44,617 papers found

INTRODUCTION: Many scientists have revealed the association between vitamin D deficiency and gestational diabetes mellitus (GDM). The purpose of this review was to evaluate the impact of vitamin D supplementation on maternal and neonatal health measures in GDM. METHODS: A comprehensive systematic literature search in…

OBJECTIVE: Sleep disorders, chronic pain, and fatigue have been long-standing torments in most patients with chronic kidney disease (CKD). In this review, we attempted to explore whether these nontraditional cardiovascular risk factors are associated with increased mortality in patients with CKD. METHOD: Electronic se…

OBJECTIVE: This systematic review to aimed to evaluate the effects of orthopaedic manual therapy (OMT) on pain, improving function, and physical performance in patients with knee osteoarthritis (OA). DATA SOURCES: Four databases (PubMed, Web of Science, CENTRAL, and CINAHL) were searched. STUDY SELECTION: Trials were…

BACKGROUND: Probiotics constitute the viable and beneficial microbes, which offer a dietary means to sustain the balance of gastro-intestinal (GI) microflora. Owing to their multiple health benefits, these have recently gained wide attention among researchers for exploring their potential in safeguarding the health of…

Between western European countries, the hepatitis C virus (HCV) endemic is highest in Italy. The main objective of this paper is to estimate the endemic diffusion of hepatitis C at the national level and by geographical area, with an extrapolation at the regional level and by uniform cohorts of subjects (by sex and yea…

DATA SOURCES: Medline (Pubmed), Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, Google Scholar, Web of Science, Evidence-based Medicine, Scopus, LILACS database, Ovid database, Bibliografia Brasileira de Odontolgogia, Bandolier, Atypon Link, African Journals Online, ProQ…

OBJECTIVE: While genetic risks have been implicated in systemic lupus erythematosus (SLE), the involvement of various genotypes in neuropsychiatric SLE (NPSLE) remains uncertain. The present metaanalysis aimed to combine data from different studies and evaluate the association between each genotype and the risk of deve…

INTRODUCTION: cancer is the second leading cause of death in children between the ages of 0 and 14 years, corresponding to approximately 3% of all cases diagnosed in Brazil. A significant percentage (5-10%) of pediatric cancers are associated with hereditary cancer syndromes, including Li-Fraumeni/Li-Fraumeni-like synd…

We sought to quantify whether health-related quality of life (HRQoL) is improved through exercise training in people with peripheral artery disease (PAD) and to clarify which prescriptions were optimal for improving HRQoL when compared to usual care. We conducted a systematic search (PubMed, CINAHL, Cochrane Central Re…

BACKGROUND: The effects of stress on ill health have become evident in recent years. Under acute stress situations, a cascade of physiological events helps the body mount an appropriate adaptive response. However, under chronic stress situations, this physiological response may lead to wear and tear on the body that ac…

BACKGROUND: Pain remains the cardinal symptom of endometriosis. However, to date, the underlying mechanisms are still only poorly understood. Increasing evidence points towards a close interaction between peripheral nerves, the peritoneal environment and the central nervous system in pain generation and processing. Rec…

BACKGROUND: Physical fitness during childhood and adolescence has been identified as an important determinant of current and future health status. While research has traditionally focused on the association between cardio-respiratory fitness and health outcomes, the association between muscular fitness (MF) and health…

OBJECTIVE: This study aims to compare the efficacy and safety of T-tube free (TTF) versus T-tube drainage (TTD) after laparoscopic common bile duct exploration (LCBDE). BACKGROUND: LCBDE has been proven to be an effective and preferred treatment approach for uncomplicated choledocholithiasis, and the appropriateness o…

BACKGROUND: Ulcerative colitis is a chronic inflammatory bowel disease. Corticosteroids and 5-aminosalicylates are the most commonly used therapies. However, many patients require immunosuppressive therapy when their disease becomes steroid-refractory or dependent. Methotrexate is a medication that is effective for tre…

OBJECTIVE: Duration of status epilepticus (SE) is widely considered a key determinant of outcome severity, but its prognostic value is hard to interpret because definitions of seizure onset, termination, and recurrence, as well as analytical handling, differ substantially across studies. We reviewed its association wit…

PURPOSE: To construct humanistic nursing practice guidelines suitable for stroke patients. DESIGN: This study was a development and validation study of guidelines using multiple methods, including literature review, qualitative research, questionnaire survey, thematic discussion, and Delphi expert consultation. METHO…

TOPIC: Postoperative inflammation after phacoemulsification is routinely managed with topical corticosteroids, while periocular administration may provide a sustained anti-inflammatory effect. CLINICAL RELEVANCE: Pseudophakic cystoid macular edema (PCME) remains a leading cause of suboptimal visual recovery after cata…

BACKGROUND: Cannabis use disorder (CUD) imposes a significant global health burden, yet comparative evidence for the diverse range of non-pharmacological interventions (NPIs) remains fragmented. Existing reviews often combine diverse NPIs into broad categories, overlooking the specific contributions of neurobiological…

A COMMENTARY ON: Alhumoud T, Zankawi A, Li KY, Yu O, Pow E, Lam W. Performance of smartphone cameras for measuring and analyzing dental shade: A systematic review. J Dent. 2026; 166:106506. https://doi.org/10.1016/j.jdent.2026.106506 . DESIGN: A systematic review evaluating the performance of digital single-lens refle…

BACKGROUND: Acute bacterial meningitis (ABM) is a neurological emergency that requires prompt and appropriate antibiotics and corticosteroids. Previously fluid restriction was recommended in the treatment of ABM in view of studies reporting hyponatremia which was due to elevated antidiuretic hormone (ADH) levels. AIMS…