coronavirus disease 2019 (COVID-19) pandemic. Mental health services gradually transitioned to teleservices, employing various methods like texting and videoconferencing. This meta-analysis aimed mainly to quantify the acc…

Few papers focus their attention on VZV vaccination effectiveness among people living with HIV (PLWH). Flanking the live attenuated vaccine (VZL) available, a newly recombinant vaccine (RZV) was recently introduced and approved for HZ prevention among adults. PLWH represents a population on which a particular attention…