42,199 papers found

INTRODUCTION: Intravenous fluids are essential components of perioperative care, supporting intravascular volume, acid-base balance and electrolyte homeostasis. Despite extensive research in adult surgical populations, paediatric-specific evidence remains limited, and clinical practice frequently relies on extrapolated…

BACKGROUND: Asthma is a heterogeneous inflammatory disease that can cause substantial morbidity, reduced quality of life, and socioeconomic burden when uncontrolled. Biologic therapies have become central to the management of moderate-to-severe asthma by targeting specific inflammatory pathways. METHODS: This overview…

INTRODUCTION: In the field of medicine, there has been a growing understanding of the impact of social and economic inequities on patients' health outcomes. Social medicine was established with the intention of addressing these social and economic drivers of health when caring for patients. Physicians who practise soci…

PURPOSE: To construct humanistic nursing practice guidelines suitable for stroke patients. DESIGN: This study was a development and validation study of guidelines using multiple methods, including literature review, qualitative research, questionnaire survey, thematic discussion, and Delphi expert consultation. METHO…

BACKGROUND: Therapeutic drug monitoring (TDM) may help optimize beta-lactam antibiotic dosing in patients with deep-seated infections. However, its impact on clinical outcomes remains unclear. OBJECTIVE: The objective of this review was to evaluate the existing evidence on the role of TDM and pharmacokinetic/pharmacod…

BACKGROUND: Given the growing global public health burden of Alzheimer's disease, this study used the Bayesian network meta-analysis to assess the effects of pharmacological and non-pharmacological interventions on cognitive function in the population with Alzheimer's disease. METHODS: Two investigators screened the l…

Concurrent chemoradiotherapy (CRT) remains a standard treatment for locally advanced esophageal cancer, yet the approach poses significant cardiotoxic risks due to the proximity of the esophagus to cardiac structures. This systematic review synthesized recent evidence from observational st…

BACKGROUND: Acupoint catgut embedding (ACE) is a therapeutic method for pain management that involves inserting a thread or catgut into the body with anti-hyperalgesic effect. This study aims to systematically review and comprehensively compare the effectiveness of ACE with that of each comparator in the treatment of k…

BACKGROUND: Digital interventions can provide cost-effective, quality health care for patients with chronic conditions. Patients with chronic conditions often are burdened by a substantial load of adhering to a treatment regimen and suffer from impacts on their function and well-being. This treatment burden has consequ…

Erectile dysfunction (ED) is a common and distressing complication following radical prostatectomy, significantly affecting patients' quality of life. Low-intensity extracorporeal shock wave therapy (LI-ESWT) has emerged as a non-invasive modality aimed at enhancing erectile function through tissue regeneration and imp…

Janus kinase inhibitors (JAKi) are emerging agents in the treatment of rheumatological diseases. Their role in rheumatoid arthritis and spondyloarthropathies has been established. The treatment of Takayasu Arteritis (TAK) and Giant Cell Arteritis (GCA) is large vessel vasculitis requiring long courses of glucocorticoid…

OBJECTIVES: This systematic review and meta-analysis investigates the association between statin use and clinical outcomes in non-small cell lung cancer (NSCLC) patients, focusing on the therapeutic potential of statins and their impact on patient prognosis. DESIGN: The review includes a mix of prospective and retrosp…

Vitamin K2 refers to a subfamily of vitamin K isoforms known as Menaquinones and, therefore, indicated as MK-n, the "n" indicating the number of isoprene units present in the side chain. Like the other members of the Vitamin K family, K2 is an enzymatic cofactor for the γ-glutamyl carboxylase (GGCX). This enzyme'…

BACKGROUND: Achalasia is a debilitating esophageal motility disorder characterized by absent peristalsis and incomplete relaxation of the lower esophageal sphincter (LES). Myotomy procedures-primarily peroral endoscopic myotomy (POEM) and laparoscopic Heller myotomy (LHM)-aim to reduce LES pressure and alleviate dyspha…

OBJECTIVE: This systematic review and meta-analysis aimed to investigate the potential association between peri‑implantitis (PI) and peri‑implant oral malignancies (PIOM). DATA AND SOURCES: Systematic searches were conducted in Medline (PubMed), Embase, CENTRAL, and Web of Science up to December 10, 2024…

BACKGROUND: The use of preoperative surgical antibiotic prophylaxis is effective in preventing surgical site infection. However, obesity, a major risk factor for surgical site infection, affects the pharmacokinetics and effectiveness of surgical antibiotic prophylaxis. Evidence for weight-based surgical antibiotic prop…

OBJECTIVE: The goal of this systematic review was to verify whether the gingival phenotype (thick or thin) could impact the dental implant survival rate by affecting the marginal bone. METHODS: The search was carried out on PubMed/MedLine, PubMed Central, and B-On databases. The research question was: "Does gingival p…

BACKGROUND: Adults with congenital heart disease (ACHD) can face a lifelong risk of premature cardiovascular events. Endothelial dysfunction and arterial stiffness may be some of the key mechanisms involved. Early identification of endothelial damage in ACHD could be crucial to mitigate the adverse events. This systema…

PURPOSE: While strengthening exercises are recommended for knee osteoarthritis (KOA) treatment, the optimal type of muscle contraction remains unclear, with current research showing conflicting results. This network meta-analysis (NMA) aims to evaluate the efficacy of lower limb strengthening exercises based on differe…

BACKGROUND: Psoriasis, a chronic autoimmune condition, imposes significant burdens on patients' well-being. While corticosteroid medications are commonly used, their prolonged use presents risks. Statins, known for their immunoregulatory and anti-inflammatory properties, have emerged as potential alternatives. Previous…