11,350,156 papers found

BACKGROUND: A range of sleep disturbances and disorders are problematic in people after stroke; they interfere with recovery of function during poststroke rehabilitation. However, studies to date have focused primarily on the effects of one sleep disorder-obstructive sleep apnea (OSA)-on stroke recovery. OBJECTIVES: T…

BACKGROUND: Attention-Deficit/Hyperactivity Disorder (ADHD) affects approximately 5% of children worldwide and results in significant impairments in daily functioning. Few community-ascertained samples of children with ADHD have been studied prospectively to identify factors associated with differential outcomes. The C…

BACKGROUND: Irresponsible sexual behaviour among school-going adolescents is a major concern among different stakeholders in South Africa. In 2019, among 106 383 registered live births among adolescents in South Africa, 10% were in the Mpumalanga Province. OBJECTIVE: This article explores and reports on the challenges…

Previous studies revealed a link between inflammation and overactivation of the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling in syndromes associated with aging. Pseudoxanthoma elasticum (PXE), a rare autosomal-recessive disorder, arises from mutations in(). On a molecular level,…

PURPOSE: This study's purpose was to explore the experiences of peer supporters regarding their work in a home visit program for people with HIV infection. PATIENTS AND METHODS: A qualitative descriptive study was conducted using focus groups. Participants were 12 HIV-positive peer supporters conducting home visits wi…

Life history theory (LHT) predicts a trade-off between reproductive effort and the pace of biological aging. Energy invested in reproduction is not available for tissue maintenance, thus having more offspring is expected to lead to accelerated senescence. Studies conducted in a variety of non-human species are consiste…

Drawing on the social exchange theory (SET), social cognitive career theory (SCCT) and the conservation of resources (COR) theory, this study aims to investigate the influence of perceived supervisor support on turnover intention among nurses in Bangladesh, examining the mediating role of technological self-efficacy an…

The purpose of this paper is to share lessons learned from a collaborative, community-informed mixed-methods approach to adapting an evidence-based intervention to meet the needs of Latinos with chronic disease and minor depression and their family members. Mixed-methods informed by community-based participatory resear…

OBJECTIVE: Long-chain fatty acids (LCFAs) contribute to metabolic homeostasis in part via gene regulation. This study's objective was to identify novel LCFA target genes in human skeletal muscle cells (myotubes). RESEARCH DESIGN AND METHODS: In vitro methods included culture and treatment of human myotubes and C2C12 c…

BACKGROUND: This study explores the prevalence of subthreshold depression (SubD) and its association with factors in type 2 diabetes mellitus (T2DM) patients. METHODS: This cross-sectional study involved 808 outpatients with T2DM from ten hospitals in Beijing between September 2015 and January 2016. All participants c…

BACKGROUND AND PURPOSE: With improving treatment options, more attention is being paid to the neurocognitive symptoms related to hepatitis C infection (HCI). While HCI-related neurocognitive impairments are frequently subclinical, they can influence patients' quality of life and fitness to work. Objective - The aim of…

This paper investigates the centrality ofin mental health conception and treatment in Malawi.is an African philosophical worldview which stresses that an individual is human as they relate to others, as in the sayingIts communitarian approach contrasts with a predominantly western individualistic worldview;There are sp…

BACKGROUND: In India, the low public health priority given to rare disorders such as hemophilia hinders their management and optimal care, leading to relatively poor health outcomes. This study aims to profile the multidimensional health status of patients with severe hemophilia A, and its association with the use of h…

BACKGROUND: Despite Islam being the world's second largest religion and despite the fact that there are 22 Arabic-speaking nations representing North Africa and the Middle East, little is known about the relationship between spiritual well-being and health-related quality of life (HrQoL) for Arabic-speaking Muslims in…

INTRODUCTION: This study investigates Respectful Maternity Care (RMC) and its determinants in a rural area of Central India. RMC, which is crucial for reducing maternal mortality, emphasizes dignity, privacy, and autonomy during childbirth. The study aligns with the Sustainable Development Goals (SDG) to improve matern…

Before any clinical trial can begin to recruit patients, participating clinical centers must obtain approval from their institutional review board (IRB). When studies are federally funded, such as by the U.S. Department of Health and Human Services (DHHS), centers must also have or obtain a federal compliance agreement…

BACKGROUND: Domestic violence against women (DVAW) is recognised globally as a violation of human rights and a public health concern. This study explores the relationship between DVAW and women's self-rated health status (SRHS). Identifying how DVAW drives women's SRHS could direct targeted interventions required to en…

BACKGROUND: Firearm assaults contribute to nearly 18,000 deaths and at least twice as many injuries annually, with immense human and financial costs. Gun violence survivors especially face unique and long-term physical, mental, economic, and safety-related challenges. Hospital-based violence intervention programs (HVIP…

Levamisole, an anthelmintic drug with cholinergic properties, has been implicated in cases of drug-induced vasculitis when added to cocaine for profit purposes. Neutrophil extracellular trap (NET) formation is a cell death mechanism characterized by extrusion of chromatin decorated with granule proteins. Aberrant NET f…

BACKGROUND: Anaphylaxis has variable clinical presentations and lacks reliable biomarkers. Expression of activation markers on basophils has been useful in assessing sensitization in IgE-mediated diseases but has not been examined in vivo in anaphylaxis. OBJECTIVE: The study's goals were to assess the baseline express…